| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| APBB1 | APLP2 | ENSPPYP00000004064 | ENSPPYP00000004646 | APBB1 isoform 1. | Amyloid beta precursor like protein 2. | 0.903 |
| APBB1 | APP | ENSPPYP00000004064 | ENSPPYP00000012629 | APBB1 isoform 1. | APP isoform 3. | 0.970 |
| APBB1 | BACE1 | ENSPPYP00000004064 | ENSPPYP00000004482 | APBB1 isoform 1. | Beta-secretase 1; Belongs to the peptidase A1 family. | 0.496 |
| APLP2 | APBB1 | ENSPPYP00000004646 | ENSPPYP00000004064 | Amyloid beta precursor like protein 2. | APBB1 isoform 1. | 0.903 |
| APLP2 | APOE | ENSPPYP00000004646 | ENSPPYP00000011298 | Amyloid beta precursor like protein 2. | Apolipoprotein E. | 0.779 |
| APLP2 | APP | ENSPPYP00000004646 | ENSPPYP00000012629 | Amyloid beta precursor like protein 2. | APP isoform 3. | 0.970 |
| APLP2 | BACE1 | ENSPPYP00000004646 | ENSPPYP00000004482 | Amyloid beta precursor like protein 2. | Beta-secretase 1; Belongs to the peptidase A1 family. | 0.734 |
| APLP2 | CLU | ENSPPYP00000004646 | ENSPPYP00000020696 | Amyloid beta precursor like protein 2. | Clusterin; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. | 0.749 |
| APLP2 | MAPT | ENSPPYP00000004646 | ENSPPYP00000009325 | Amyloid beta precursor like protein 2. | Microtubule-associated protein. | 0.608 |
| APLP2 | PRNP | ENSPPYP00000004646 | ENSPPYP00000012064 | Amyloid beta precursor like protein 2. | Major prion protein; Belongs to the prion family. | 0.778 |
| APLP2 | PSEN1 | ENSPPYP00000004646 | ENSPPYP00000006781 | Amyloid beta precursor like protein 2. | Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. Stimulates cell-cell adhesion via its interaction with CDH1; this stabili [...] | 0.649 |
| APLP2 | SNCA | ENSPPYP00000004646 | ENSPPYP00000016673 | Amyloid beta precursor like protein 2. | Alpha-synuclein; May be involved in the regulation of dopamine release and transport; Belongs to the synuclein family. | 0.747 |
| APLP2 | SORL1 | ENSPPYP00000004646 | ENSPPYP00000004559 | Amyloid beta precursor like protein 2. | SORL1 isoform 1. | 0.858 |
| APOE | APLP2 | ENSPPYP00000011298 | ENSPPYP00000004646 | Apolipoprotein E. | Amyloid beta precursor like protein 2. | 0.779 |
| APOE | APP | ENSPPYP00000011298 | ENSPPYP00000012629 | Apolipoprotein E. | APP isoform 3. | 0.980 |
| APOE | BACE1 | ENSPPYP00000011298 | ENSPPYP00000004482 | Apolipoprotein E. | Beta-secretase 1; Belongs to the peptidase A1 family. | 0.500 |
| APOE | CLU | ENSPPYP00000011298 | ENSPPYP00000020696 | Apolipoprotein E. | Clusterin; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. | 0.743 |
| APOE | MAPT | ENSPPYP00000011298 | ENSPPYP00000009325 | Apolipoprotein E. | Microtubule-associated protein. | 0.925 |
| APOE | PRNP | ENSPPYP00000011298 | ENSPPYP00000012064 | Apolipoprotein E. | Major prion protein; Belongs to the prion family. | 0.434 |
| APOE | PSEN1 | ENSPPYP00000011298 | ENSPPYP00000006781 | Apolipoprotein E. | Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. Stimulates cell-cell adhesion via its interaction with CDH1; this stabili [...] | 0.719 |
