| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CA8 | HSD17B14 | ENSPPYP00000020875 | ENSPPYP00000011427 | Carbonic anhydrase 8; Belongs to the alpha-carbonic anhydrase family. | Hydroxysteroid 17-beta dehydrogenase 14. | 0.599 |
| CR201_G0008700 | HSD17B14 | ENSPPYP00000001407 | ENSPPYP00000011427 | ADGRL4 isoform 1; Belongs to the G-protein coupled receptor 2 family. | Hydroxysteroid 17-beta dehydrogenase 14. | 0.659 |
| ECHDC1 | HSD17B12 | ENSPPYP00000024266 | ENSPPYP00000003837 | Ethylmalonyl-CoA decarboxylase; Decarboxylates ethylmalonyl-CoA, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading. Also has methylmalonyl-CoA decarboxylase activity at lower level; Belongs to the enoyl-CoA hydratase/isomerase family. | HSD17B12 isoform 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.427 |
| ECHDC1 | HSD17B14 | ENSPPYP00000024266 | ENSPPYP00000011427 | Ethylmalonyl-CoA decarboxylase; Decarboxylates ethylmalonyl-CoA, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading. Also has methylmalonyl-CoA decarboxylase activity at lower level; Belongs to the enoyl-CoA hydratase/isomerase family. | Hydroxysteroid 17-beta dehydrogenase 14. | 0.590 |
| FCSK | HK1 | ENSPPYP00000024132 | ENSPPYP00000002765 | FUK isoform 2. | Hexokinase-1; Catalyzes the phosphorylation of various hexoses, such as D- glucose, D-glucosamine, D-fructose, D-mannose and 2-deoxy-D-glucose, to hexose 6-phosphate (D-glucose 6-phosphate, D-glucosamine 6-phosphate, D-fructose 6-phosphate, D-mannose 6-phosphate and 2-deoxy-D-glucose 6- phosphate, respectively). Does not phosphorylate N-acetyl-D-glucosamine (By similarity). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (By similarity). Involved in innate immunity and inflammation by acting as a pattern recognition receptor f [...] | 0.831 |
| FCSK | HK2 | ENSPPYP00000024132 | ENSPPYP00000013670 | FUK isoform 2. | HK2 isoform 1. | 0.831 |
| FCSK | HK3 | ENSPPYP00000024132 | ENSPPYP00000017995 | FUK isoform 2. | HK3 isoform 2. | 0.831 |
| FCSK | HKDC1 | ENSPPYP00000024132 | ENSPPYP00000002767 | FUK isoform 2. | Hexokinase domain containing 1. | 0.831 |
| FCSK | HSD17B14 | ENSPPYP00000024132 | ENSPPYP00000011427 | FUK isoform 2. | Hydroxysteroid 17-beta dehydrogenase 14. | 0.900 |
| HK1 | FCSK | ENSPPYP00000002765 | ENSPPYP00000024132 | Hexokinase-1; Catalyzes the phosphorylation of various hexoses, such as D- glucose, D-glucosamine, D-fructose, D-mannose and 2-deoxy-D-glucose, to hexose 6-phosphate (D-glucose 6-phosphate, D-glucosamine 6-phosphate, D-fructose 6-phosphate, D-mannose 6-phosphate and 2-deoxy-D-glucose 6- phosphate, respectively). Does not phosphorylate N-acetyl-D-glucosamine (By similarity). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (By similarity). Involved in innate immunity and inflammation by acting as a pattern recognition receptor f [...] | FUK isoform 2. | 0.831 |
| HK1 | HK2 | ENSPPYP00000002765 | ENSPPYP00000013670 | Hexokinase-1; Catalyzes the phosphorylation of various hexoses, such as D- glucose, D-glucosamine, D-fructose, D-mannose and 2-deoxy-D-glucose, to hexose 6-phosphate (D-glucose 6-phosphate, D-glucosamine 6-phosphate, D-fructose 6-phosphate, D-mannose 6-phosphate and 2-deoxy-D-glucose 6- phosphate, respectively). Does not phosphorylate N-acetyl-D-glucosamine (By similarity). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (By similarity). Involved in innate immunity and inflammation by acting as a pattern recognition receptor f [...] | HK2 isoform 1. | 0.993 |
