| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| COX18 | TANGO2 | ENSPPYP00000016549 | ENSPPYP00000012929 | Cytochrome c oxidase assembly protein COX18, mitochondrial; Mitochondrial membrane insertase required for the translocation of the C-terminus of cytochrome c oxidase subunit II (MT- CO2/COX2) across the mitochondrial inner membrane. Plays a role in MT- CO2/COX2 maturation following the COX20-mediated stabilization of newly synthesized MT-CO2/COX2 protein and before the action of the metallochaperones SCO1/2. Essential for the assembly and stability of the mitochondrial respiratory chain complex IV (also known as cytochrome c oxidase). | Transport and golgi organization 2 homolog. | 0.529 |
| COX18 | TIMM21 | ENSPPYP00000016549 | ENSPPYP00000010367 | Cytochrome c oxidase assembly protein COX18, mitochondrial; Mitochondrial membrane insertase required for the translocation of the C-terminus of cytochrome c oxidase subunit II (MT- CO2/COX2) across the mitochondrial inner membrane. Plays a role in MT- CO2/COX2 maturation following the COX20-mediated stabilization of newly synthesized MT-CO2/COX2 protein and before the action of the metallochaperones SCO1/2. Essential for the assembly and stability of the mitochondrial respiratory chain complex IV (also known as cytochrome c oxidase). | Mitochondrial import inner membrane translocase subunit Tim21; Participates in the translocation of transit peptide- containing proteins across the mitochondrial inner membrane. Also required for assembly of mitochondrial respiratory chain complex I and complex IV as component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex. Probably shuttles between the presequence translocase and respiratory-chain assembly intermediates in a process that promotes incorporation of early nuclear-encoded subunits into these complexes. | 0.506 |
| COX18 | TOMM22 | ENSPPYP00000016549 | ENSPPYP00000013190 | Cytochrome c oxidase assembly protein COX18, mitochondrial; Mitochondrial membrane insertase required for the translocation of the C-terminus of cytochrome c oxidase subunit II (MT- CO2/COX2) across the mitochondrial inner membrane. Plays a role in MT- CO2/COX2 maturation following the COX20-mediated stabilization of newly synthesized MT-CO2/COX2 protein and before the action of the metallochaperones SCO1/2. Essential for the assembly and stability of the mitochondrial respiratory chain complex IV (also known as cytochrome c oxidase). | Translocase of outer mitochondrial membrane 22. | 0.570 |
| COX18 | TRMO | ENSPPYP00000016549 | ENSPPYP00000021772 | Cytochrome c oxidase assembly protein COX18, mitochondrial; Mitochondrial membrane insertase required for the translocation of the C-terminus of cytochrome c oxidase subunit II (MT- CO2/COX2) across the mitochondrial inner membrane. Plays a role in MT- CO2/COX2 maturation following the COX20-mediated stabilization of newly synthesized MT-CO2/COX2 protein and before the action of the metallochaperones SCO1/2. Essential for the assembly and stability of the mitochondrial respiratory chain complex IV (also known as cytochrome c oxidase). | TRMO isoform 1. | 0.594 |
| COX18 | USP25 | ENSPPYP00000016549 | ENSPPYP00000012612 | Cytochrome c oxidase assembly protein COX18, mitochondrial; Mitochondrial membrane insertase required for the translocation of the C-terminus of cytochrome c oxidase subunit II (MT- CO2/COX2) across the mitochondrial inner membrane. Plays a role in MT- CO2/COX2 maturation following the COX20-mediated stabilization of newly synthesized MT-CO2/COX2 protein and before the action of the metallochaperones SCO1/2. Essential for the assembly and stability of the mitochondrial respiratory chain complex IV (also known as cytochrome c oxidase). | USP25 isoform 2; Belongs to the peptidase C19 family. | 0.487 |
| COX18 | USP36 | ENSPPYP00000016549 | ENSPPYP00000009761 | Cytochrome c oxidase assembly protein COX18, mitochondrial; Mitochondrial membrane insertase required for the translocation of the C-terminus of cytochrome c oxidase subunit II (MT- CO2/COX2) across the mitochondrial inner membrane. Plays a role in MT- CO2/COX2 maturation following the COX20-mediated stabilization of newly synthesized MT-CO2/COX2 protein and before the action of the metallochaperones SCO1/2. Essential for the assembly and stability of the mitochondrial respiratory chain complex IV (also known as cytochrome c oxidase). | Ubiquitin specific peptidase 36; Belongs to the peptidase C19 family. | 0.491 |
