PDE9A protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

PDE9A

Phosphodiesterase. (551 aa)

Predicted Functional Partners:

GMPR

0.913

HPRT1

0.901

GUK1

0.900

GMPS

0.900

GUCY1A2

0.876

TRIM32

0.835

GUCY1A1

0.813

PHYHIPL

0.798

NPR2

0.783

NPR1

0.764

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GMPR	GMPS	ENSPPYP00000018176	ENSPPYP00000015909	GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.	GMP synthase [glutamine-hydrolyzing].	0.990
GMPR	GUK1	ENSPPYP00000018176	ENSPPYP00000000143	GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.	GUK1 isoform 3.	0.929
GMPR	HPRT1	ENSPPYP00000018176	ENSPPYP00000023211	GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.	0.924
GMPR	PDE9A	ENSPPYP00000018176	ENSPPYP00000012789	GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.	Phosphodiesterase.	0.913
GMPS	GMPR	ENSPPYP00000015909	ENSPPYP00000018176	GMP synthase [glutamine-hydrolyzing].	GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.	0.990
GMPS	GUK1	ENSPPYP00000015909	ENSPPYP00000000143	GMP synthase [glutamine-hydrolyzing].	GUK1 isoform 3.	0.974
GMPS	HPRT1	ENSPPYP00000015909	ENSPPYP00000023211	GMP synthase [glutamine-hydrolyzing].	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.	0.934
GMPS	PDE9A	ENSPPYP00000015909	ENSPPYP00000012789	GMP synthase [glutamine-hydrolyzing].	Phosphodiesterase.	0.900
GUCY1A1	GUCY1A2	ENSPPYP00000017082	ENSPPYP00000004387	GUCY1A3 isoform 10; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	GUCY1A2 isoform 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.613
GUCY1A1	PDE9A	ENSPPYP00000017082	ENSPPYP00000012789	GUCY1A3 isoform 10; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Phosphodiesterase.	0.813
GUCY1A2	GUCY1A1	ENSPPYP00000004387	ENSPPYP00000017082	GUCY1A2 isoform 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	GUCY1A3 isoform 10; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.613
GUCY1A2	PDE9A	ENSPPYP00000004387	ENSPPYP00000012789	GUCY1A2 isoform 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Phosphodiesterase.	0.876
GUK1	GMPR	ENSPPYP00000000143	ENSPPYP00000018176	GUK1 isoform 3.	GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.	0.929
GUK1	GMPS	ENSPPYP00000000143	ENSPPYP00000015909	GUK1 isoform 3.	GMP synthase [glutamine-hydrolyzing].	0.974
GUK1	HPRT1	ENSPPYP00000000143	ENSPPYP00000023211	GUK1 isoform 3.	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.	0.932
GUK1	PDE9A	ENSPPYP00000000143	ENSPPYP00000012789	GUK1 isoform 3.	Phosphodiesterase.	0.900
HPRT1	GMPR	ENSPPYP00000023211	ENSPPYP00000018176	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.	GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.	0.924
HPRT1	GMPS	ENSPPYP00000023211	ENSPPYP00000015909	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.	GMP synthase [glutamine-hydrolyzing].	0.934
HPRT1	GUK1	ENSPPYP00000023211	ENSPPYP00000000143	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.	GUK1 isoform 3.	0.932
HPRT1	PDE9A	ENSPPYP00000023211	ENSPPYP00000012789	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.	Phosphodiesterase.	0.901