| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CASP1 | IL1A | ENSPPYP00000004375 | ENSPPYP00000013572 | CASP1 isoform 4; Belongs to the peptidase C14A family. | Interleukin-1; Belongs to the IL-1 family. | 0.749 |
| CASP1 | IL1B | ENSPPYP00000004375 | ENSPPYP00000013573 | CASP1 isoform 4; Belongs to the peptidase C14A family. | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | 0.996 |
| CASP1 | IL1R1 | ENSPPYP00000004375 | ENSPPYP00000013505 | CASP1 isoform 4; Belongs to the peptidase C14A family. | Interleukin 1 receptor type 1. | 0.586 |
| CASP1 | NFKB1 | ENSPPYP00000004375 | ENSPPYP00000016712 | CASP1 isoform 4; Belongs to the peptidase C14A family. | Nuclear factor kappa B subunit 1. | 0.575 |
| CASP1 | NLRP3 | ENSPPYP00000004375 | ENSPPYP00000000034 | CASP1 isoform 4; Belongs to the peptidase C14A family. | NLRP3 isoform 2. | 0.951 |
| CASP1 | PYCARD | ENSPPYP00000004375 | ENSPPYP00000008260 | CASP1 isoform 4; Belongs to the peptidase C14A family. | PYD and CARD domain containing. | 0.999 |
| CASP1 | TNF | ENSPPYP00000004375 | ENSPPYP00000018379 | CASP1 isoform 4; Belongs to the peptidase C14A family. | Tumor necrosis factor ligand 1F; Belongs to the tumor necrosis factor family. | 0.699 |
| IL1A | CASP1 | ENSPPYP00000013572 | ENSPPYP00000004375 | Interleukin-1; Belongs to the IL-1 family. | CASP1 isoform 4; Belongs to the peptidase C14A family. | 0.749 |
| IL1A | IL1B | ENSPPYP00000013572 | ENSPPYP00000013573 | Interleukin-1; Belongs to the IL-1 family. | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | 0.999 |
| IL1A | IL1R1 | ENSPPYP00000013572 | ENSPPYP00000013505 | Interleukin-1; Belongs to the IL-1 family. | Interleukin 1 receptor type 1. | 0.966 |
| IL1A | IL1R2 | ENSPPYP00000013572 | ENSPPYP00000013501 | Interleukin-1; Belongs to the IL-1 family. | IL1R2 isoform 2. | 0.994 |
| IL1A | JUN | ENSPPYP00000013572 | ENSPPYP00000001511 | Interleukin-1; Belongs to the IL-1 family. | JUN isoform 1; Belongs to the bZIP family. | 0.695 |
| IL1A | NFKB1 | ENSPPYP00000013572 | ENSPPYP00000016712 | Interleukin-1; Belongs to the IL-1 family. | Nuclear factor kappa B subunit 1. | 0.790 |
| IL1A | NLRP3 | ENSPPYP00000013572 | ENSPPYP00000000034 | Interleukin-1; Belongs to the IL-1 family. | NLRP3 isoform 2. | 0.510 |
| IL1A | PYCARD | ENSPPYP00000013572 | ENSPPYP00000008260 | Interleukin-1; Belongs to the IL-1 family. | PYD and CARD domain containing. | 0.408 |
| IL1A | RELA | ENSPPYP00000013572 | ENSPPYP00000003533 | Interleukin-1; Belongs to the IL-1 family. | RELA proto-oncogene, NF-kB subunit. | 0.632 |
| IL1A | TNF | ENSPPYP00000013572 | ENSPPYP00000018379 | Interleukin-1; Belongs to the IL-1 family. | Tumor necrosis factor ligand 1F; Belongs to the tumor necrosis factor family. | 0.927 |
| IL1B | CASP1 | ENSPPYP00000013573 | ENSPPYP00000004375 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | CASP1 isoform 4; Belongs to the peptidase C14A family. | 0.996 |
| IL1B | IL1A | ENSPPYP00000013573 | ENSPPYP00000013572 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | Interleukin-1; Belongs to the IL-1 family. | 0.999 |
| IL1B | IL1R1 | ENSPPYP00000013573 | ENSPPYP00000013505 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | Interleukin 1 receptor type 1. | 0.970 |
