| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ATF2 | ATF3 | ENSPPYP00000014461 | ENSPPYP00000000244 | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. | Activating transcription factor 3. | 0.794 |
| ATF2 | ATF4 | ENSPPYP00000014461 | ENSPPYP00000013213 | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. | ATF4 isoform 1. | 0.947 |
| ATF2 | ATF6B | ENSPPYP00000014461 | ENSPPYP00000018428 | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. | ATF6B isoform 2. | 0.916 |
| ATF2 | CEBPG | ENSPPYP00000014461 | ENSPPYP00000011005 | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. | CEBPG isoform 1. | 0.807 |
| ATF2 | CREBBP | ENSPPYP00000014461 | ENSPPYP00000007974 | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. | CREBBP isoform 1. | 0.979 |
| ATF2 | DDIT3 | ENSPPYP00000014461 | ENSPPYP00000005345 | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. | DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] | 0.449 |
| ATF2 | EP300 | ENSPPYP00000014461 | ENSPPYP00000013236 | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. | EP300 isoform 1. | 0.944 |
| ATF3 | ATF2 | ENSPPYP00000000244 | ENSPPYP00000014461 | Activating transcription factor 3. | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. | 0.794 |
| ATF3 | ATF4 | ENSPPYP00000000244 | ENSPPYP00000013213 | Activating transcription factor 3. | ATF4 isoform 1. | 0.972 |
| ATF3 | CEBPG | ENSPPYP00000000244 | ENSPPYP00000011005 | Activating transcription factor 3. | CEBPG isoform 1. | 0.801 |
| ATF3 | DDIT3 | ENSPPYP00000000244 | ENSPPYP00000005345 | Activating transcription factor 3. | DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] | 0.969 |
| ATF3 | EIF2S1 | ENSPPYP00000000244 | ENSPPYP00000006729 | Activating transcription factor 3. | Eukaryotic translation initiation factor 2 subunit 1; Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre- initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF- 2 must exchange with GTP by way of a reaction catalyzed [...] | 0.418 |
| ATF3 | TRIB3 | ENSPPYP00000000244 | ENSPPYP00000012140 | Activating transcription factor 3. | TRIB3 isoform 1. | 0.572 |
| ATF4 | ATF2 | ENSPPYP00000013213 | ENSPPYP00000014461 | ATF4 isoform 1. | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. | 0.947 |
| ATF4 | ATF3 | ENSPPYP00000013213 | ENSPPYP00000000244 | ATF4 isoform 1. | Activating transcription factor 3. | 0.972 |
| ATF4 | ATF6B | ENSPPYP00000013213 | ENSPPYP00000018428 | ATF4 isoform 1. | ATF6B isoform 2. | 0.950 |
| ATF4 | CEBPG | ENSPPYP00000013213 | ENSPPYP00000011005 | ATF4 isoform 1. | CEBPG isoform 1. | 0.964 |
| ATF4 | CREBBP | ENSPPYP00000013213 | ENSPPYP00000007974 | ATF4 isoform 1. | CREBBP isoform 1. | 0.983 |
| ATF4 | DDIT3 | ENSPPYP00000013213 | ENSPPYP00000005345 | ATF4 isoform 1. | DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] | 0.994 |
| ATF4 | EIF2S1 | ENSPPYP00000013213 | ENSPPYP00000006729 | ATF4 isoform 1. | Eukaryotic translation initiation factor 2 subunit 1; Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre- initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF- 2 must exchange with GTP by way of a reaction catalyzed [...] | 0.975 |
