| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BRAF | RAF1 | ENSPPYP00000020265 | ENSPPYP00000014975 | BRAF isoform 1. | RAF proto-oncogene serine/threonine-protein kinase; Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal- regulated kin [...] | 0.999 |
| BRAF | SFN | ENSPPYP00000020265 | ENSPPYP00000001937 | BRAF isoform 1. | SFN isoform 1; Belongs to the 14-3-3 family. | 0.867 |
| BRAF | YWHAB | ENSPPYP00000020265 | ENSPPYP00000012330 | BRAF isoform 1. | 14-3-3 protein beta/alpha, N-terminally processed; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by [...] | 0.997 |
| BRAF | YWHAE | ENSPPYP00000020265 | ENSPPYP00000008753 | BRAF isoform 1. | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. | 0.978 |
| BRAF | YWHAG | ENSPPYP00000020265 | ENSPPYP00000019583 | BRAF isoform 1. | 14-3-3 protein gamma, N-terminally processed; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner; Belongs to the 14-3-3 family. | 0.983 |
| BRAF | YWHAH | ENSPPYP00000020265 | ENSPPYP00000013101 | BRAF isoform 1. | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta; Belongs to the 14-3-3 family. | 0.988 |
| BRAF | YWHAQ | ENSPPYP00000020265 | ENSPPYP00000014137 | BRAF isoform 1. | 14-3-3 protein theta; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1 (By similarity). | 0.979 |
| CDC25B | CDC25C | ENSPPYP00000012075 | ENSPPYP00000017694 | Cell division cycle 25B. | Cell division cycle 25C. | 0.962 |
| CDC25B | SFN | ENSPPYP00000012075 | ENSPPYP00000001937 | Cell division cycle 25B. | SFN isoform 1; Belongs to the 14-3-3 family. | 0.719 |
| CDC25B | YWHAB | ENSPPYP00000012075 | ENSPPYP00000012330 | Cell division cycle 25B. | 14-3-3 protein beta/alpha, N-terminally processed; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by [...] | 0.995 |
| CDC25B | YWHAE | ENSPPYP00000012075 | ENSPPYP00000008753 | Cell division cycle 25B. | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. | 0.995 |
| CDC25B | YWHAG | ENSPPYP00000012075 | ENSPPYP00000019583 | Cell division cycle 25B. | 14-3-3 protein gamma, N-terminally processed; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner; Belongs to the 14-3-3 family. | 0.984 |
| CDC25B | YWHAH | ENSPPYP00000012075 | ENSPPYP00000013101 | Cell division cycle 25B. | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta; Belongs to the 14-3-3 family. | 0.985 |
| CDC25B | YWHAQ | ENSPPYP00000012075 | ENSPPYP00000014137 | Cell division cycle 25B. | 14-3-3 protein theta; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1 (By similarity). | 0.987 |
| CDC25C | CDC25B | ENSPPYP00000017694 | ENSPPYP00000012075 | Cell division cycle 25C. | Cell division cycle 25B. | 0.962 |
| CDC25C | RAF1 | ENSPPYP00000017694 | ENSPPYP00000014975 | Cell division cycle 25C. | RAF proto-oncogene serine/threonine-protein kinase; Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal- regulated kin [...] | 0.416 |
| CDC25C | SFN | ENSPPYP00000017694 | ENSPPYP00000001937 | Cell division cycle 25C. | SFN isoform 1; Belongs to the 14-3-3 family. | 0.594 |
| CDC25C | YWHAB | ENSPPYP00000017694 | ENSPPYP00000012330 | Cell division cycle 25C. | 14-3-3 protein beta/alpha, N-terminally processed; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by [...] | 0.994 |
| CDC25C | YWHAE | ENSPPYP00000017694 | ENSPPYP00000008753 | Cell division cycle 25C. | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. | 0.998 |
| CDC25C | YWHAG | ENSPPYP00000017694 | ENSPPYP00000019583 | Cell division cycle 25C. | 14-3-3 protein gamma, N-terminally processed; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner; Belongs to the 14-3-3 family. | 0.983 |
