| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AMFR | AUP1 | ENSPPYP00000008318 | ENSPPYP00000013677 | AMFR isoform 1. | AUP1 lipid droplet regulating VLDL assembly factor. | 0.759 |
| AMFR | MARCHF6 | ENSPPYP00000008318 | ENSPPYP00000017141 | AMFR isoform 1. | E3 ubiquitin-protein ligase MARCHF6; E3 ubiquitin-protein ligase that promotes 'Lys-48'-linked ubiquitination of target proteins, leading to their proteasomal degradation. Promotes ubiquitination of DIO2, leading to its degradation. Promotes ubiquitination of SQLE, leading to its degradation. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May cooperate with UBE2G1. | 0.794 |
| AMFR | SYVN1 | ENSPPYP00000008318 | ENSPPYP00000003559 | AMFR isoform 1. | SYVN1 isoform 3. | 0.876 |
| AMFR | UBC | ENSPPYP00000008318 | ENSPPYP00000005811 | AMFR isoform 1. | UBC isoform 2. | 0.995 |
| AMFR | UBE2G1 | ENSPPYP00000008318 | ENSPPYP00000008817 | AMFR isoform 1. | Ubiquitin conjugating enzyme E2 G1; Belongs to the ubiquitin-conjugating enzyme family. | 0.939 |
| AMFR | UBE2G2 | ENSPPYP00000008318 | ENSPPYP00000012839 | AMFR isoform 1. | Ubiquitin-conjugating enzyme E2 G2; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'- linked polyubiquitination. Involved in endoplasmic reticulum-associated degradation (ERAD). | 0.975 |
| AUP1 | AMFR | ENSPPYP00000013677 | ENSPPYP00000008318 | AUP1 lipid droplet regulating VLDL assembly factor. | AMFR isoform 1. | 0.759 |
| AUP1 | SYVN1 | ENSPPYP00000013677 | ENSPPYP00000003559 | AUP1 lipid droplet regulating VLDL assembly factor. | SYVN1 isoform 3. | 0.923 |
| AUP1 | UBE2G2 | ENSPPYP00000013677 | ENSPPYP00000012839 | AUP1 lipid droplet regulating VLDL assembly factor. | Ubiquitin-conjugating enzyme E2 G2; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'- linked polyubiquitination. Involved in endoplasmic reticulum-associated degradation (ERAD). | 0.954 |
| MARCHF6 | AMFR | ENSPPYP00000017141 | ENSPPYP00000008318 | E3 ubiquitin-protein ligase MARCHF6; E3 ubiquitin-protein ligase that promotes 'Lys-48'-linked ubiquitination of target proteins, leading to their proteasomal degradation. Promotes ubiquitination of DIO2, leading to its degradation. Promotes ubiquitination of SQLE, leading to its degradation. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May cooperate with UBE2G1. | AMFR isoform 1. | 0.794 |
| MARCHF6 | SYVN1 | ENSPPYP00000017141 | ENSPPYP00000003559 | E3 ubiquitin-protein ligase MARCHF6; E3 ubiquitin-protein ligase that promotes 'Lys-48'-linked ubiquitination of target proteins, leading to their proteasomal degradation. Promotes ubiquitination of DIO2, leading to its degradation. Promotes ubiquitination of SQLE, leading to its degradation. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May cooperate with UBE2G1. | SYVN1 isoform 3. | 0.794 |
| MARCHF6 | UBC | ENSPPYP00000017141 | ENSPPYP00000005811 | E3 ubiquitin-protein ligase MARCHF6; E3 ubiquitin-protein ligase that promotes 'Lys-48'-linked ubiquitination of target proteins, leading to their proteasomal degradation. Promotes ubiquitination of DIO2, leading to its degradation. Promotes ubiquitination of SQLE, leading to its degradation. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May cooperate with UBE2G1. | UBC isoform 2. | 0.560 |
| MARCHF6 | UBE2G2 | ENSPPYP00000017141 | ENSPPYP00000012839 | E3 ubiquitin-protein ligase MARCHF6; E3 ubiquitin-protein ligase that promotes 'Lys-48'-linked ubiquitination of target proteins, leading to their proteasomal degradation. Promotes ubiquitination of DIO2, leading to its degradation. Promotes ubiquitination of SQLE, leading to its degradation. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May cooperate with UBE2G1. | Ubiquitin-conjugating enzyme E2 G2; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'- linked polyubiquitination. Involved in endoplasmic reticulum-associated degradation (ERAD). | 0.935 |
| MARCHF6 | UBE2J2 | ENSPPYP00000017141 | ENSPPYP00000002333 | E3 ubiquitin-protein ligase MARCHF6; E3 ubiquitin-protein ligase that promotes 'Lys-48'-linked ubiquitination of target proteins, leading to their proteasomal degradation. Promotes ubiquitination of DIO2, leading to its degradation. Promotes ubiquitination of SQLE, leading to its degradation. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May cooperate with UBE2G1. | Ubiquitin conjugating enzyme E2 J2. | 0.860 |
| RBX1 | UBA1 | ENSPPYP00000013235 | ENSPPYP00000022706 | RBX1 isoform 1. | UBA1 isoform 1; Belongs to the ubiquitin-activating E1 family. | 0.528 |
| RBX1 | UBA7 | ENSPPYP00000013235 | ENSPPYP00000015508 | RBX1 isoform 1. | UBA7 isoform 1; Belongs to the ubiquitin-activating E1 family. | 0.524 |
| RBX1 | UBC | ENSPPYP00000013235 | ENSPPYP00000005811 | RBX1 isoform 1. | UBC isoform 2. | 0.921 |
| RBX1 | UBE2G1 | ENSPPYP00000013235 | ENSPPYP00000008817 | RBX1 isoform 1. | Ubiquitin conjugating enzyme E2 G1; Belongs to the ubiquitin-conjugating enzyme family. | 0.951 |
| RBX1 | UBE2G2 | ENSPPYP00000013235 | ENSPPYP00000012839 | RBX1 isoform 1. | Ubiquitin-conjugating enzyme E2 G2; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'- linked polyubiquitination. Involved in endoplasmic reticulum-associated degradation (ERAD). | 0.886 |
| RBX1 | UBE2J2 | ENSPPYP00000013235 | ENSPPYP00000002333 | RBX1 isoform 1. | Ubiquitin conjugating enzyme E2 J2. | 0.409 |
