Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of proteins in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| HSP90AB1 | RPTOR | ENSPPYP00000018631 | ENSPPYP00000024617 | Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...] | RPTOR isoform 4. | 0.613 |
| HSP90AB1 | STK11 | ENSPPYP00000018631 | ENSPPYP00000010446 | Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...] | Serine/threonine kinase 11; Belongs to the protein kinase superfamily. | 0.594 |
| HSP90AB1 | TSSK6 | ENSPPYP00000018631 | ENSPPYP00000010944 | Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...] | Testis specific serine kinase 6; Belongs to the protein kinase superfamily. | 0.721 |
| PRKAB1 | PRKAB2 | ENSPPYP00000005719 | ENSPPYP00000001096 | 5'-AMP-activated protein kinase subunit beta-1; Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a reg [...] | Protein kinase AMP-activated non-catalytic subunit beta 2. | 0.996 |
| PRKAB1 | PRKAG1 | ENSPPYP00000005719 | ENSPPYP00000005111 | 5'-AMP-activated protein kinase subunit beta-1; Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a reg [...] | Protein kinase AMP-activated non-catalytic subunit gamma 1. | 0.999 |
| PRKAB1 | PRKAG2 | ENSPPYP00000005719 | ENSPPYP00000020405 | 5'-AMP-activated protein kinase subunit beta-1; Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a reg [...] | 5'-AMP-activated protein kinase subunit gamma-2; AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a [...] | 0.975 |
| PRKAB1 | PRKAG3 | ENSPPYP00000005719 | ENSPPYP00000014733 | 5'-AMP-activated protein kinase subunit beta-1; Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a reg [...] | PRKAG3 isoform 1. | 0.997 |
| PRKAB1 | RPTOR | ENSPPYP00000005719 | ENSPPYP00000024617 | 5'-AMP-activated protein kinase subunit beta-1; Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a reg [...] | RPTOR isoform 4. | 0.963 |
| PRKAB1 | STK11 | ENSPPYP00000005719 | ENSPPYP00000010446 | 5'-AMP-activated protein kinase subunit beta-1; Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a reg [...] | Serine/threonine kinase 11; Belongs to the protein kinase superfamily. | 0.977 |
| PRKAB1 | TSSK6 | ENSPPYP00000005719 | ENSPPYP00000010944 | 5'-AMP-activated protein kinase subunit beta-1; Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a reg [...] | Testis specific serine kinase 6; Belongs to the protein kinase superfamily. | 0.641 |
| PRKAB2 | PRKAB1 | ENSPPYP00000001096 | ENSPPYP00000005719 | Protein kinase AMP-activated non-catalytic subunit beta 2. | 5'-AMP-activated protein kinase subunit beta-1; Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a reg [...] | 0.996 |
| PRKAB2 | PRKAG1 | ENSPPYP00000001096 | ENSPPYP00000005111 | Protein kinase AMP-activated non-catalytic subunit beta 2. | Protein kinase AMP-activated non-catalytic subunit gamma 1. | 0.999 |
| PRKAB2 | PRKAG2 | ENSPPYP00000001096 | ENSPPYP00000020405 | Protein kinase AMP-activated non-catalytic subunit beta 2. | 5'-AMP-activated protein kinase subunit gamma-2; AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a [...] | 0.975 |
| PRKAB2 | PRKAG3 | ENSPPYP00000001096 | ENSPPYP00000014733 | Protein kinase AMP-activated non-catalytic subunit beta 2. | PRKAG3 isoform 1. | 0.997 |
| PRKAB2 | RPTOR | ENSPPYP00000001096 | ENSPPYP00000024617 | Protein kinase AMP-activated non-catalytic subunit beta 2. | RPTOR isoform 4. | 0.957 |
| PRKAB2 | STK11 | ENSPPYP00000001096 | ENSPPYP00000010446 | Protein kinase AMP-activated non-catalytic subunit beta 2. | Serine/threonine kinase 11; Belongs to the protein kinase superfamily. | 0.975 |
| PRKAB2 | TSSK6 | ENSPPYP00000001096 | ENSPPYP00000010944 | Protein kinase AMP-activated non-catalytic subunit beta 2. | Testis specific serine kinase 6; Belongs to the protein kinase superfamily. | 0.641 |
| PRKAG1 | PRKAB1 | ENSPPYP00000005111 | ENSPPYP00000005719 | Protein kinase AMP-activated non-catalytic subunit gamma 1. | 5'-AMP-activated protein kinase subunit beta-1; Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a reg [...] | 0.999 |
| PRKAG1 | PRKAB2 | ENSPPYP00000005111 | ENSPPYP00000001096 | Protein kinase AMP-activated non-catalytic subunit gamma 1. | Protein kinase AMP-activated non-catalytic subunit beta 2. | 0.999 |
| PRKAG1 | PRKAG2 | ENSPPYP00000005111 | ENSPPYP00000020405 | Protein kinase AMP-activated non-catalytic subunit gamma 1. | 5'-AMP-activated protein kinase subunit gamma-2; AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a [...] | 0.901 |
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