| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ASPM | CENPJ | ENSPPYP00000000440 | ENSPPYP00000005941 | ASPM isoform 2. | CENPJ isoform 2. | 0.825 |
| ASPM | CEP63 | ENSPPYP00000000440 | ENSPPYP00000015800 | ASPM isoform 2. | Centrosomal protein of 63 kDa; Required for normal spindle assembly. Plays a key role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication. Also recruits CDK1 to centrosomes (By similarity). Plays a role in DNA damage response. Following DNA damage, such as double- strand breaks (DSBs), is removed from centrosomes; this leads to the inactivation of spindle assembly and delay in mitotic progression (By similarity). | 0.664 |
| ASPM | MCPH1 | ENSPPYP00000000440 | ENSPPYP00000020513 | ASPM isoform 2. | MCPH1 isoform 1. | 0.897 |
| ASPM | STIL | ENSPPYP00000000440 | ENSPPYP00000001600 | ASPM isoform 2. | STIL isoform 3. | 0.819 |
| ASPM | WDR62 | ENSPPYP00000000440 | ENSPPYP00000011077 | ASPM isoform 2. | WDR62 isoform 5. | 0.803 |
| CENPJ | ASPM | ENSPPYP00000005941 | ENSPPYP00000000440 | CENPJ isoform 2. | ASPM isoform 2. | 0.825 |
| CENPJ | CEP63 | ENSPPYP00000005941 | ENSPPYP00000015800 | CENPJ isoform 2. | Centrosomal protein of 63 kDa; Required for normal spindle assembly. Plays a key role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication. Also recruits CDK1 to centrosomes (By similarity). Plays a role in DNA damage response. Following DNA damage, such as double- strand breaks (DSBs), is removed from centrosomes; this leads to the inactivation of spindle assembly and delay in mitotic progression (By similarity). | 0.706 |
| CENPJ | MCPH1 | ENSPPYP00000005941 | ENSPPYP00000020513 | CENPJ isoform 2. | MCPH1 isoform 1. | 0.780 |
| CENPJ | STIL | ENSPPYP00000005941 | ENSPPYP00000001600 | CENPJ isoform 2. | STIL isoform 3. | 0.966 |
| CENPJ | WDR62 | ENSPPYP00000005941 | ENSPPYP00000011077 | CENPJ isoform 2. | WDR62 isoform 5. | 0.803 |
| CEP170 | CEP63 | ENSPPYP00000000060 | ENSPPYP00000015800 | CEP170 isoform 3. | Centrosomal protein of 63 kDa; Required for normal spindle assembly. Plays a key role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication. Also recruits CDK1 to centrosomes (By similarity). Plays a role in DNA damage response. Following DNA damage, such as double- strand breaks (DSBs), is removed from centrosomes; this leads to the inactivation of spindle assembly and delay in mitotic progression (By similarity). | 0.529 |
| CEP170 | WDR62 | ENSPPYP00000000060 | ENSPPYP00000011077 | CEP170 isoform 3. | WDR62 isoform 5. | 0.903 |
| CEP170 | YWHAQ | ENSPPYP00000000060 | ENSPPYP00000014137 | CEP170 isoform 3. | 14-3-3 protein theta; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1 (By similarity). | 0.610 |
| CEP63 | ASPM | ENSPPYP00000015800 | ENSPPYP00000000440 | Centrosomal protein of 63 kDa; Required for normal spindle assembly. Plays a key role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication. Also recruits CDK1 to centrosomes (By similarity). Plays a role in DNA damage response. Following DNA damage, such as double- strand breaks (DSBs), is removed from centrosomes; this leads to the inactivation of spindle assembly and delay in mitotic progression (By similarity). | ASPM isoform 2. | 0.664 |
| CEP63 | CENPJ | ENSPPYP00000015800 | ENSPPYP00000005941 | Centrosomal protein of 63 kDa; Required for normal spindle assembly. Plays a key role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication. Also recruits CDK1 to centrosomes (By similarity). Plays a role in DNA damage response. Following DNA damage, such as double- strand breaks (DSBs), is removed from centrosomes; this leads to the inactivation of spindle assembly and delay in mitotic progression (By similarity). | CENPJ isoform 2. | 0.706 |
| CEP63 | CEP170 | ENSPPYP00000015800 | ENSPPYP00000000060 | Centrosomal protein of 63 kDa; Required for normal spindle assembly. Plays a key role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication. Also recruits CDK1 to centrosomes (By similarity). Plays a role in DNA damage response. Following DNA damage, such as double- strand breaks (DSBs), is removed from centrosomes; this leads to the inactivation of spindle assembly and delay in mitotic progression (By similarity). | CEP170 isoform 3. | 0.529 |
| CEP63 | STIL | ENSPPYP00000015800 | ENSPPYP00000001600 | Centrosomal protein of 63 kDa; Required for normal spindle assembly. Plays a key role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication. Also recruits CDK1 to centrosomes (By similarity). Plays a role in DNA damage response. Following DNA damage, such as double- strand breaks (DSBs), is removed from centrosomes; this leads to the inactivation of spindle assembly and delay in mitotic progression (By similarity). | STIL isoform 3. | 0.730 |
| CEP63 | WDR62 | ENSPPYP00000015800 | ENSPPYP00000011077 | Centrosomal protein of 63 kDa; Required for normal spindle assembly. Plays a key role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication. Also recruits CDK1 to centrosomes (By similarity). Plays a role in DNA damage response. Following DNA damage, such as double- strand breaks (DSBs), is removed from centrosomes; this leads to the inactivation of spindle assembly and delay in mitotic progression (By similarity). | WDR62 isoform 5. | 0.755 |
| MAPK10 | MAPK8 | ENSPPYP00000016644 | ENSPPYP00000002621 | Mitogen-activated protein kinase. | Mitogen-activated protein kinase. | 0.901 |
| MAPK10 | MAPK9 | ENSPPYP00000016644 | ENSPPYP00000018050 | Mitogen-activated protein kinase. | Mitogen-activated protein kinase. | 0.997 |
