CEP250 protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

CEP250

CEP250 isoform 4. (2389 aa)

Predicted Functional Partners:

PLK1

0.932

ATP5IF1

0.859

NEK2

0.850

PCNT

0.814

CEP135

0.775

CEP78

0.773

NIN

0.771

CEP152

0.723

CNTRL

0.715

REC8

0.673

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATP5IF1	CEP250	ENSPPYP00000001900	ENSPPYP00000012231	ATPase inhibitor, mitochondrial; Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase. Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing FECH to efficiently catalyze the incorporation of iron i [...]	CEP250 isoform 4.	0.859
CEP135	CEP152	ENSPPYP00000016481	ENSPPYP00000007316	CEP135 isoform 2.	CEP152 isoform 2.	0.840
CEP135	CEP250	ENSPPYP00000016481	ENSPPYP00000012231	CEP135 isoform 2.	CEP250 isoform 4.	0.775
CEP135	CEP78	ENSPPYP00000016481	ENSPPYP00000021634	CEP135 isoform 2.	CEP78 isoform 1.	0.464
CEP135	CNTRL	ENSPPYP00000016481	ENSPPYP00000021919	CEP135 isoform 2.	CNTRL isoform 3.	0.711
CEP135	NEK2	ENSPPYP00000016481	ENSPPYP00000000250	CEP135 isoform 2.	NIMA related kinase 2.	0.482
CEP135	NIN	ENSPPYP00000016481	ENSPPYP00000006598	CEP135 isoform 2.	NIN isoform 1.	0.588
CEP135	PCNT	ENSPPYP00000016481	ENSPPYP00000012874	CEP135 isoform 2.	PCNT isoform 1.	0.706
CEP135	PLK1	ENSPPYP00000016481	ENSPPYP00000008136	CEP135 isoform 2.	Serine/threonine-protein kinase PLK.	0.949
CEP152	CEP135	ENSPPYP00000007316	ENSPPYP00000016481	CEP152 isoform 2.	CEP135 isoform 2.	0.840
CEP152	CEP250	ENSPPYP00000007316	ENSPPYP00000012231	CEP152 isoform 2.	CEP250 isoform 4.	0.723
CEP152	CEP78	ENSPPYP00000007316	ENSPPYP00000021634	CEP152 isoform 2.	CEP78 isoform 1.	0.451
CEP152	NEK2	ENSPPYP00000007316	ENSPPYP00000000250	CEP152 isoform 2.	NIMA related kinase 2.	0.493
CEP152	PCNT	ENSPPYP00000007316	ENSPPYP00000012874	CEP152 isoform 2.	PCNT isoform 1.	0.866
CEP152	PLK1	ENSPPYP00000007316	ENSPPYP00000008136	CEP152 isoform 2.	Serine/threonine-protein kinase PLK.	0.876
CEP250	ATP5IF1	ENSPPYP00000012231	ENSPPYP00000001900	CEP250 isoform 4.	ATPase inhibitor, mitochondrial; Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase. Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing FECH to efficiently catalyze the incorporation of iron i [...]	0.859
CEP250	CEP135	ENSPPYP00000012231	ENSPPYP00000016481	CEP250 isoform 4.	CEP135 isoform 2.	0.775
CEP250	CEP152	ENSPPYP00000012231	ENSPPYP00000007316	CEP250 isoform 4.	CEP152 isoform 2.	0.723
CEP250	CEP78	ENSPPYP00000012231	ENSPPYP00000021634	CEP250 isoform 4.	CEP78 isoform 1.	0.773
CEP250	CNTRL	ENSPPYP00000012231	ENSPPYP00000021919	CEP250 isoform 4.	CNTRL isoform 3.	0.715