ST13 protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPPYP00000005659	ENSPPYP00000017062	ENSPPYP00000005659	ENSPPYP00000017062	annotation not available	annotation not available	0.958
ENSPPYP00000005659	HSP90AA1	ENSPPYP00000005659	ENSPPYP00000006994	annotation not available	HSP90AA1 isoform 6.	0.958
ENSPPYP00000005659	HSPA1A	ENSPPYP00000005659	ENSPPYP00000018408	annotation not available	Heat shock 70 kDa protein 1; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP [...]	0.880
ENSPPYP00000005659	HSPA1L	ENSPPYP00000005659	ENSPPYP00000018406	annotation not available	Heat shock protein family A (Hsp70) member 1 like; Belongs to the heat shock protein 70 family.	0.950
ENSPPYP00000005659	HSPA2	ENSPPYP00000005659	ENSPPYP00000006709	annotation not available	Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family.	0.967
ENSPPYP00000005659	HSPA4	ENSPPYP00000005659	ENSPPYP00000017643	annotation not available	Heat shock 70 kDa protein 4; Belongs to the heat shock protein 70 family.	0.942
ENSPPYP00000005659	HSPA5	ENSPPYP00000005659	ENSPPYP00000021973	annotation not available	Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to dis [...]	0.955
ENSPPYP00000005659	ST13	ENSPPYP00000005659	ENSPPYP00000013232	annotation not available	Hsc70-interacting protein; One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins (By similarity).	0.837
ENSPPYP00000017062	ENSPPYP00000005659	ENSPPYP00000017062	ENSPPYP00000005659	annotation not available	annotation not available	0.958
ENSPPYP00000017062	HSPA1A	ENSPPYP00000017062	ENSPPYP00000018408	annotation not available	Heat shock 70 kDa protein 1; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP [...]	0.756
ENSPPYP00000017062	HSPA1L	ENSPPYP00000017062	ENSPPYP00000018406	annotation not available	Heat shock protein family A (Hsp70) member 1 like; Belongs to the heat shock protein 70 family.	0.756
ENSPPYP00000017062	HSPA2	ENSPPYP00000017062	ENSPPYP00000006709	annotation not available	Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family.	0.887
ENSPPYP00000017062	HSPA4	ENSPPYP00000017062	ENSPPYP00000017643	annotation not available	Heat shock 70 kDa protein 4; Belongs to the heat shock protein 70 family.	0.930
ENSPPYP00000017062	HSPA5	ENSPPYP00000017062	ENSPPYP00000021973	annotation not available	Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to dis [...]	0.738
ENSPPYP00000017062	HSPA8	ENSPPYP00000017062	ENSPPYP00000004564	annotation not available	Heat shock cognate 71 kDa protein; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis a [...]	0.958
ENSPPYP00000017062	ST13	ENSPPYP00000017062	ENSPPYP00000013232	annotation not available	Hsc70-interacting protein; One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins (By similarity).	0.647
HSP90AA1	ENSPPYP00000005659	ENSPPYP00000006994	ENSPPYP00000005659	HSP90AA1 isoform 6.	annotation not available	0.958
HSP90AA1	HSPA1A	ENSPPYP00000006994	ENSPPYP00000018408	HSP90AA1 isoform 6.	Heat shock 70 kDa protein 1; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP [...]	0.756
HSP90AA1	HSPA1L	ENSPPYP00000006994	ENSPPYP00000018406	HSP90AA1 isoform 6.	Heat shock protein family A (Hsp70) member 1 like; Belongs to the heat shock protein 70 family.	0.756
HSP90AA1	HSPA2	ENSPPYP00000006994	ENSPPYP00000006709	HSP90AA1 isoform 6.	Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family.	0.887