STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TGM3TGM3 isoform 1. (693 aa)    
Predicted Functional Partners:
LOR
LOR isoform 1.
   
  
 0.604
CST6
CST6 isoform 1; Belongs to the cystatin family.
      
 0.564
SBSN
SBSN isoform 2.
   
 
 0.552
LGMN
Legumain; Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation. May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system (By similarity).
      
 0.550
CNFN
CNFN isoform 1.
   
  
 0.502
FLG2
Filaggrin family member 2.
   
 
 0.501
CRNN
CRNN isoform 1.
   
  
 0.479
IVL
Involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia.
      
 0.472
MAP6
MAP6 isoform 1.
     
 0.439
CDSN
CDSN isoform 1.
      
 0.424
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
Server load: medium (48%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.