| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ABL1 | RTF2 | ENSPPYP00000022265 | ENSPPYP00000012459 | Tyrosine-protein kinase. | Replication termination factor 2; Replication termination factor which is a component of the elongating replisome. Required for ATR pathway signaling upon DNA damage and has a positive activity during DNA replication. Might function to facilitate fork pausing at replication fork barriers like the rDNA. May be globally required to stimulate ATR signaling after the fork stalls or encounters a lesion. Interacts with nascent DNA. Belongs to the rtf2 family. | 0.519 |
| CATSPER1 | MAGEB16 | ENSPPYP00000003513 | ENSPPYP00000022635 | CATSPER1 isoform 1. | MAGEB16 isoform 5. | 0.709 |
| CATSPER1 | RTF2 | ENSPPYP00000003513 | ENSPPYP00000012459 | CATSPER1 isoform 1. | Replication termination factor 2; Replication termination factor which is a component of the elongating replisome. Required for ATR pathway signaling upon DNA damage and has a positive activity during DNA replication. Might function to facilitate fork pausing at replication fork barriers like the rDNA. May be globally required to stimulate ATR signaling after the fork stalls or encounters a lesion. Interacts with nascent DNA. Belongs to the rtf2 family. | 0.517 |
| CATSPER1 | TULP2 | ENSPPYP00000003513 | ENSPPYP00000011430 | CATSPER1 isoform 1. | TULP2 isoform 2; Belongs to the TUB family. | 0.748 |
| CATSPER1 | ZFAND4 | ENSPPYP00000003513 | ENSPPYP00000002604 | CATSPER1 isoform 1. | Zinc finger AN1-type containing 4. | 0.703 |
| DDI1 | RTF2 | ENSPPYP00000004371 | ENSPPYP00000012459 | DNA damage inducible 1 homolog 1. | Replication termination factor 2; Replication termination factor which is a component of the elongating replisome. Required for ATR pathway signaling upon DNA damage and has a positive activity during DNA replication. Might function to facilitate fork pausing at replication fork barriers like the rDNA. May be globally required to stimulate ATR signaling after the fork stalls or encounters a lesion. Interacts with nascent DNA. Belongs to the rtf2 family. | 0.545 |
| FLYWCH2 | RTF2 | ENSPPYP00000007931 | ENSPPYP00000012459 | FLYWCH family member 2. | Replication termination factor 2; Replication termination factor which is a component of the elongating replisome. Required for ATR pathway signaling upon DNA damage and has a positive activity during DNA replication. Might function to facilitate fork pausing at replication fork barriers like the rDNA. May be globally required to stimulate ATR signaling after the fork stalls or encounters a lesion. Interacts with nascent DNA. Belongs to the rtf2 family. | 0.591 |
| FLYWCH2 | YARS1 | ENSPPYP00000007931 | ENSPPYP00000001828 | FLYWCH family member 2. | Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.788 |
| MAGEB16 | CATSPER1 | ENSPPYP00000022635 | ENSPPYP00000003513 | MAGEB16 isoform 5. | CATSPER1 isoform 1. | 0.709 |
| MAGEB16 | RTF2 | ENSPPYP00000022635 | ENSPPYP00000012459 | MAGEB16 isoform 5. | Replication termination factor 2; Replication termination factor which is a component of the elongating replisome. Required for ATR pathway signaling upon DNA damage and has a positive activity during DNA replication. Might function to facilitate fork pausing at replication fork barriers like the rDNA. May be globally required to stimulate ATR signaling after the fork stalls or encounters a lesion. Interacts with nascent DNA. Belongs to the rtf2 family. | 0.570 |
| MAGEB16 | TULP2 | ENSPPYP00000022635 | ENSPPYP00000011430 | MAGEB16 isoform 5. | TULP2 isoform 2; Belongs to the TUB family. | 0.827 |
| MAGEB16 | ZFAND4 | ENSPPYP00000022635 | ENSPPYP00000002604 | MAGEB16 isoform 5. | Zinc finger AN1-type containing 4. | 0.766 |
| RTF1 | RTF2 | ENSPPYP00000007219 | ENSPPYP00000012459 | RNA polymerase-associated protein RTF1 homolog; Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser- 5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription [...] | Replication termination factor 2; Replication termination factor which is a component of the elongating replisome. Required for ATR pathway signaling upon DNA damage and has a positive activity during DNA replication. Might function to facilitate fork pausing at replication fork barriers like the rDNA. May be globally required to stimulate ATR signaling after the fork stalls or encounters a lesion. Interacts with nascent DNA. Belongs to the rtf2 family. | 0.563 |
