| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AK9 | CMPK1 | ENSPPYP00000018934 | ENSPPYP00000001599 | AK9 isoform 2. | UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. | 0.939 |
| AK9 | ENPP1 | ENSPPYP00000018934 | ENSPPYP00000019048 | AK9 isoform 2. | ENPP1 isoform 1. | 0.902 |
| AK9 | ENPP3 | ENSPPYP00000018934 | ENSPPYP00000019047 | AK9 isoform 2. | Ectonucleotide pyrophosphatase/phosphodiesterase family member 3; Hydrolase that metabolizes extracellular nucleotides, including ATP, GTP, UTP and CTP (By similarity). Limits mast cell and basophil responses during inflammation and during the chronic phases of allergic responses by eliminating the extracellular ATP that functions as signaling molecule and activates basophils and mast cells and induces the release of inflammatory cytokines. Metabolizes extracellular ATP in the lumen of the small intestine, and thereby prevents ATP-induced apoptosis of intestinal plasmacytoid dendritic [...] | 0.902 |
| AK9 | ENTPD1 | ENSPPYP00000018934 | ENSPPYP00000002915 | AK9 isoform 2. | ENTPD1 isoform 5; Belongs to the GDA1/CD39 NTPase family. | 0.913 |
| AK9 | ENTPD3 | ENSPPYP00000018934 | ENSPPYP00000015648 | AK9 isoform 2. | ENTPD3 isoform 1; Belongs to the GDA1/CD39 NTPase family. | 0.913 |
| AK9 | ENTPD4 | ENSPPYP00000018934 | ENSPPYP00000020661 | AK9 isoform 2. | ENTPD4 isoform 4; Belongs to the GDA1/CD39 NTPase family. | 0.913 |
| AK9 | ENTPD6 | ENSPPYP00000018934 | ENSPPYP00000012047 | AK9 isoform 2. | ENTPD6 isoform 6; Belongs to the GDA1/CD39 NTPase family. | 0.924 |
| AK9 | ENTPD8 | ENSPPYP00000018934 | ENSPPYP00000022232 | AK9 isoform 2. | Ectonucleoside triphosphate diphosphohydrolase 8; Belongs to the GDA1/CD39 NTPase family. | 0.913 |
| AK9 | ITPA | ENSPPYP00000018934 | ENSPPYP00000012088 | AK9 isoform 2. | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. | 0.930 |
| CMPK1 | AK9 | ENSPPYP00000001599 | ENSPPYP00000018934 | UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. | AK9 isoform 2. | 0.939 |
| CMPK1 | ENPP1 | ENSPPYP00000001599 | ENSPPYP00000019048 | UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. | ENPP1 isoform 1. | 0.904 |
| CMPK1 | ENPP3 | ENSPPYP00000001599 | ENSPPYP00000019047 | UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. | Ectonucleotide pyrophosphatase/phosphodiesterase family member 3; Hydrolase that metabolizes extracellular nucleotides, including ATP, GTP, UTP and CTP (By similarity). Limits mast cell and basophil responses during inflammation and during the chronic phases of allergic responses by eliminating the extracellular ATP that functions as signaling molecule and activates basophils and mast cells and induces the release of inflammatory cytokines. Metabolizes extracellular ATP in the lumen of the small intestine, and thereby prevents ATP-induced apoptosis of intestinal plasmacytoid dendritic [...] | 0.906 |
| CMPK1 | ENTPD1 | ENSPPYP00000001599 | ENSPPYP00000002915 | UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. | ENTPD1 isoform 5; Belongs to the GDA1/CD39 NTPase family. | 0.917 |
| CMPK1 | ENTPD3 | ENSPPYP00000001599 | ENSPPYP00000015648 | UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. | ENTPD3 isoform 1; Belongs to the GDA1/CD39 NTPase family. | 0.947 |
| CMPK1 | ENTPD4 | ENSPPYP00000001599 | ENSPPYP00000020661 | UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. | ENTPD4 isoform 4; Belongs to the GDA1/CD39 NTPase family. | 0.911 |
| CMPK1 | ENTPD6 | ENSPPYP00000001599 | ENSPPYP00000012047 | UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. | ENTPD6 isoform 6; Belongs to the GDA1/CD39 NTPase family. | 0.935 |
| CMPK1 | ENTPD8 | ENSPPYP00000001599 | ENSPPYP00000022232 | UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. | Ectonucleoside triphosphate diphosphohydrolase 8; Belongs to the GDA1/CD39 NTPase family. | 0.917 |
| ENPP1 | AK9 | ENSPPYP00000019048 | ENSPPYP00000018934 | ENPP1 isoform 1. | AK9 isoform 2. | 0.902 |
| ENPP1 | CMPK1 | ENSPPYP00000019048 | ENSPPYP00000001599 | ENPP1 isoform 1. | UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. | 0.904 |
| ENPP1 | ENPP3 | ENSPPYP00000019048 | ENSPPYP00000019047 | ENPP1 isoform 1. | Ectonucleotide pyrophosphatase/phosphodiesterase family member 3; Hydrolase that metabolizes extracellular nucleotides, including ATP, GTP, UTP and CTP (By similarity). Limits mast cell and basophil responses during inflammation and during the chronic phases of allergic responses by eliminating the extracellular ATP that functions as signaling molecule and activates basophils and mast cells and induces the release of inflammatory cytokines. Metabolizes extracellular ATP in the lumen of the small intestine, and thereby prevents ATP-induced apoptosis of intestinal plasmacytoid dendritic [...] | 0.920 |
