| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ATF2 | ENSPPYP00000013364 | ENSPPYP00000014461 | ENSPPYP00000013364 | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. | annotation not available | 0.899 |
| ATF2 | MAPK12 | ENSPPYP00000014461 | ENSPPYP00000013363 | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. | Mitogen-activated protein kinase. | 0.967 |
| ATF2 | TP53 | ENSPPYP00000014461 | ENSPPYP00000008923 | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.414 |
| ENSPPYP00000013364 | ATF2 | ENSPPYP00000013364 | ENSPPYP00000014461 | annotation not available | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. | 0.899 |
| ENSPPYP00000013364 | MAP2K6 | ENSPPYP00000013364 | ENSPPYP00000009634 | annotation not available | Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. | 0.839 |
| ENSPPYP00000013364 | MAPK12 | ENSPPYP00000013364 | ENSPPYP00000013363 | annotation not available | Mitogen-activated protein kinase. | 0.885 |
| ENSPPYP00000013364 | MAPKAPK2 | ENSPPYP00000013364 | ENSPPYP00000000301 | annotation not available | MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. | 0.947 |
| ENSPPYP00000013364 | MAPKAPK3 | ENSPPYP00000013364 | ENSPPYP00000015481 | annotation not available | MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. | 0.962 |
| ENSPPYP00000013364 | MAPKAPK5 | ENSPPYP00000013364 | ENSPPYP00000005668 | annotation not available | MAPKAPK5 isoform 3. | 0.836 |
| ENSPPYP00000013364 | MEF2A | ENSPPYP00000013364 | ENSPPYP00000007730 | annotation not available | Myocyte-specific enhancer factor 2A; Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylate [...] | 0.851 |
| ENSPPYP00000013364 | PLA2G4A | ENSPPYP00000013364 | ENSPPYP00000000461 | annotation not available | Cytosolic phospholipase A2; Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response (By similarity). | 0.841 |
| ENSPPYP00000013364 | SYNGR1 | ENSPPYP00000013364 | ENSPPYP00000013210 | annotation not available | Synaptogyrin-1; May play a role in regulated exocytosis. Modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in synaptic-like microvesicle formation and/or maturation (By similarity). Involved in the regulation of short- term and long-term synaptic plasticity (By similarity). Belongs to the synaptogyrin family. | 0.909 |
| ENSPPYP00000013364 | TP53 | ENSPPYP00000013364 | ENSPPYP00000008923 | annotation not available | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.854 |
| MAP2K6 | ENSPPYP00000013364 | ENSPPYP00000009634 | ENSPPYP00000013364 | Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. | annotation not available | 0.839 |
| MAP2K6 | MAPK12 | ENSPPYP00000009634 | ENSPPYP00000013363 | Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. | Mitogen-activated protein kinase. | 0.977 |
| MAP2K6 | MAPKAPK2 | ENSPPYP00000009634 | ENSPPYP00000000301 | Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. | MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. | 0.967 |
| MAP2K6 | MAPKAPK3 | ENSPPYP00000009634 | ENSPPYP00000015481 | Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. | MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. | 0.582 |
| MAP2K6 | MAPKAPK5 | ENSPPYP00000009634 | ENSPPYP00000005668 | Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. | MAPKAPK5 isoform 3. | 0.599 |
| MAP2K6 | SYNGR1 | ENSPPYP00000009634 | ENSPPYP00000013210 | Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. | Synaptogyrin-1; May play a role in regulated exocytosis. Modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in synaptic-like microvesicle formation and/or maturation (By similarity). Involved in the regulation of short- term and long-term synaptic plasticity (By similarity). Belongs to the synaptogyrin family. | 0.964 |
| MAPK12 | ATF2 | ENSPPYP00000013363 | ENSPPYP00000014461 | Mitogen-activated protein kinase. | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. | 0.967 |
