STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
BIDBID isoform 12. (99 aa)    
Predicted Functional Partners:
BCL2
BCL2 isoform 1.
   
 0.988
BAK1
Bcl-2 homologous antagonist/killer.
   
 0.987
CR201_G0016264
BAK1 isoform 3.
   
 0.987
MCL1
MCL1 apoptosis regulator, BCL2 family member.
   
 0.953
BCL2L1
BCL2L1 isoform 2.
   
 0.952
BCL2A1
BCL2A1 isoform 1.
   
 0.923
CASP8
CASP8 isoform 1; Belongs to the peptidase C14A family.
   
 0.838
CR201_G0029582
BAX isoform 2.
   
 0.830
CASP10
CASP10 isoform 3; Belongs to the peptidase C14A family.
   
 0.725
FADD
FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.
   
 
 0.716
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.