STK4 protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

STK4

STK4 isoform 1. (474 aa)

Predicted Functional Partners:

RASSF1

0.995

SAV1

0.990

STK3

0.986

MOB1A

0.984

CASP3

0.968

CR201_G0022133

0.954

FOXO3

0.932

RASSF2

0.927

FOXO1

0.921

FOXO6

0.915

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CASP3	FOXO1	ENSPPYP00000017020	ENSPPYP00000006042	CASP3 isoform 1; Belongs to the peptidase C14A family.	FOXO1 isoform 1.	0.456
CASP3	FOXO3	ENSPPYP00000017020	ENSPPYP00000018917	CASP3 isoform 1; Belongs to the peptidase C14A family.	FOXO3 isoform 1.	0.497
CASP3	SAV1	ENSPPYP00000017020	ENSPPYP00000006597	CASP3 isoform 1; Belongs to the peptidase C14A family.	Salvador family WW domain containing protein 1.	0.656
CASP3	STK3	ENSPPYP00000017020	ENSPPYP00000021064	CASP3 isoform 1; Belongs to the peptidase C14A family.	STK3 isoform 3.	0.966
CASP3	STK4	ENSPPYP00000017020	ENSPPYP00000012335	CASP3 isoform 1; Belongs to the peptidase C14A family.	STK4 isoform 1.	0.968
CR201_G0022133	RASSF1	ENSPPYP00000000306	ENSPPYP00000015490	RASSF5 isoform 7.	RASSF1 isoform 4.	0.906
CR201_G0022133	RASSF2	ENSPPYP00000000306	ENSPPYP00000012063	RASSF5 isoform 7.	RASSF2 isoform 1.	0.798
CR201_G0022133	SAV1	ENSPPYP00000000306	ENSPPYP00000006597	RASSF5 isoform 7.	Salvador family WW domain containing protein 1.	0.640
CR201_G0022133	STK3	ENSPPYP00000000306	ENSPPYP00000021064	RASSF5 isoform 7.	STK3 isoform 3.	0.899
CR201_G0022133	STK4	ENSPPYP00000000306	ENSPPYP00000012335	RASSF5 isoform 7.	STK4 isoform 1.	0.954
FOXO1	CASP3	ENSPPYP00000006042	ENSPPYP00000017020	FOXO1 isoform 1.	CASP3 isoform 1; Belongs to the peptidase C14A family.	0.456
FOXO1	FOXO3	ENSPPYP00000006042	ENSPPYP00000018917	FOXO1 isoform 1.	FOXO3 isoform 1.	0.992
FOXO1	STK4	ENSPPYP00000006042	ENSPPYP00000012335	FOXO1 isoform 1.	STK4 isoform 1.	0.921
FOXO3	CASP3	ENSPPYP00000018917	ENSPPYP00000017020	FOXO3 isoform 1.	CASP3 isoform 1; Belongs to the peptidase C14A family.	0.497
FOXO3	FOXO1	ENSPPYP00000018917	ENSPPYP00000006042	FOXO3 isoform 1.	FOXO1 isoform 1.	0.992
FOXO3	STK4	ENSPPYP00000018917	ENSPPYP00000012335	FOXO3 isoform 1.	STK4 isoform 1.	0.932
FOXO6	STK4	ENSPPYP00000001709	ENSPPYP00000012335	FOXO6 isoform 2.	STK4 isoform 1.	0.915
MOB1A	SAV1	ENSPPYP00000013698	ENSPPYP00000006597	MOB kinase activator 1A; Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellu [...]	Salvador family WW domain containing protein 1.	0.887
MOB1A	STK3	ENSPPYP00000013698	ENSPPYP00000021064	MOB kinase activator 1A; Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellu [...]	STK3 isoform 3.	0.996
MOB1A	STK4	ENSPPYP00000013698	ENSPPYP00000012335	MOB kinase activator 1A; Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellu [...]	STK4 isoform 1.	0.984