PCMTD2 protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

PCMTD2

Protein-L-isoaspartate O-methyltransferase domain-containing protein 2. (361 aa)

Predicted Functional Partners:

CUL5

0.813

ANKEF1

0.724

TBC1D17

0.621

FBXL4

0.613

GINS1

0.602

RNF7

0.584

SLC2A6

0.512

FICD

0.509

ZMYND8

0.503

PRSS37

0.495

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANKEF1	FICD	ENSPPYP00000011968	ENSPPYP00000005610	ANKEF1 isoform 1.	FICD isoform 3.	0.634
ANKEF1	GINS1	ENSPPYP00000011968	ENSPPYP00000012052	ANKEF1 isoform 1.	GINS complex subunit 1.	0.678
ANKEF1	PCMTD2	ENSPPYP00000011968	ENSPPYP00000012583	ANKEF1 isoform 1.	Protein-L-isoaspartate O-methyltransferase domain-containing protein 2.	0.724
ANKEF1	ZMYND8	ENSPPYP00000011968	ENSPPYP00000012404	ANKEF1 isoform 1.	ZMYND8 isoform 16.	0.632
CUL5	PCMTD2	ENSPPYP00000004398	ENSPPYP00000012583	Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...]	Protein-L-isoaspartate O-methyltransferase domain-containing protein 2.	0.813
CUL5	RNF7	ENSPPYP00000004398	ENSPPYP00000015846	Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...]	Ring finger protein 7.	0.998
FBXL4	PCMTD2	ENSPPYP00000018873	ENSPPYP00000012583	F-box and leucine rich repeat protein 4.	Protein-L-isoaspartate O-methyltransferase domain-containing protein 2.	0.613
FBXL4	RNF7	ENSPPYP00000018873	ENSPPYP00000015846	F-box and leucine rich repeat protein 4.	Ring finger protein 7.	0.491
FBXL4	TBC1D17	ENSPPYP00000018873	ENSPPYP00000011494	F-box and leucine rich repeat protein 4.	TBC1 domain family member 17.	0.490
FICD	ANKEF1	ENSPPYP00000005610	ENSPPYP00000011968	FICD isoform 3.	ANKEF1 isoform 1.	0.634
FICD	GINS1	ENSPPYP00000005610	ENSPPYP00000012052	FICD isoform 3.	GINS complex subunit 1.	0.408
FICD	PCMTD2	ENSPPYP00000005610	ENSPPYP00000012583	FICD isoform 3.	Protein-L-isoaspartate O-methyltransferase domain-containing protein 2.	0.509
FICD	ZMYND8	ENSPPYP00000005610	ENSPPYP00000012404	FICD isoform 3.	ZMYND8 isoform 16.	0.615
GINS1	ANKEF1	ENSPPYP00000012052	ENSPPYP00000011968	GINS complex subunit 1.	ANKEF1 isoform 1.	0.678
GINS1	FICD	ENSPPYP00000012052	ENSPPYP00000005610	GINS complex subunit 1.	FICD isoform 3.	0.408
GINS1	PCMTD2	ENSPPYP00000012052	ENSPPYP00000012583	GINS complex subunit 1.	Protein-L-isoaspartate O-methyltransferase domain-containing protein 2.	0.602
GINS1	ZMYND8	ENSPPYP00000012052	ENSPPYP00000012404	GINS complex subunit 1.	ZMYND8 isoform 16.	0.409
PCMTD2	ANKEF1	ENSPPYP00000012583	ENSPPYP00000011968	Protein-L-isoaspartate O-methyltransferase domain-containing protein 2.	ANKEF1 isoform 1.	0.724
PCMTD2	CUL5	ENSPPYP00000012583	ENSPPYP00000004398	Protein-L-isoaspartate O-methyltransferase domain-containing protein 2.	Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...]	0.813
PCMTD2	FBXL4	ENSPPYP00000012583	ENSPPYP00000018873	Protein-L-isoaspartate O-methyltransferase domain-containing protein 2.	F-box and leucine rich repeat protein 4.	0.613