KEAP1 protein (Pongo abelii) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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proteins of unknown 3D structure

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Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CUL3	DPP3	ENSPPYP00000014786	ENSPPYP00000003499	CUL3 isoform 1; Belongs to the cullin family.	Dipeptidyl-peptidase III.	0.401
CUL3	IKBKB	ENSPPYP00000014786	ENSPPYP00000020804	CUL3 isoform 1; Belongs to the cullin family.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.469
CUL3	KEAP1	ENSPPYP00000014786	ENSPPYP00000010716	CUL3 isoform 1; Belongs to the cullin family.	Kelch-like ECH-associated protein 1; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting NFE2L2/NRF2 for ubiquitination. KEAP1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of NFE2L2/NRF2, a transcription factor regulating expression of many cytoprotective genes. In response to oxidative stress, different electrophile metabolites trigger non-enzymatic covalent modifications of highly reactive cysteine [...]	0.994
CUL3	KLHL9	ENSPPYP00000014786	ENSPPYP00000021487	CUL3 isoform 1; Belongs to the cullin family.	Kelch like family member 9.	0.981
CUL3	NFE2L1	ENSPPYP00000014786	ENSPPYP00000009969	CUL3 isoform 1; Belongs to the cullin family.	Endoplasmic reticulum membrane sensor NFE2L1; [Endoplasmic reticulum membrane sensor NFE2L1]: Endoplasmic reticulum membrane sensor that translocates into the nucleus in response to various stresses to act as a transcription factor (By similarity). Constitutes a precursor of the transcription factor NRF1 (By similarity). Able to detect various cellular stresses, such as cholesterol excess, oxidative stress or proteasome inhibition (By similarity). In response to stress, it is released from the endoplasmic reticulum membrane following cleavage by the protease DDI2 and translocates into [...]	0.696
CUL3	NFE2L2	ENSPPYP00000014786	ENSPPYP00000014484	CUL3 isoform 1; Belongs to the cullin family.	NFE2L2 isoform 2.	0.932
CUL3	PALB2	ENSPPYP00000014786	ENSPPYP00000008134	CUL3 isoform 1; Belongs to the cullin family.	Partner and localizer of BRCA2.	0.438
CUL3	RBX1	ENSPPYP00000014786	ENSPPYP00000013235	CUL3 isoform 1; Belongs to the cullin family.	RBX1 isoform 1.	0.998
CUL3	SQSTM1	ENSPPYP00000014786	ENSPPYP00000018045	CUL3 isoform 1; Belongs to the cullin family.	Sequestosome-1; Autophagy receptor required for selective macroautophagy (aggrephagy). Functions as a bridge between polyubiquitinated cargo and autophagosomes. Interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. Required both for the formation and autophagic degradation of polyubiquitin- containing bodies, called ALIS (aggresome-like induced structures) and links ALIS to the autophagic machinery. Involved in midbody ring degradation (By similarity). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and [...]	0.949
DPP3	CUL3	ENSPPYP00000003499	ENSPPYP00000014786	Dipeptidyl-peptidase III.	CUL3 isoform 1; Belongs to the cullin family.	0.401
DPP3	KEAP1	ENSPPYP00000003499	ENSPPYP00000010716	Dipeptidyl-peptidase III.	Kelch-like ECH-associated protein 1; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting NFE2L2/NRF2 for ubiquitination. KEAP1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of NFE2L2/NRF2, a transcription factor regulating expression of many cytoprotective genes. In response to oxidative stress, different electrophile metabolites trigger non-enzymatic covalent modifications of highly reactive cysteine [...]	0.944
DPP3	PALB2	ENSPPYP00000003499	ENSPPYP00000008134	Dipeptidyl-peptidase III.	Partner and localizer of BRCA2.	0.656
IKBKB	CUL3	ENSPPYP00000020804	ENSPPYP00000014786	Inhibitor of nuclear factor kappa B kinase subunit beta.	CUL3 isoform 1; Belongs to the cullin family.	0.469
IKBKB	KEAP1	ENSPPYP00000020804	ENSPPYP00000010716	Inhibitor of nuclear factor kappa B kinase subunit beta.	Kelch-like ECH-associated protein 1; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting NFE2L2/NRF2 for ubiquitination. KEAP1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of NFE2L2/NRF2, a transcription factor regulating expression of many cytoprotective genes. In response to oxidative stress, different electrophile metabolites trigger non-enzymatic covalent modifications of highly reactive cysteine [...]	0.943
IKBKB	SQSTM1	ENSPPYP00000020804	ENSPPYP00000018045	Inhibitor of nuclear factor kappa B kinase subunit beta.	Sequestosome-1; Autophagy receptor required for selective macroautophagy (aggrephagy). Functions as a bridge between polyubiquitinated cargo and autophagosomes. Interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. Required both for the formation and autophagic degradation of polyubiquitin- containing bodies, called ALIS (aggresome-like induced structures) and links ALIS to the autophagic machinery. Involved in midbody ring degradation (By similarity). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and [...]	0.808
KEAP1	CUL3	ENSPPYP00000010716	ENSPPYP00000014786	Kelch-like ECH-associated protein 1; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting NFE2L2/NRF2 for ubiquitination. KEAP1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of NFE2L2/NRF2, a transcription factor regulating expression of many cytoprotective genes. In response to oxidative stress, different electrophile metabolites trigger non-enzymatic covalent modifications of highly reactive cysteine [...]	CUL3 isoform 1; Belongs to the cullin family.	0.994
KEAP1	DPP3	ENSPPYP00000010716	ENSPPYP00000003499	Kelch-like ECH-associated protein 1; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting NFE2L2/NRF2 for ubiquitination. KEAP1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of NFE2L2/NRF2, a transcription factor regulating expression of many cytoprotective genes. In response to oxidative stress, different electrophile metabolites trigger non-enzymatic covalent modifications of highly reactive cysteine [...]	Dipeptidyl-peptidase III.	0.944
KEAP1	IKBKB	ENSPPYP00000010716	ENSPPYP00000020804	Kelch-like ECH-associated protein 1; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting NFE2L2/NRF2 for ubiquitination. KEAP1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of NFE2L2/NRF2, a transcription factor regulating expression of many cytoprotective genes. In response to oxidative stress, different electrophile metabolites trigger non-enzymatic covalent modifications of highly reactive cysteine [...]	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.943
KEAP1	KLHL9	ENSPPYP00000010716	ENSPPYP00000021487	Kelch-like ECH-associated protein 1; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting NFE2L2/NRF2 for ubiquitination. KEAP1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of NFE2L2/NRF2, a transcription factor regulating expression of many cytoprotective genes. In response to oxidative stress, different electrophile metabolites trigger non-enzymatic covalent modifications of highly reactive cysteine [...]	Kelch like family member 9.	0.932
KEAP1	MCM3	ENSPPYP00000010716	ENSPPYP00000018688	Kelch-like ECH-associated protein 1; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting NFE2L2/NRF2 for ubiquitination. KEAP1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of NFE2L2/NRF2, a transcription factor regulating expression of many cytoprotective genes. In response to oxidative stress, different electrophile metabolites trigger non-enzymatic covalent modifications of highly reactive cysteine [...]	DNA replication licensing factor MCM3; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.919