MED25 protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCNC	HAVCR2	ENSPPYP00000018878	ENSPPYP00000017887	CCNC isoform 1; Belongs to the cyclin family.	HAVCR2 isoform 1.	0.981
CCNC	MED1	ENSPPYP00000018878	ENSPPYP00000009539	CCNC isoform 1; Belongs to the cyclin family.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Acts as a coactivator for [...]	0.994
CCNC	MED10	ENSPPYP00000018878	ENSPPYP00000017124	CCNC isoform 1; Belongs to the cyclin family.	Mediator of RNA polymerase II transcription subunit 10; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).	0.994
CCNC	MED12	ENSPPYP00000018878	ENSPPYP00000022889	CCNC isoform 1; Belongs to the cyclin family.	MED12 isoform 3.	0.994
CCNC	MED14	ENSPPYP00000018878	ENSPPYP00000022666	CCNC isoform 1; Belongs to the cyclin family.	Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.995
CCNC	MED19	ENSPPYP00000018878	ENSPPYP00000003751	CCNC isoform 1; Belongs to the cyclin family.	Mediator of RNA polymerase II transcription subunit 19; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.986
CCNC	MED21	ENSPPYP00000018878	ENSPPYP00000004996	CCNC isoform 1; Belongs to the cyclin family.	Mediator of RNA polymerase II transcription subunit 21; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).	0.986
CCNC	MED23	ENSPPYP00000018878	ENSPPYP00000024779	CCNC isoform 1; Belongs to the cyclin family.	Mediator complex subunit 23.	0.994
CCNC	MED24	ENSPPYP00000018878	ENSPPYP00000009518	CCNC isoform 1; Belongs to the cyclin family.	MED24 isoform 12.	0.983
CCNC	MED25	ENSPPYP00000018878	ENSPPYP00000011489	CCNC isoform 1; Belongs to the cyclin family.	MED25 isoform 7.	0.988
HAVCR2	CCNC	ENSPPYP00000017887	ENSPPYP00000018878	HAVCR2 isoform 1.	CCNC isoform 1; Belongs to the cyclin family.	0.981
HAVCR2	MED1	ENSPPYP00000017887	ENSPPYP00000009539	HAVCR2 isoform 1.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Acts as a coactivator for [...]	0.991
HAVCR2	MED10	ENSPPYP00000017887	ENSPPYP00000017124	HAVCR2 isoform 1.	Mediator of RNA polymerase II transcription subunit 10; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).	0.991
HAVCR2	MED12	ENSPPYP00000017887	ENSPPYP00000022889	HAVCR2 isoform 1.	MED12 isoform 3.	0.950
HAVCR2	MED14	ENSPPYP00000017887	ENSPPYP00000022666	HAVCR2 isoform 1.	Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.994
HAVCR2	MED19	ENSPPYP00000017887	ENSPPYP00000003751	HAVCR2 isoform 1.	Mediator of RNA polymerase II transcription subunit 19; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.981
HAVCR2	MED21	ENSPPYP00000017887	ENSPPYP00000004996	HAVCR2 isoform 1.	Mediator of RNA polymerase II transcription subunit 21; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).	0.981
HAVCR2	MED23	ENSPPYP00000017887	ENSPPYP00000024779	HAVCR2 isoform 1.	Mediator complex subunit 23.	0.987
HAVCR2	MED24	ENSPPYP00000017887	ENSPPYP00000009518	HAVCR2 isoform 1.	MED24 isoform 12.	0.987
HAVCR2	MED25	ENSPPYP00000017887	ENSPPYP00000011489	HAVCR2 isoform 1.	MED25 isoform 7.	0.983