| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CBR1 | CBR3 | ENSPPYP00000012724 | ENSPPYP00000012725 | Carbonyl reductase [NADPH] 1; NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2- alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S- nitrosoglutathione (By similarity) [...] | Carbonyl reductase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.997 |
| CBR1 | CR201_G0031908 | ENSPPYP00000012724 | ENSPPYP00000013271 | Carbonyl reductase [NADPH] 1; NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2- alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S- nitrosoglutathione (By similarity) [...] | CYP2D6 isoform 5. | 0.919 |
| CBR1 | CYP2A13 | ENSPPYP00000012724 | ENSPPYP00000011203 | Carbonyl reductase [NADPH] 1; NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2- alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S- nitrosoglutathione (By similarity) [...] | CYP2A13 isoform 1; Belongs to the cytochrome P450 family. | 0.915 |
| CBR1 | CYP3A4 | ENSPPYP00000012724 | ENSPPYP00000019486 | Carbonyl reductase [NADPH] 1; NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2- alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S- nitrosoglutathione (By similarity) [...] | Cytochrome P450 family 3 subfamily A member 4. | 0.918 |
| CBR3 | CBR1 | ENSPPYP00000012725 | ENSPPYP00000012724 | Carbonyl reductase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Carbonyl reductase [NADPH] 1; NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2- alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S- nitrosoglutathione (By similarity) [...] | 0.997 |
| CBR3 | CR201_G0031908 | ENSPPYP00000012725 | ENSPPYP00000013271 | Carbonyl reductase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | CYP2D6 isoform 5. | 0.919 |
| CBR3 | CYP2A13 | ENSPPYP00000012725 | ENSPPYP00000011203 | Carbonyl reductase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | CYP2A13 isoform 1; Belongs to the cytochrome P450 family. | 0.915 |
| CBR3 | CYP3A4 | ENSPPYP00000012725 | ENSPPYP00000019486 | Carbonyl reductase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Cytochrome P450 family 3 subfamily A member 4. | 0.947 |
| CR201_G0031908 | CBR1 | ENSPPYP00000013271 | ENSPPYP00000012724 | CYP2D6 isoform 5. | Carbonyl reductase [NADPH] 1; NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2- alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S- nitrosoglutathione (By similarity) [...] | 0.919 |
| CR201_G0031908 | CBR3 | ENSPPYP00000013271 | ENSPPYP00000012725 | CYP2D6 isoform 5. | Carbonyl reductase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.919 |
| CR201_G0031908 | CYP2A13 | ENSPPYP00000013271 | ENSPPYP00000011203 | CYP2D6 isoform 5. | CYP2A13 isoform 1; Belongs to the cytochrome P450 family. | 0.932 |
| CR201_G0031908 | CYP3A4 | ENSPPYP00000013271 | ENSPPYP00000019486 | CYP2D6 isoform 5. | Cytochrome P450 family 3 subfamily A member 4. | 0.936 |
| CR201_G0031908 | FMO1 | ENSPPYP00000013271 | ENSPPYP00000000596 | CYP2D6 isoform 5. | Dimethylaniline monooxygenase [N-oxide-forming]. | 0.930 |
| CR201_G0031908 | FMO2 | ENSPPYP00000013271 | ENSPPYP00000000598 | CYP2D6 isoform 5. | Dimethylaniline monooxygenase [N-oxide-forming] 2; This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. | 0.924 |
| CR201_G0031908 | FMO3 | ENSPPYP00000013271 | ENSPPYP00000000601 | CYP2D6 isoform 5. | Dimethylaniline monooxygenase [N-oxide-forming]. | 0.920 |
| CR201_G0031908 | FMO4 | ENSPPYP00000013271 | ENSPPYP00000000595 | CYP2D6 isoform 5. | Dimethylaniline monooxygenase [N-oxide-forming]. | 0.930 |
| CR201_G0031908 | MAOA | ENSPPYP00000013271 | ENSPPYP00000022677 | CYP2D6 isoform 5. | Amine oxidase [flavin-containing] A; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine (By similarity). | 0.925 |
| CR201_G0031908 | MAOB | ENSPPYP00000013271 | ENSPPYP00000022680 | CYP2D6 isoform 5. | Amine oxidase [flavin-containing] B; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine (By similarity). | 0.923 |
| CYP2A13 | CBR1 | ENSPPYP00000011203 | ENSPPYP00000012724 | CYP2A13 isoform 1; Belongs to the cytochrome P450 family. | Carbonyl reductase [NADPH] 1; NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2- alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S- nitrosoglutathione (By similarity) [...] | 0.915 |
| CYP2A13 | CBR3 | ENSPPYP00000011203 | ENSPPYP00000012725 | CYP2A13 isoform 1; Belongs to the cytochrome P450 family. | Carbonyl reductase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.915 |
