CR201_G0024554 protein (Pongo abelii) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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Knowledge-based Evidence

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gene co-occurrence

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Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C12orf66	CR201_G0024554	ENSPPYP00000005382	ENSPPYP00000013096	C12orf66 isoform 1.	DEPDC5 isoform 11.	0.983
C12orf66	ITFG2	ENSPPYP00000005382	ENSPPYP00000004733	C12orf66 isoform 1.	KICSTOR complex protein ITFG2; As part of the KICSTOR complex functions in the amino acid- sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose.	0.998
C12orf66	KPTN	ENSPPYP00000005382	ENSPPYP00000011380	C12orf66 isoform 1.	KPTN isoform 1.	0.996
C12orf66	MIOS	ENSPPYP00000005382	ENSPPYP00000019940	C12orf66 isoform 1.	GATOR complex protein MIOS; As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex. It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1.	0.809
C12orf66	NPRL2	ENSPPYP00000005382	ENSPPYP00000015488	C12orf66 isoform 1.	NPR2 like, GATOR1 complex subunit.	0.975
C12orf66	NPRL3	ENSPPYP00000005382	ENSPPYP00000007809	C12orf66 isoform 1.	NPRL3 isoform 6.	0.877
C12orf66	RRAGA	ENSPPYP00000005382	ENSPPYP00000021503	C12orf66 isoform 1.	Ras related GTP binding A.	0.603
C12orf66	RRAGC	ENSPPYP00000005382	ENSPPYP00000001752	C12orf66 isoform 1.	RRAGC isoform 1.	0.611
C12orf66	WDR24	ENSPPYP00000005382	ENSPPYP00000007839	C12orf66 isoform 1.	WDR24 isoform 1.	0.991
C12orf66	WDR59	ENSPPYP00000005382	ENSPPYP00000008526	C12orf66 isoform 1.	WDR59 isoform 2.	0.978
CR201_G0024554	C12orf66	ENSPPYP00000013096	ENSPPYP00000005382	DEPDC5 isoform 11.	C12orf66 isoform 1.	0.983
CR201_G0024554	ITFG2	ENSPPYP00000013096	ENSPPYP00000004733	DEPDC5 isoform 11.	KICSTOR complex protein ITFG2; As part of the KICSTOR complex functions in the amino acid- sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose.	0.976
CR201_G0024554	KPTN	ENSPPYP00000013096	ENSPPYP00000011380	DEPDC5 isoform 11.	KPTN isoform 1.	0.970
CR201_G0024554	MIOS	ENSPPYP00000013096	ENSPPYP00000019940	DEPDC5 isoform 11.	GATOR complex protein MIOS; As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex. It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1.	0.993
CR201_G0024554	NPRL2	ENSPPYP00000013096	ENSPPYP00000015488	DEPDC5 isoform 11.	NPR2 like, GATOR1 complex subunit.	0.997
CR201_G0024554	NPRL3	ENSPPYP00000013096	ENSPPYP00000007809	DEPDC5 isoform 11.	NPRL3 isoform 6.	0.998
CR201_G0024554	RRAGA	ENSPPYP00000013096	ENSPPYP00000021503	DEPDC5 isoform 11.	Ras related GTP binding A.	0.980
CR201_G0024554	RRAGC	ENSPPYP00000013096	ENSPPYP00000001752	DEPDC5 isoform 11.	RRAGC isoform 1.	0.974
CR201_G0024554	WDR24	ENSPPYP00000013096	ENSPPYP00000007839	DEPDC5 isoform 11.	WDR24 isoform 1.	0.992
CR201_G0024554	WDR59	ENSPPYP00000013096	ENSPPYP00000008526	DEPDC5 isoform 11.	WDR59 isoform 2.	0.990