STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MAP2K7Mitogen-activated protein kinase kinase 7. (435 aa)    
Predicted Functional Partners:
MAPK8
Mitogen-activated protein kinase.
   
0.995
MAPK8IP1
MAPK8IP1 isoform 1.
    
 0.988
MAP3K1
MAP3K1 isoform 1.
    
0.984
MAPK10
Mitogen-activated protein kinase.
   
0.980
MAPK9
Mitogen-activated protein kinase.
   
0.980
MAPK8IP2
MAPK8IP2 isoform 2.
    
 0.979
MAP3K7
Mitogen-activated protein kinase kinase kinase 7; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as a [...]
   
0.979
MAP2K4
Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily.
  
 
0.971
MAP3K20
MAP3K20 isoform 1.
   
0.967
MAP3K11
Mitogen-activated protein kinase kinase kinase.
   
0.966
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.