| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BMP6 | HAMP | ENSPPYP00000018132 | ENSPPYP00000011035 | BMP6 isoform 1. | Hepcidin; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By similarity); Belongs to the hepcidin family. | 0.634 |
| BMP6 | HFE | ENSPPYP00000018132 | ENSPPYP00000018234 | BMP6 isoform 1. | Homeostatic iron regulator; Belongs to the MHC class I family. | 0.531 |
| BMP6 | HJV | ENSPPYP00000018132 | ENSPPYP00000001079 | BMP6 isoform 1. | HFE2 isoform 3. | 0.724 |
| BMP6 | TFR2 | ENSPPYP00000018132 | ENSPPYP00000019526 | BMP6 isoform 1. | TFR2 isoform 2. | 0.509 |
| BMP6 | TMPRSS6 | ENSPPYP00000018132 | ENSPPYP00000013149 | BMP6 isoform 1. | TMPRSS6 isoform 2; Belongs to the peptidase S1 family. | 0.564 |
| BOP1 | TMPRSS6 | ENSPPYP00000024742 | ENSPPYP00000013149 | Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. | TMPRSS6 isoform 2; Belongs to the peptidase S1 family. | 0.652 |
| DCN | TMPRSS6 | ENSPPYP00000005504 | ENSPPYP00000013149 | Decorin; May affect the rate of fibrils formation. | TMPRSS6 isoform 2; Belongs to the peptidase S1 family. | 0.822 |
| HAMP | BMP6 | ENSPPYP00000011035 | ENSPPYP00000018132 | Hepcidin; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By similarity); Belongs to the hepcidin family. | BMP6 isoform 1. | 0.634 |
| HAMP | HFE | ENSPPYP00000011035 | ENSPPYP00000018234 | Hepcidin; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By similarity); Belongs to the hepcidin family. | Homeostatic iron regulator; Belongs to the MHC class I family. | 0.737 |
| HAMP | HJV | ENSPPYP00000011035 | ENSPPYP00000001079 | Hepcidin; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By similarity); Belongs to the hepcidin family. | HFE2 isoform 3. | 0.762 |
| HAMP | SLC11A2 | ENSPPYP00000011035 | ENSPPYP00000024385 | Hepcidin; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By similarity); Belongs to the hepcidin family. | SLC11A2 isoform 12. | 0.773 |
| HAMP | TFR2 | ENSPPYP00000011035 | ENSPPYP00000019526 | Hepcidin; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By similarity); Belongs to the hepcidin family. | TFR2 isoform 2. | 0.721 |
| HAMP | TFRC | ENSPPYP00000011035 | ENSPPYP00000016144 | Hepcidin; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By similarity); Belongs to the hepcidin family. | Transferrin receptor protein 1; Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Positively regulates T and B cell proliferation through iron uptake (By similarity). | 0.718 |
| HAMP | TMPRSS6 | ENSPPYP00000011035 | ENSPPYP00000013149 | Hepcidin; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By similarity); Belongs to the hepcidin family. | TMPRSS6 isoform 2; Belongs to the peptidase S1 family. | 0.850 |
| HFE | BMP6 | ENSPPYP00000018234 | ENSPPYP00000018132 | Homeostatic iron regulator; Belongs to the MHC class I family. | BMP6 isoform 1. | 0.531 |
| HFE | HAMP | ENSPPYP00000018234 | ENSPPYP00000011035 | Homeostatic iron regulator; Belongs to the MHC class I family. | Hepcidin; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By similarity); Belongs to the hepcidin family. | 0.737 |
| HFE | HJV | ENSPPYP00000018234 | ENSPPYP00000001079 | Homeostatic iron regulator; Belongs to the MHC class I family. | HFE2 isoform 3. | 0.971 |
| HFE | SLC11A2 | ENSPPYP00000018234 | ENSPPYP00000024385 | Homeostatic iron regulator; Belongs to the MHC class I family. | SLC11A2 isoform 12. | 0.641 |
| HFE | TFR2 | ENSPPYP00000018234 | ENSPPYP00000019526 | Homeostatic iron regulator; Belongs to the MHC class I family. | TFR2 isoform 2. | 0.994 |
| HFE | TFRC | ENSPPYP00000018234 | ENSPPYP00000016144 | Homeostatic iron regulator; Belongs to the MHC class I family. | Transferrin receptor protein 1; Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Positively regulates T and B cell proliferation through iron uptake (By similarity). | 0.999 |
