| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACTB | ACTG1 | ENSPPYP00000019427 | ENSPPYP00000009805 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | ACTG1 isoform 10. | 0.999 |
| ACTB | ACTN1 | ENSPPYP00000019427 | ENSPPYP00000006748 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | ACTN1 isoform 1. | 0.939 |
| ACTB | ACTN2 | ENSPPYP00000019427 | ENSPPYP00000000084 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | ACTN2 isoform 1. | 0.820 |
| ACTB | ACTN3 | ENSPPYP00000019427 | ENSPPYP00000024010 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Actinin alpha 2/3. | 0.447 |
| ACTB | ACTN4 | ENSPPYP00000019427 | ENSPPYP00000011127 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Alpha-actinin-4; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions. May also function as a transcriptional coactivator, stimulating transcri [...] | 0.968 |
| ACTB | CTNNA1 | ENSPPYP00000019427 | ENSPPYP00000017700 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | CTNNA1 isoform 1. | 0.927 |
| ACTB | CTNNA2 | ENSPPYP00000019427 | ENSPPYP00000013655 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Catenin alpha-2; May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system. Required for proper regulation of cortical neuronal migration and neurite growth. It acts as negative regulator of Arp2/3 complex activity and Arp2/3-mediated actin polymerization. It thereby suppresses excessive actin branching which would impair neurite growth and stability. Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of star [...] | 0.927 |
| ACTB | VCL | ENSPPYP00000019427 | ENSPPYP00000002699 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | VCL isoform 2. | 0.962 |
| ACTB | ZYX | ENSPPYP00000019427 | ENSPPYP00000020326 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | ZYX isoform 1. | 0.913 |
| ACTG1 | ACTB | ENSPPYP00000009805 | ENSPPYP00000019427 | ACTG1 isoform 10. | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | 0.999 |
| ACTG1 | ACTN1 | ENSPPYP00000009805 | ENSPPYP00000006748 | ACTG1 isoform 10. | ACTN1 isoform 1. | 0.944 |
| ACTG1 | ACTN2 | ENSPPYP00000009805 | ENSPPYP00000000084 | ACTG1 isoform 10. | ACTN2 isoform 1. | 0.528 |
| ACTG1 | ACTN3 | ENSPPYP00000009805 | ENSPPYP00000024010 | ACTG1 isoform 10. | Actinin alpha 2/3. | 0.447 |
| ACTG1 | ACTN4 | ENSPPYP00000009805 | ENSPPYP00000011127 | ACTG1 isoform 10. | Alpha-actinin-4; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions. May also function as a transcriptional coactivator, stimulating transcri [...] | 0.948 |
| ACTG1 | CTNNA1 | ENSPPYP00000009805 | ENSPPYP00000017700 | ACTG1 isoform 10. | CTNNA1 isoform 1. | 0.927 |
| ACTG1 | CTNNA2 | ENSPPYP00000009805 | ENSPPYP00000013655 | ACTG1 isoform 10. | Catenin alpha-2; May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system. Required for proper regulation of cortical neuronal migration and neurite growth. It acts as negative regulator of Arp2/3 complex activity and Arp2/3-mediated actin polymerization. It thereby suppresses excessive actin branching which would impair neurite growth and stability. Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of star [...] | 0.927 |
| ACTG1 | VCL | ENSPPYP00000009805 | ENSPPYP00000002699 | ACTG1 isoform 10. | VCL isoform 2. | 0.945 |
| ACTG1 | ZYX | ENSPPYP00000009805 | ENSPPYP00000020326 | ACTG1 isoform 10. | ZYX isoform 1. | 0.913 |
| ACTN1 | ACTB | ENSPPYP00000006748 | ENSPPYP00000019427 | ACTN1 isoform 1. | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | 0.939 |
| ACTN1 | ACTG1 | ENSPPYP00000006748 | ENSPPYP00000009805 | ACTN1 isoform 1. | ACTG1 isoform 10. | 0.944 |