| HK1 | HK3 | ENSPPYP00000002765 | ENSPPYP00000017995 | Hexokinase-1; Catalyzes the phosphorylation of various hexoses, such as D- glucose, D-glucosamine, D-fructose, D-mannose and 2-deoxy-D-glucose, to hexose 6-phosphate (D-glucose 6-phosphate, D-glucosamine 6-phosphate, D-fructose 6-phosphate, D-mannose 6-phosphate and 2-deoxy-D-glucose 6- phosphate, respectively). Does not phosphorylate N-acetyl-D-glucosamine (By similarity). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (By similarity). Involved in innate immunity and inflammation by acting as a pattern recognition receptor f [...] | HK3 isoform 2. | 0.986 |
| HK1 | HKDC1 | ENSPPYP00000002765 | ENSPPYP00000002767 | Hexokinase-1; Catalyzes the phosphorylation of various hexoses, such as D- glucose, D-glucosamine, D-fructose, D-mannose and 2-deoxy-D-glucose, to hexose 6-phosphate (D-glucose 6-phosphate, D-glucosamine 6-phosphate, D-fructose 6-phosphate, D-mannose 6-phosphate and 2-deoxy-D-glucose 6- phosphate, respectively). Does not phosphorylate N-acetyl-D-glucosamine (By similarity). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (By similarity). Involved in innate immunity and inflammation by acting as a pattern recognition receptor f [...] | Hexokinase domain containing 1. | 0.992 |
| HK1 | HSD17B14 | ENSPPYP00000002765 | ENSPPYP00000011427 | Hexokinase-1; Catalyzes the phosphorylation of various hexoses, such as D- glucose, D-glucosamine, D-fructose, D-mannose and 2-deoxy-D-glucose, to hexose 6-phosphate (D-glucose 6-phosphate, D-glucosamine 6-phosphate, D-fructose 6-phosphate, D-mannose 6-phosphate and 2-deoxy-D-glucose 6- phosphate, respectively). Does not phosphorylate N-acetyl-D-glucosamine (By similarity). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (By similarity). Involved in innate immunity and inflammation by acting as a pattern recognition receptor f [...] | Hydroxysteroid 17-beta dehydrogenase 14. | 0.808 |
| HK2 | FCSK | ENSPPYP00000013670 | ENSPPYP00000024132 | HK2 isoform 1. | FUK isoform 2. | 0.831 |
| HK2 | HK1 | ENSPPYP00000013670 | ENSPPYP00000002765 | HK2 isoform 1. | Hexokinase-1; Catalyzes the phosphorylation of various hexoses, such as D- glucose, D-glucosamine, D-fructose, D-mannose and 2-deoxy-D-glucose, to hexose 6-phosphate (D-glucose 6-phosphate, D-glucosamine 6-phosphate, D-fructose 6-phosphate, D-mannose 6-phosphate and 2-deoxy-D-glucose 6- phosphate, respectively). Does not phosphorylate N-acetyl-D-glucosamine (By similarity). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (By similarity). Involved in innate immunity and inflammation by acting as a pattern recognition receptor f [...] | 0.993 |
| HK2 | HK3 | ENSPPYP00000013670 | ENSPPYP00000017995 | HK2 isoform 1. | HK3 isoform 2. | 0.981 |
| HK2 | HKDC1 | ENSPPYP00000013670 | ENSPPYP00000002767 | HK2 isoform 1. | Hexokinase domain containing 1. | 0.907 |
| HK2 | HSD17B14 | ENSPPYP00000013670 | ENSPPYP00000011427 | HK2 isoform 1. | Hydroxysteroid 17-beta dehydrogenase 14. | 0.808 |
| HK3 | FCSK | ENSPPYP00000017995 | ENSPPYP00000024132 | HK3 isoform 2. | FUK isoform 2. | 0.831 |
