| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DNMT1 | DNMT3B | ENSPPYP00000010706 | ENSPPYP00000012188 | DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | DNMT3B isoform 3; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | 0.999 |
| DNMT1 | H3-4 | ENSPPYP00000010706 | ENSPPYP00000000136 | DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | Histone H3; Belongs to the histone H3 family. | 0.852 |
| DNMT1 | HDAC1 | ENSPPYP00000010706 | ENSPPYP00000001838 | DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium st [...] | 0.988 |
| DNMT1 | KAT5 | ENSPPYP00000010706 | ENSPPYP00000003532 | DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | Histone acetyltransferase KAT5; Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replica [...] | 0.665 |
| DNMT1 | LIG1 | ENSPPYP00000010706 | ENSPPYP00000011392 | DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | DNA ligase. | 0.636 |
| DNMT1 | UHRF1 | ENSPPYP00000010706 | ENSPPYP00000010564 | DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | UHRF1 isoform 6. | 0.997 |
| DNMT1 | USP7 | ENSPPYP00000010706 | ENSPPYP00000008014 | DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | USP7 isoform 8; Belongs to the peptidase C19 family. | 0.935 |
| DNMT3B | DNMT1 | ENSPPYP00000012188 | ENSPPYP00000010706 | DNMT3B isoform 3; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | 0.999 |
| DNMT3B | H3-4 | ENSPPYP00000012188 | ENSPPYP00000000136 | DNMT3B isoform 3; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | Histone H3; Belongs to the histone H3 family. | 0.888 |
| DNMT3B | HDAC1 | ENSPPYP00000012188 | ENSPPYP00000001838 | DNMT3B isoform 3; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium st [...] | 0.940 |
| DNMT3B | UHRF1 | ENSPPYP00000012188 | ENSPPYP00000010564 | DNMT3B isoform 3; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | UHRF1 isoform 6. | 0.888 |
| DPPA3 | UHRF1 | ENSPPYP00000004823 | ENSPPYP00000010564 | Developmental pluripotency associated 3. | UHRF1 isoform 6. | 0.964 |
| H3-4 | DNMT1 | ENSPPYP00000000136 | ENSPPYP00000010706 | Histone H3; Belongs to the histone H3 family. | DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | 0.852 |
| H3-4 | DNMT3B | ENSPPYP00000000136 | ENSPPYP00000012188 | Histone H3; Belongs to the histone H3 family. | DNMT3B isoform 3; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | 0.888 |
| H3-4 | HDAC1 | ENSPPYP00000000136 | ENSPPYP00000001838 | Histone H3; Belongs to the histone H3 family. | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium st [...] | 0.788 |
| H3-4 | KAT5 | ENSPPYP00000000136 | ENSPPYP00000003532 | Histone H3; Belongs to the histone H3 family. | Histone acetyltransferase KAT5; Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replica [...] | 0.595 |
| H3-4 | KIF2C | ENSPPYP00000000136 | ENSPPYP00000001652 | Histone H3; Belongs to the histone H3 family. | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | 0.518 |
| H3-4 | UHRF1 | ENSPPYP00000000136 | ENSPPYP00000010564 | Histone H3; Belongs to the histone H3 family. | UHRF1 isoform 6. | 0.946 |
| HDAC1 | DNMT1 | ENSPPYP00000001838 | ENSPPYP00000010706 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium st [...] | DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | 0.988 |
| HDAC1 | DNMT3B | ENSPPYP00000001838 | ENSPPYP00000012188 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium st [...] | DNMT3B isoform 3; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | 0.940 |
