node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FBXO7 | PSMB1 | ENSPPYP00000013112 | ENSPPYP00000019256 | FBXO7 isoform 2. | Proteasome subunit beta. | 0.678 |
FBXO7 | PSMB2 | ENSPPYP00000013112 | ENSPPYP00000001793 | FBXO7 isoform 2. | Proteasome subunit beta. | 0.757 |
FBXO7 | PSMB4 | ENSPPYP00000013112 | ENSPPYP00000001012 | FBXO7 isoform 2. | Proteasome subunit beta; Belongs to the peptidase T1B family. | 0.868 |
FBXO7 | PSMB7 | ENSPPYP00000013112 | ENSPPYP00000021958 | FBXO7 isoform 2. | Proteasome subunit beta. | 0.759 |
FBXO7 | PSMB9 | ENSPPYP00000013112 | ENSPPYP00000019305 | FBXO7 isoform 2. | Proteasome subunit beta. | 0.410 |
FBXO7 | PSMF1 | ENSPPYP00000013112 | ENSPPYP00000012129 | FBXO7 isoform 2. | Proteasome inhibitor PI31 subunit; Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28 (By similarity). | 0.933 |
FBXO7 | PSMG2 | ENSPPYP00000013112 | ENSPPYP00000010079 | FBXO7 isoform 2. | Proteasome assembly chaperone 2; Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. Belongs to the PSMG2 family. | 0.582 |
PSMA1 | PSMA4 | ENSPPYP00000003979 | ENSPPYP00000007603 | Proteasome subunit alpha type-1; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pr [...] | Proteasome subunit alpha type. | 0.999 |
PSMA1 | PSMA7 | ENSPPYP00000003979 | ENSPPYP00000012509 | Proteasome subunit alpha type-1; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pr [...] | Proteasome subunit alpha type-7; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pr [...] | 0.999 |
PSMA1 | PSMB1 | ENSPPYP00000003979 | ENSPPYP00000019256 | Proteasome subunit alpha type-1; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pr [...] | Proteasome subunit beta. | 0.996 |
PSMA1 | PSMB2 | ENSPPYP00000003979 | ENSPPYP00000001793 | Proteasome subunit alpha type-1; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pr [...] | Proteasome subunit beta. | 0.999 |
PSMA1 | PSMB4 | ENSPPYP00000003979 | ENSPPYP00000001012 | Proteasome subunit alpha type-1; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pr [...] | Proteasome subunit beta; Belongs to the peptidase T1B family. | 0.999 |
PSMA1 | PSMB7 | ENSPPYP00000003979 | ENSPPYP00000021958 | Proteasome subunit alpha type-1; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pr [...] | Proteasome subunit beta. | 0.999 |
PSMA1 | PSMB9 | ENSPPYP00000003979 | ENSPPYP00000019305 | Proteasome subunit alpha type-1; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pr [...] | Proteasome subunit beta. | 0.999 |
PSMA1 | PSMF1 | ENSPPYP00000003979 | ENSPPYP00000012129 | Proteasome subunit alpha type-1; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pr [...] | Proteasome inhibitor PI31 subunit; Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28 (By similarity). | 0.856 |
PSMA1 | PSMG2 | ENSPPYP00000003979 | ENSPPYP00000010079 | Proteasome subunit alpha type-1; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pr [...] | Proteasome assembly chaperone 2; Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. Belongs to the PSMG2 family. | 0.934 |
PSMA4 | PSMA1 | ENSPPYP00000007603 | ENSPPYP00000003979 | Proteasome subunit alpha type. | Proteasome subunit alpha type-1; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pr [...] | 0.999 |
PSMA4 | PSMA7 | ENSPPYP00000007603 | ENSPPYP00000012509 | Proteasome subunit alpha type. | Proteasome subunit alpha type-7; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pr [...] | 0.999 |
PSMA4 | PSMB1 | ENSPPYP00000007603 | ENSPPYP00000019256 | Proteasome subunit alpha type. | Proteasome subunit beta. | 0.995 |
PSMA4 | PSMB2 | ENSPPYP00000007603 | ENSPPYP00000001793 | Proteasome subunit alpha type. | Proteasome subunit beta. | 0.998 |