| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AMFR | CR201_G0019691 | ENSPPYP00000008318 | ENSPPYP00000011982 | AMFR isoform 1. | SEL1L2 isoform 6. | 0.787 |
| AMFR | DERL1 | ENSPPYP00000008318 | ENSPPYP00000021151 | AMFR isoform 1. | Derlin-1; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the misfolded protein. Also involved in endoplasmic reticulum stress-induced pre- emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for pro [...] | 0.990 |
| AMFR | DERL2 | ENSPPYP00000008318 | ENSPPYP00000008861 | AMFR isoform 1. | Derlin-2; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and misfolded glycoproteins. May also be involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the [...] | 0.967 |
| AMFR | DERL3 | ENSPPYP00000008318 | ENSPPYP00000012977 | AMFR isoform 1. | Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. | 0.779 |
| AMFR | ERLEC1 | ENSPPYP00000008318 | ENSPPYP00000013854 | AMFR isoform 1. | Endoplasmic reticulum lectin 1; Probable lectin that binds selectively to improperly folded lumenal proteins. May function in endoplasmic reticulum quality control and endoplasmic reticulum-associated degradation (ERAD) of both non- glycosylated proteins and glycoproteins (By similarity). | 0.793 |
| AMFR | FAM8A1 | ENSPPYP00000008318 | ENSPPYP00000018182 | AMFR isoform 1. | RDD domain-containing protein. | 0.726 |
| AMFR | OS9 | ENSPPYP00000008318 | ENSPPYP00000005356 | AMFR isoform 1. | OS9 isoform 1. | 0.819 |
| AMFR | SYVN1 | ENSPPYP00000008318 | ENSPPYP00000003559 | AMFR isoform 1. | SYVN1 isoform 3. | 0.876 |
| AMFR | UBE2J1 | ENSPPYP00000008318 | ENSPPYP00000018852 | AMFR isoform 1. | Ubiquitin conjugating enzyme E2 J1. | 0.775 |
| CR201_G0019691 | AMFR | ENSPPYP00000011982 | ENSPPYP00000008318 | SEL1L2 isoform 6. | AMFR isoform 1. | 0.787 |
| CR201_G0019691 | DERL1 | ENSPPYP00000011982 | ENSPPYP00000021151 | SEL1L2 isoform 6. | Derlin-1; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the misfolded protein. Also involved in endoplasmic reticulum stress-induced pre- emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for pro [...] | 0.893 |
| CR201_G0019691 | DERL2 | ENSPPYP00000011982 | ENSPPYP00000008861 | SEL1L2 isoform 6. | Derlin-2; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and misfolded glycoproteins. May also be involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the [...] | 0.825 |
| CR201_G0019691 | DERL3 | ENSPPYP00000011982 | ENSPPYP00000012977 | SEL1L2 isoform 6. | Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. | 0.825 |
| CR201_G0019691 | EDEM1 | ENSPPYP00000011982 | ENSPPYP00000015312 | SEL1L2 isoform 6. | alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. | 0.786 |
| CR201_G0019691 | ERLEC1 | ENSPPYP00000011982 | ENSPPYP00000013854 | SEL1L2 isoform 6. | Endoplasmic reticulum lectin 1; Probable lectin that binds selectively to improperly folded lumenal proteins. May function in endoplasmic reticulum quality control and endoplasmic reticulum-associated degradation (ERAD) of both non- glycosylated proteins and glycoproteins (By similarity). | 0.843 |
| CR201_G0019691 | FAM8A1 | ENSPPYP00000011982 | ENSPPYP00000018182 | SEL1L2 isoform 6. | RDD domain-containing protein. | 0.751 |
| CR201_G0019691 | OS9 | ENSPPYP00000011982 | ENSPPYP00000005356 | SEL1L2 isoform 6. | OS9 isoform 1. | 0.843 |
| CR201_G0019691 | SYVN1 | ENSPPYP00000011982 | ENSPPYP00000003559 | SEL1L2 isoform 6. | SYVN1 isoform 3. | 0.787 |
| CR201_G0019691 | UBE2J1 | ENSPPYP00000011982 | ENSPPYP00000018852 | SEL1L2 isoform 6. | Ubiquitin conjugating enzyme E2 J1. | 0.747 |
| DERL1 | AMFR | ENSPPYP00000021151 | ENSPPYP00000008318 | Derlin-1; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the misfolded protein. Also involved in endoplasmic reticulum stress-induced pre- emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for pro [...] | AMFR isoform 1. | 0.990 |
