XBP1 protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATF6	ATF6B	ENSPPYP00000000688	ENSPPYP00000018428	Activating transcription factor 6.	ATF6B isoform 2.	0.956
ATF6	DDIT3	ENSPPYP00000000688	ENSPPYP00000005345	Activating transcription factor 6.	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...]	0.985
ATF6	EDEM1	ENSPPYP00000000688	ENSPPYP00000015312	Activating transcription factor 6.	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	0.636
ATF6	ERN1	ENSPPYP00000000688	ENSPPYP00000009594	Activating transcription factor 6.	ERN1 isoform 1.	0.762
ATF6	HSPA5	ENSPPYP00000000688	ENSPPYP00000021973	Activating transcription factor 6.	Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to dis [...]	0.998
ATF6	XBP1	ENSPPYP00000000688	ENSPPYP00000013025	Activating transcription factor 6.	X-box binding protein 1.	0.948
ATF6B	ATF6	ENSPPYP00000018428	ENSPPYP00000000688	ATF6B isoform 2.	Activating transcription factor 6.	0.956
ATF6B	DDIT3	ENSPPYP00000018428	ENSPPYP00000005345	ATF6B isoform 2.	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...]	0.965
ATF6B	EDEM1	ENSPPYP00000018428	ENSPPYP00000015312	ATF6B isoform 2.	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	0.496
ATF6B	ERN1	ENSPPYP00000018428	ENSPPYP00000009594	ATF6B isoform 2.	ERN1 isoform 1.	0.511
ATF6B	HSPA5	ENSPPYP00000018428	ENSPPYP00000021973	ATF6B isoform 2.	Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to dis [...]	0.944
ATF6B	XBP1	ENSPPYP00000018428	ENSPPYP00000013025	ATF6B isoform 2.	X-box binding protein 1.	0.819
DDIT3	ATF6	ENSPPYP00000005345	ENSPPYP00000000688	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...]	Activating transcription factor 6.	0.985
DDIT3	ATF6B	ENSPPYP00000005345	ENSPPYP00000018428	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...]	ATF6B isoform 2.	0.965
DDIT3	ERN1	ENSPPYP00000005345	ENSPPYP00000009594	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...]	ERN1 isoform 1.	0.633
DDIT3	HSPA5	ENSPPYP00000005345	ENSPPYP00000021973	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...]	Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to dis [...]	0.684
DDIT3	XBP1	ENSPPYP00000005345	ENSPPYP00000013025	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...]	X-box binding protein 1.	0.964
EDEM1	ATF6	ENSPPYP00000015312	ENSPPYP00000000688	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	Activating transcription factor 6.	0.636
EDEM1	ATF6B	ENSPPYP00000015312	ENSPPYP00000018428	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	ATF6B isoform 2.	0.496
EDEM1	ERN1	ENSPPYP00000015312	ENSPPYP00000009594	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	ERN1 isoform 1.	0.595