| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BRD2 | BRD3 | ENSPPYP00000019309 | ENSPPYP00000022145 | BRD2 isoform 1. | Bromodomain containing 3. | 0.989 |
| BRD2 | BRD4 | ENSPPYP00000019309 | ENSPPYP00000010837 | BRD2 isoform 1. | Bromodomain containing 4. | 0.970 |
| BRD2 | CCNT1 | ENSPPYP00000019309 | ENSPPYP00000005098 | BRD2 isoform 1. | CCNT1 isoform 2; Belongs to the cyclin family. | 0.627 |
| BRD2 | CHD4 | ENSPPYP00000019309 | ENSPPYP00000004777 | BRD2 isoform 1. | CHD4 isoform 1. | 0.706 |
| BRD2 | CR201_G0027625 | ENSPPYP00000019309 | ENSPPYP00000021999 | BRD2 isoform 1. | CDK9 isoform 1; Belongs to the protein kinase superfamily. | 0.666 |
| BRD2 | JMJD6 | ENSPPYP00000019309 | ENSPPYP00000009734 | BRD2 isoform 1. | Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6; Dioxygenase that can both act as a arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5- hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Regulates RNA splicing by mediating 5- hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. Hydroxylates its own N-terminus, which is required for homooligomerization. In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by it [...] | 0.597 |
| BRD2 | MED1 | ENSPPYP00000019309 | ENSPPYP00000009539 | BRD2 isoform 1. | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Acts as a coactivator for [...] | 0.495 |
| BRD2 | NSD2 | ENSPPYP00000019309 | ENSPPYP00000016243 | BRD2 isoform 1. | NSD2 isoform 1. | 0.734 |
| BRD2 | NSD3 | ENSPPYP00000019309 | ENSPPYP00000020764 | BRD2 isoform 1. | NSD3 isoform 1. | 0.805 |
| BRD2 | SPOP | ENSPPYP00000019309 | ENSPPYP00000010012 | BRD2 isoform 1. | Speckle-type POZ protein; Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. In complex with CUL3, involved in ubiquitination and proteasomal degradation of BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. In complex with CUL3, involved in ubiquitination of MACROH2A1 and BMI1; this does not lead to their proteasomal degradation. Inhibits transcriptional activation of PDX1/IPF1 targets, such as insulin, by promoting PDX1/IPF1 degradation. The cullin-RING- [...] | 0.818 |
| BRD3 | BRD2 | ENSPPYP00000022145 | ENSPPYP00000019309 | Bromodomain containing 3. | BRD2 isoform 1. | 0.989 |
| BRD3 | BRD4 | ENSPPYP00000022145 | ENSPPYP00000010837 | Bromodomain containing 3. | Bromodomain containing 4. | 0.989 |
| BRD3 | CCNT1 | ENSPPYP00000022145 | ENSPPYP00000005098 | Bromodomain containing 3. | CCNT1 isoform 2; Belongs to the cyclin family. | 0.612 |
| BRD3 | CHD4 | ENSPPYP00000022145 | ENSPPYP00000004777 | Bromodomain containing 3. | CHD4 isoform 1. | 0.811 |
| BRD3 | CR201_G0027625 | ENSPPYP00000022145 | ENSPPYP00000021999 | Bromodomain containing 3. | CDK9 isoform 1; Belongs to the protein kinase superfamily. | 0.639 |
| BRD3 | JMJD6 | ENSPPYP00000022145 | ENSPPYP00000009734 | Bromodomain containing 3. | Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6; Dioxygenase that can both act as a arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5- hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Regulates RNA splicing by mediating 5- hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. Hydroxylates its own N-terminus, which is required for homooligomerization. In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by it [...] | 0.598 |
| BRD3 | MED1 | ENSPPYP00000022145 | ENSPPYP00000009539 | Bromodomain containing 3. | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Acts as a coactivator for [...] | 0.495 |
| BRD3 | NSD2 | ENSPPYP00000022145 | ENSPPYP00000016243 | Bromodomain containing 3. | NSD2 isoform 1. | 0.737 |
| BRD3 | NSD3 | ENSPPYP00000022145 | ENSPPYP00000020764 | Bromodomain containing 3. | NSD3 isoform 1. | 0.845 |
| BRD3 | SPOP | ENSPPYP00000022145 | ENSPPYP00000010012 | Bromodomain containing 3. | Speckle-type POZ protein; Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. In complex with CUL3, involved in ubiquitination and proteasomal degradation of BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. In complex with CUL3, involved in ubiquitination of MACROH2A1 and BMI1; this does not lead to their proteasomal degradation. Inhibits transcriptional activation of PDX1/IPF1 targets, such as insulin, by promoting PDX1/IPF1 degradation. The cullin-RING- [...] | 0.835 |
