| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CR201_G0029663 | EPS15 | ENSPPYP00000011487 | ENSPPYP00000001582 | AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] | Epidermal growth factor receptor pathway substrate 15. | 0.985 |
| CR201_G0029663 | GAK | ENSPPYP00000011487 | ENSPPYP00000016219 | AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] | GAK isoform 7. | 0.861 |
| CR201_G0029663 | NUMB | ENSPPYP00000011487 | ENSPPYP00000006785 | AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] | NUMB endocytic adaptor protein. | 0.878 |
| CR201_G0029663 | NUMBL | ENSPPYP00000011487 | ENSPPYP00000011192 | AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] | NUMBL isoform 1. | 0.864 |
| EPS15 | CR201_G0029663 | ENSPPYP00000001582 | ENSPPYP00000011487 | Epidermal growth factor receptor pathway substrate 15. | AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] | 0.985 |
| EPS15 | GAK | ENSPPYP00000001582 | ENSPPYP00000016219 | Epidermal growth factor receptor pathway substrate 15. | GAK isoform 7. | 0.620 |
| EPS15 | NUMB | ENSPPYP00000001582 | ENSPPYP00000006785 | Epidermal growth factor receptor pathway substrate 15. | NUMB endocytic adaptor protein. | 0.833 |
| EPS15 | NUMBL | ENSPPYP00000001582 | ENSPPYP00000011192 | Epidermal growth factor receptor pathway substrate 15. | NUMBL isoform 1. | 0.779 |
| GAK | CR201_G0029663 | ENSPPYP00000016219 | ENSPPYP00000011487 | GAK isoform 7. | AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] | 0.861 |
| GAK | EPS15 | ENSPPYP00000016219 | ENSPPYP00000001582 | GAK isoform 7. | Epidermal growth factor receptor pathway substrate 15. | 0.620 |
| GAK | NUMB | ENSPPYP00000016219 | ENSPPYP00000006785 | GAK isoform 7. | NUMB endocytic adaptor protein. | 0.764 |
| GAK | NUMBL | ENSPPYP00000016219 | ENSPPYP00000011192 | GAK isoform 7. | NUMBL isoform 1. | 0.764 |
| ITCH | NOTCH2 | ENSPPYP00000012212 | ENSPPYP00000001116 | E3 ubiquitin-protein ligase. | NOTCH2 isoform 2. | 0.934 |
| ITCH | NOTCH3 | ENSPPYP00000012212 | ENSPPYP00000010835 | E3 ubiquitin-protein ligase. | NOTCH3 isoform 1. | 0.938 |
| ITCH | NUMB | ENSPPYP00000012212 | ENSPPYP00000006785 | E3 ubiquitin-protein ligase. | NUMB endocytic adaptor protein. | 0.963 |
| ITCH | NUMBL | ENSPPYP00000012212 | ENSPPYP00000011192 | E3 ubiquitin-protein ligase. | NUMBL isoform 1. | 0.918 |
| ITCH | TP53 | ENSPPYP00000012212 | ENSPPYP00000008923 | E3 ubiquitin-protein ligase. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.839 |
| ITCH | TRAF6 | ENSPPYP00000012212 | ENSPPYP00000003845 | E3 ubiquitin-protein ligase. | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. | 0.878 |
| LNX1 | NUMB | ENSPPYP00000016498 | ENSPPYP00000006785 | LNX1 isoform 2. | NUMB endocytic adaptor protein. | 0.914 |
| LNX1 | NUMBL | ENSPPYP00000016498 | ENSPPYP00000011192 | LNX1 isoform 2. | NUMBL isoform 1. | 0.866 |
