| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BTRC | EZH2 | ENSPPYP00000003001 | ENSPPYP00000023646 | BTRC isoform 2. | EZH2 isoform 5. | 0.605 |
| BTRC | GSK3B | ENSPPYP00000003001 | ENSPPYP00000015105 | BTRC isoform 2. | GSK3B isoform 2; Belongs to the protein kinase superfamily. | 0.929 |
| BTRC | HDAC1 | ENSPPYP00000003001 | ENSPPYP00000001838 | BTRC isoform 2. | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium st [...] | 0.408 |
| BTRC | SNAI1 | ENSPPYP00000003001 | ENSPPYP00000012428 | BTRC isoform 2. | SNAI1 isoform 1. | 0.932 |
| DNMT1 | EZH2 | ENSPPYP00000010706 | ENSPPYP00000023646 | DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | EZH2 isoform 5. | 0.983 |
| DNMT1 | HDAC1 | ENSPPYP00000010706 | ENSPPYP00000001838 | DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium st [...] | 0.988 |
| DNMT1 | HDAC2 | ENSPPYP00000010706 | ENSPPYP00000018964 | DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | Histone deacetylase 2. | 0.962 |
| DNMT1 | KDM1A | ENSPPYP00000010706 | ENSPPYP00000002023 | DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. | 0.886 |
| DNMT1 | SNAI1 | ENSPPYP00000010706 | ENSPPYP00000012428 | DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | SNAI1 isoform 1. | 0.842 |
| EZH2 | BTRC | ENSPPYP00000023646 | ENSPPYP00000003001 | EZH2 isoform 5. | BTRC isoform 2. | 0.605 |
| EZH2 | DNMT1 | ENSPPYP00000023646 | ENSPPYP00000010706 | EZH2 isoform 5. | DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | 0.983 |
| EZH2 | HDAC1 | ENSPPYP00000023646 | ENSPPYP00000001838 | EZH2 isoform 5. | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium st [...] | 0.965 |
| EZH2 | HDAC2 | ENSPPYP00000023646 | ENSPPYP00000018964 | EZH2 isoform 5. | Histone deacetylase 2. | 0.935 |
| EZH2 | KDM1A | ENSPPYP00000023646 | ENSPPYP00000002023 | EZH2 isoform 5. | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. | 0.693 |
| EZH2 | RCOR1 | ENSPPYP00000023646 | ENSPPYP00000007002 | EZH2 isoform 5. | RCOR1 isoform 1. | 0.579 |
| EZH2 | SNAI1 | ENSPPYP00000023646 | ENSPPYP00000012428 | EZH2 isoform 5. | SNAI1 isoform 1. | 0.856 |
| GSE1 | HDAC1 | ENSPPYP00000008592 | ENSPPYP00000001838 | GSE1 isoform 3. | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium st [...] | 0.813 |
| GSE1 | HDAC2 | ENSPPYP00000008592 | ENSPPYP00000018964 | GSE1 isoform 3. | Histone deacetylase 2. | 0.804 |
| GSE1 | HMG20A | ENSPPYP00000008592 | ENSPPYP00000007582 | GSE1 isoform 3. | High mobility group 20A. | 0.947 |
| GSE1 | KDM1A | ENSPPYP00000008592 | ENSPPYP00000002023 | GSE1 isoform 3. | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. | 0.827 |
