node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GAK | ITSN2 | ENSPPYP00000016219 | ENSPPYP00000014069 | GAK isoform 7. | ITSN2 isoform 3. | 0.750 |
GAK | VAMP7 | ENSPPYP00000016219 | ENSPPYP00000023405 | GAK isoform 7. | Vesicle-associated membrane protein 7; Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocy [...] | 0.896 |
GAK | VAMP8 | ENSPPYP00000016219 | ENSPPYP00000013635 | GAK isoform 7. | Vesicle-associated membrane protein 8; SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane via its interaction with the STX17-SNAP29 binary t- SNARE complex. Also required for dense-granule secretion in platelets. Plays als [...] | 0.897 |
ITSN2 | GAK | ENSPPYP00000014069 | ENSPPYP00000016219 | ITSN2 isoform 3. | GAK isoform 7. | 0.750 |
ITSN2 | SNAP23 | ENSPPYP00000014069 | ENSPPYP00000007248 | ITSN2 isoform 3. | Synaptosomal-associated protein; Belongs to the SNAP-25 family. | 0.579 |
ITSN2 | SNAP25 | ENSPPYP00000014069 | ENSPPYP00000011970 | ITSN2 isoform 3. | Synaptosomal-associated protein 25; t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells. | 0.625 |
ITSN2 | SNAP29 | ENSPPYP00000014069 | ENSPPYP00000013412 | ITSN2 isoform 3. | Synaptosomal-associated protein 29; SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. SNAP29 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Plays also a role in ciliogenesis by regulating membrane fusions. | 0.568 |
ITSN2 | VAMP7 | ENSPPYP00000014069 | ENSPPYP00000023405 | ITSN2 isoform 3. | Vesicle-associated membrane protein 7; Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocy [...] | 0.920 |
ITSN2 | VAMP8 | ENSPPYP00000014069 | ENSPPYP00000013635 | ITSN2 isoform 3. | Vesicle-associated membrane protein 8; SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane via its interaction with the STX17-SNAP29 binary t- SNARE complex. Also required for dense-granule secretion in platelets. Plays als [...] | 0.921 |
SNAP23 | ITSN2 | ENSPPYP00000007248 | ENSPPYP00000014069 | Synaptosomal-associated protein; Belongs to the SNAP-25 family. | ITSN2 isoform 3. | 0.579 |
SNAP23 | SNAP25 | ENSPPYP00000007248 | ENSPPYP00000011970 | Synaptosomal-associated protein; Belongs to the SNAP-25 family. | Synaptosomal-associated protein 25; t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells. | 0.476 |
SNAP23 | SNAP29 | ENSPPYP00000007248 | ENSPPYP00000013412 | Synaptosomal-associated protein; Belongs to the SNAP-25 family. | Synaptosomal-associated protein 29; SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. SNAP29 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Plays also a role in ciliogenesis by regulating membrane fusions. | 0.807 |
SNAP23 | STX12 | ENSPPYP00000007248 | ENSPPYP00000001911 | Synaptosomal-associated protein; Belongs to the SNAP-25 family. | Syntaxin-12; SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. The SNARE complex containing STX6, STX12, VAMP4 and VTI1A mediates vesicle fusion (in vitro) (By similarity). Through complex formation with GRIP1, GRIA2 and NSG1 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity). | 0.966 |
SNAP23 | STX16 | ENSPPYP00000007248 | ENSPPYP00000012482 | Synaptosomal-associated protein; Belongs to the SNAP-25 family. | STX16-NPEPL1 isoform 1; Belongs to the syntaxin family. | 0.655 |
SNAP23 | STX1A | ENSPPYP00000007248 | ENSPPYP00000019613 | Synaptosomal-associated protein; Belongs to the SNAP-25 family. | Syntaxin-1A; Plays an essential role in hormone and neurotransmitter calcium-dependent exocytosis and endocytosis. Part of the SNARE (Soluble NSF Attachment Receptor) complex composed of SNAP25, STX1A and VAMP2 which mediates the fusion of synaptic vesicles with the presynaptic plasma membrane. STX1A and SNAP25 are localized on the plasma membrane while VAMP2 resides in synaptic vesicles. The pairing of the three SNAREs from the N-terminal SNARE motifs to the C-terminal anchors leads to the formation of the SNARE complex, which brings membranes into close proximity and results in final [...] | 0.997 |
SNAP23 | VAMP7 | ENSPPYP00000007248 | ENSPPYP00000023405 | Synaptosomal-associated protein; Belongs to the SNAP-25 family. | Vesicle-associated membrane protein 7; Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocy [...] | 0.998 |
SNAP23 | VAMP8 | ENSPPYP00000007248 | ENSPPYP00000013635 | Synaptosomal-associated protein; Belongs to the SNAP-25 family. | Vesicle-associated membrane protein 8; SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane via its interaction with the STX17-SNAP29 binary t- SNARE complex. Also required for dense-granule secretion in platelets. Plays als [...] | 0.792 |
SNAP23 | YKT6 | ENSPPYP00000007248 | ENSPPYP00000019721 | Synaptosomal-associated protein; Belongs to the SNAP-25 family. | YKT6 v-SNARE homolog; Belongs to the synaptobrevin family. | 0.486 |
SNAP25 | ITSN2 | ENSPPYP00000011970 | ENSPPYP00000014069 | Synaptosomal-associated protein 25; t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells. | ITSN2 isoform 3. | 0.625 |
SNAP25 | SNAP23 | ENSPPYP00000011970 | ENSPPYP00000007248 | Synaptosomal-associated protein 25; t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells. | Synaptosomal-associated protein; Belongs to the SNAP-25 family. | 0.476 |