node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CR201_G0053059 | ENSPPYP00000008747 | ENSPPYP00000013535 | ENSPPYP00000008747 | TPR_REGION domain-containing protein. | annotation not available | 0.993 |
CR201_G0053059 | ENSPPYP00000024386 | ENSPPYP00000013535 | ENSPPYP00000024386 | TPR_REGION domain-containing protein. | E3 SUMO-protein ligase RanBP2. | 0.865 |
CR201_G0053059 | SAE1 | ENSPPYP00000013535 | ENSPPYP00000011372 | TPR_REGION domain-containing protein. | SUMO-activating enzyme subunit 1, N-terminally processed; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2 (By similarity); Belongs to the ubiquitin-activating E1 family. | 0.448 |
CR201_G0053059 | SUMO3 | ENSPPYP00000013535 | ENSPPYP00000012841 | TPR_REGION domain-containing protein. | Small ubiquitin-related modifier. | 0.739 |
CR201_G0053059 | TP53 | ENSPPYP00000013535 | ENSPPYP00000008923 | TPR_REGION domain-containing protein. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.420 |
CR201_G0053059 | UBA2 | ENSPPYP00000013535 | ENSPPYP00000011014 | TPR_REGION domain-containing protein. | SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family. | 0.413 |
CR201_G0053059 | UBE2I | ENSPPYP00000013535 | ENSPPYP00000007864 | TPR_REGION domain-containing protein. | Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. | 0.991 |
ENSPPYP00000008747 | CR201_G0053059 | ENSPPYP00000008747 | ENSPPYP00000013535 | annotation not available | TPR_REGION domain-containing protein. | 0.993 |
ENSPPYP00000008747 | ENSPPYP00000024386 | ENSPPYP00000008747 | ENSPPYP00000024386 | annotation not available | E3 SUMO-protein ligase RanBP2. | 0.993 |
ENSPPYP00000008747 | SUMO3 | ENSPPYP00000008747 | ENSPPYP00000012841 | annotation not available | Small ubiquitin-related modifier. | 0.754 |
ENSPPYP00000008747 | UBE2I | ENSPPYP00000008747 | ENSPPYP00000007864 | annotation not available | Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. | 0.922 |
ENSPPYP00000024386 | CR201_G0053059 | ENSPPYP00000024386 | ENSPPYP00000013535 | E3 SUMO-protein ligase RanBP2. | TPR_REGION domain-containing protein. | 0.865 |
ENSPPYP00000024386 | ENSPPYP00000008747 | ENSPPYP00000024386 | ENSPPYP00000008747 | E3 SUMO-protein ligase RanBP2. | annotation not available | 0.993 |
ENSPPYP00000024386 | SAE1 | ENSPPYP00000024386 | ENSPPYP00000011372 | E3 SUMO-protein ligase RanBP2. | SUMO-activating enzyme subunit 1, N-terminally processed; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2 (By similarity); Belongs to the ubiquitin-activating E1 family. | 0.448 |
ENSPPYP00000024386 | SUMO3 | ENSPPYP00000024386 | ENSPPYP00000012841 | E3 SUMO-protein ligase RanBP2. | Small ubiquitin-related modifier. | 0.972 |
ENSPPYP00000024386 | TP53 | ENSPPYP00000024386 | ENSPPYP00000008923 | E3 SUMO-protein ligase RanBP2. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.420 |
ENSPPYP00000024386 | UBA2 | ENSPPYP00000024386 | ENSPPYP00000011014 | E3 SUMO-protein ligase RanBP2. | SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family. | 0.413 |
ENSPPYP00000024386 | UBE2I | ENSPPYP00000024386 | ENSPPYP00000007864 | E3 SUMO-protein ligase RanBP2. | Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. | 0.999 |
PCNA | PIAS4 | ENSPPYP00000012059 | ENSPPYP00000010535 | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | PIAS4 isoform 1. | 0.564 |
PCNA | SUMO3 | ENSPPYP00000012059 | ENSPPYP00000012841 | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | Small ubiquitin-related modifier. | 0.756 |