GGCX protein (Pongo abelii) - STRING interaction network

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GGCX

Vitamin K-dependent gamma-carboxylase; Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide. (758 aa)

Predicted Functional Partners:

VKORC1

0.981

VKORC1L1

0.930

NQO1

0.927

PROS1

0.919

F7

0.872

F2

0.871

GAS6

0.783

CR201_G0055283

0.700

CR201_G0037528

0.699

PRRG1

0.697

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CR201_G0037528	F7	ENSPPYP00000010844	ENSPPYP00000006292	CYP4F3 isoform 2; Belongs to the cytochrome P450 family.	F7 isoform 3.	0.508
CR201_G0037528	GGCX	ENSPPYP00000010844	ENSPPYP00000013637	CYP4F3 isoform 2; Belongs to the cytochrome P450 family.	Vitamin K-dependent gamma-carboxylase; Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide.	0.699
CR201_G0037528	PROS1	ENSPPYP00000010844	ENSPPYP00000015240	CYP4F3 isoform 2; Belongs to the cytochrome P450 family.	PROS1 isoform 1.	0.456
CR201_G0037528	VKORC1	ENSPPYP00000010844	ENSPPYP00000008254	CYP4F3 isoform 2; Belongs to the cytochrome P450 family.	T0121409 isoform 1.	0.803
CR201_G0055283	GGCX	ENSPPYP00000008067	ENSPPYP00000013637	ABCC6 isoform 1.	Vitamin K-dependent gamma-carboxylase; Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide.	0.700
CR201_G0055283	VKORC1	ENSPPYP00000008067	ENSPPYP00000008254	ABCC6 isoform 1.	T0121409 isoform 1.	0.642
F2	F7	ENSPPYP00000003807	ENSPPYP00000006292	Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity).	F7 isoform 3.	0.858
F2	GGCX	ENSPPYP00000003807	ENSPPYP00000013637	Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity).	Vitamin K-dependent gamma-carboxylase; Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide.	0.871
F2	VKORC1	ENSPPYP00000003807	ENSPPYP00000008254	Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity).	T0121409 isoform 1.	0.655
F7	CR201_G0037528	ENSPPYP00000006292	ENSPPYP00000010844	F7 isoform 3.	CYP4F3 isoform 2; Belongs to the cytochrome P450 family.	0.508
F7	F2	ENSPPYP00000006292	ENSPPYP00000003807	F7 isoform 3.	Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity).	0.858
F7	GGCX	ENSPPYP00000006292	ENSPPYP00000013637	F7 isoform 3.	Vitamin K-dependent gamma-carboxylase; Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide.	0.872
F7	PROS1	ENSPPYP00000006292	ENSPPYP00000015240	F7 isoform 3.	PROS1 isoform 1.	0.413
F7	VKORC1	ENSPPYP00000006292	ENSPPYP00000008254	F7 isoform 3.	T0121409 isoform 1.	0.596
GAS6	GGCX	ENSPPYP00000006305	ENSPPYP00000013637	Growth arrest specific 6.	Vitamin K-dependent gamma-carboxylase; Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide.	0.783
GAS6	PROS1	ENSPPYP00000006305	ENSPPYP00000015240	Growth arrest specific 6.	PROS1 isoform 1.	0.648
GGCX	CR201_G0037528	ENSPPYP00000013637	ENSPPYP00000010844	Vitamin K-dependent gamma-carboxylase; Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide.	CYP4F3 isoform 2; Belongs to the cytochrome P450 family.	0.699
GGCX	CR201_G0055283	ENSPPYP00000013637	ENSPPYP00000008067	Vitamin K-dependent gamma-carboxylase; Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide.	ABCC6 isoform 1.	0.700
GGCX	F2	ENSPPYP00000013637	ENSPPYP00000003807	Vitamin K-dependent gamma-carboxylase; Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide.	Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity).	0.871
GGCX	F7	ENSPPYP00000013637	ENSPPYP00000006292	Vitamin K-dependent gamma-carboxylase; Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide.	F7 isoform 3.	0.872

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