| MRPL40 | TANGO2 | ENSPPYP00000012915 | ENSPPYP00000012929 | MRPL40 isoform 1. | Transport and golgi organization 2 homolog. | 0.614 |
| MRPL40 | TXNRD2 | ENSPPYP00000012915 | ENSPPYP00000012925 | MRPL40 isoform 1. | Thioredoxin reductase 2. | 0.480 |
| PPM1F | TANGO2 | ENSPPYP00000023899 | ENSPPYP00000012929 | PPM1F isoform 4. | Transport and golgi organization 2 homolog. | 0.607 |
| TANGO2 | COX18 | ENSPPYP00000012929 | ENSPPYP00000016549 | Transport and golgi organization 2 homolog. | Cytochrome c oxidase assembly protein COX18, mitochondrial; Mitochondrial membrane insertase required for the translocation of the C-terminus of cytochrome c oxidase subunit II (MT- CO2/COX2) across the mitochondrial inner membrane. Plays a role in MT- CO2/COX2 maturation following the COX20-mediated stabilization of newly synthesized MT-CO2/COX2 protein and before the action of the metallochaperones SCO1/2. Essential for the assembly and stability of the mitochondrial respiratory chain complex IV (also known as cytochrome c oxidase). | 0.529 |
| TANGO2 | MRPL40 | ENSPPYP00000012929 | ENSPPYP00000012915 | Transport and golgi organization 2 homolog. | MRPL40 isoform 1. | 0.614 |
| TANGO2 | PPM1F | ENSPPYP00000012929 | ENSPPYP00000023899 | Transport and golgi organization 2 homolog. | PPM1F isoform 4. | 0.607 |
| TANGO2 | TIMM21 | ENSPPYP00000012929 | ENSPPYP00000010367 | Transport and golgi organization 2 homolog. | Mitochondrial import inner membrane translocase subunit Tim21; Participates in the translocation of transit peptide- containing proteins across the mitochondrial inner membrane. Also required for assembly of mitochondrial respiratory chain complex I and complex IV as component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex. Probably shuttles between the presequence translocase and respiratory-chain assembly intermediates in a process that promotes incorporation of early nuclear-encoded subunits into these complexes. | 0.625 |
| TANGO2 | TOMM22 | ENSPPYP00000012929 | ENSPPYP00000013190 | Transport and golgi organization 2 homolog. | Translocase of outer mitochondrial membrane 22. | 0.524 |
| TANGO2 | TRMO | ENSPPYP00000012929 | ENSPPYP00000021772 | Transport and golgi organization 2 homolog. | TRMO isoform 1. | 0.614 |
| TANGO2 | TXNRD2 | ENSPPYP00000012929 | ENSPPYP00000012925 | Transport and golgi organization 2 homolog. | Thioredoxin reductase 2. | 0.524 |
| TANGO2 | USP25 | ENSPPYP00000012929 | ENSPPYP00000012612 | Transport and golgi organization 2 homolog. | USP25 isoform 2; Belongs to the peptidase C19 family. | 0.537 |
| TANGO2 | USP36 | ENSPPYP00000012929 | ENSPPYP00000009761 | Transport and golgi organization 2 homolog. | Ubiquitin specific peptidase 36; Belongs to the peptidase C19 family. | 0.532 |
| TANGO2 | ZDHHC8 | ENSPPYP00000012929 | ENSPPYP00000012933 | Transport and golgi organization 2 homolog. | Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. | 0.526 |
| TIMM21 | COX18 | ENSPPYP00000010367 | ENSPPYP00000016549 | Mitochondrial import inner membrane translocase subunit Tim21; Participates in the translocation of transit peptide- containing proteins across the mitochondrial inner membrane. Also required for assembly of mitochondrial respiratory chain complex I and complex IV as component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex. Probably shuttles between the presequence translocase and respiratory-chain assembly intermediates in a process that promotes incorporation of early nuclear-encoded subunits into these complexes. | Cytochrome c oxidase assembly protein COX18, mitochondrial; Mitochondrial membrane insertase required for the translocation of the C-terminus of cytochrome c oxidase subunit II (MT- CO2/COX2) across the mitochondrial inner membrane. Plays a role in MT- CO2/COX2 maturation following the COX20-mediated stabilization of newly synthesized MT-CO2/COX2 protein and before the action of the metallochaperones SCO1/2. Essential for the assembly and stability of the mitochondrial respiratory chain complex IV (also known as cytochrome c oxidase). | 0.506 |