| RTF2 | ABL1 | ENSPPYP00000012459 | ENSPPYP00000022265 | Replication termination factor 2; Replication termination factor which is a component of the elongating replisome. Required for ATR pathway signaling upon DNA damage and has a positive activity during DNA replication. Might function to facilitate fork pausing at replication fork barriers like the rDNA. May be globally required to stimulate ATR signaling after the fork stalls or encounters a lesion. Interacts with nascent DNA. Belongs to the rtf2 family. | Tyrosine-protein kinase. | 0.519 |
| RTF2 | CATSPER1 | ENSPPYP00000012459 | ENSPPYP00000003513 | Replication termination factor 2; Replication termination factor which is a component of the elongating replisome. Required for ATR pathway signaling upon DNA damage and has a positive activity during DNA replication. Might function to facilitate fork pausing at replication fork barriers like the rDNA. May be globally required to stimulate ATR signaling after the fork stalls or encounters a lesion. Interacts with nascent DNA. Belongs to the rtf2 family. | CATSPER1 isoform 1. | 0.517 |
| RTF2 | DDI1 | ENSPPYP00000012459 | ENSPPYP00000004371 | Replication termination factor 2; Replication termination factor which is a component of the elongating replisome. Required for ATR pathway signaling upon DNA damage and has a positive activity during DNA replication. Might function to facilitate fork pausing at replication fork barriers like the rDNA. May be globally required to stimulate ATR signaling after the fork stalls or encounters a lesion. Interacts with nascent DNA. Belongs to the rtf2 family. | DNA damage inducible 1 homolog 1. | 0.545 |
| RTF2 | FLYWCH2 | ENSPPYP00000012459 | ENSPPYP00000007931 | Replication termination factor 2; Replication termination factor which is a component of the elongating replisome. Required for ATR pathway signaling upon DNA damage and has a positive activity during DNA replication. Might function to facilitate fork pausing at replication fork barriers like the rDNA. May be globally required to stimulate ATR signaling after the fork stalls or encounters a lesion. Interacts with nascent DNA. Belongs to the rtf2 family. | FLYWCH family member 2. | 0.591 |
| RTF2 | MAGEB16 | ENSPPYP00000012459 | ENSPPYP00000022635 | Replication termination factor 2; Replication termination factor which is a component of the elongating replisome. Required for ATR pathway signaling upon DNA damage and has a positive activity during DNA replication. Might function to facilitate fork pausing at replication fork barriers like the rDNA. May be globally required to stimulate ATR signaling after the fork stalls or encounters a lesion. Interacts with nascent DNA. Belongs to the rtf2 family. | MAGEB16 isoform 5. | 0.570 |
| RTF2 | RTF1 | ENSPPYP00000012459 | ENSPPYP00000007219 | Replication termination factor 2; Replication termination factor which is a component of the elongating replisome. Required for ATR pathway signaling upon DNA damage and has a positive activity during DNA replication. Might function to facilitate fork pausing at replication fork barriers like the rDNA. May be globally required to stimulate ATR signaling after the fork stalls or encounters a lesion. Interacts with nascent DNA. Belongs to the rtf2 family. | RNA polymerase-associated protein RTF1 homolog; Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser- 5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription [...] | 0.563 |
| RTF2 | TRMT1 | ENSPPYP00000012459 | ENSPPYP00000010786 | Replication termination factor 2; Replication termination factor which is a component of the elongating replisome. Required for ATR pathway signaling upon DNA damage and has a positive activity during DNA replication. Might function to facilitate fork pausing at replication fork barriers like the rDNA. May be globally required to stimulate ATR signaling after the fork stalls or encounters a lesion. Interacts with nascent DNA. Belongs to the rtf2 family. | tRNA (guanine(26)-N(2))-dimethyltransferase. | 0.915 |
