Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of proteins in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| LATS1 | LATS2 | ENSPPYP00000019136 | ENSPPYP00000005920 | Large tumor suppressor kinase 1. | Non-specific serine/threonine protein kinase. | 0.991 |
| LATS1 | MOB1A | ENSPPYP00000019136 | ENSPPYP00000013698 | Large tumor suppressor kinase 1. | MOB kinase activator 1A; Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellu [...] | 0.991 |
| LATS1 | MOB1B | ENSPPYP00000019136 | ENSPPYP00000016542 | Large tumor suppressor kinase 1. | MOB kinase activator 1B. | 0.992 |
| LATS1 | MTUS1 | ENSPPYP00000019136 | ENSPPYP00000020603 | Large tumor suppressor kinase 1. | Microtubule-associated tumor suppressor 1 homolog; Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation (By similarity). | 0.661 |
| LATS1 | SAV1 | ENSPPYP00000019136 | ENSPPYP00000006597 | Large tumor suppressor kinase 1. | Salvador family WW domain containing protein 1. | 0.975 |
| LATS1 | STK3 | ENSPPYP00000019136 | ENSPPYP00000021064 | Large tumor suppressor kinase 1. | STK3 isoform 3. | 0.992 |
| LATS1 | STK4 | ENSPPYP00000019136 | ENSPPYP00000012335 | Large tumor suppressor kinase 1. | STK4 isoform 1. | 0.825 |
| LATS1 | WWTR1 | ENSPPYP00000019136 | ENSPPYP00000015879 | Large tumor suppressor kinase 1. | WW domain containing transcription regulator 1. | 0.996 |
| LATS2 | LATS1 | ENSPPYP00000005920 | ENSPPYP00000019136 | Non-specific serine/threonine protein kinase. | Large tumor suppressor kinase 1. | 0.991 |
| LATS2 | MOB1A | ENSPPYP00000005920 | ENSPPYP00000013698 | Non-specific serine/threonine protein kinase. | MOB kinase activator 1A; Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellu [...] | 0.980 |
| LATS2 | MOB1B | ENSPPYP00000005920 | ENSPPYP00000016542 | Non-specific serine/threonine protein kinase. | MOB kinase activator 1B. | 0.981 |
| LATS2 | MTUS1 | ENSPPYP00000005920 | ENSPPYP00000020603 | Non-specific serine/threonine protein kinase. | Microtubule-associated tumor suppressor 1 homolog; Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation (By similarity). | 0.661 |
| LATS2 | SAV1 | ENSPPYP00000005920 | ENSPPYP00000006597 | Non-specific serine/threonine protein kinase. | Salvador family WW domain containing protein 1. | 0.976 |
| LATS2 | STK3 | ENSPPYP00000005920 | ENSPPYP00000021064 | Non-specific serine/threonine protein kinase. | STK3 isoform 3. | 0.972 |
| LATS2 | STK4 | ENSPPYP00000005920 | ENSPPYP00000012335 | Non-specific serine/threonine protein kinase. | STK4 isoform 1. | 0.898 |
| LATS2 | WWTR1 | ENSPPYP00000005920 | ENSPPYP00000015879 | Non-specific serine/threonine protein kinase. | WW domain containing transcription regulator 1. | 0.986 |
| MOB1A | LATS1 | ENSPPYP00000013698 | ENSPPYP00000019136 | MOB kinase activator 1A; Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellu [...] | Large tumor suppressor kinase 1. | 0.991 |
| MOB1A | LATS2 | ENSPPYP00000013698 | ENSPPYP00000005920 | MOB kinase activator 1A; Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellu [...] | Non-specific serine/threonine protein kinase. | 0.980 |
| MOB1A | MOB1B | ENSPPYP00000013698 | ENSPPYP00000016542 | MOB kinase activator 1A; Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellu [...] | MOB kinase activator 1B. | 0.994 |
| MOB1A | MTUS1 | ENSPPYP00000013698 | ENSPPYP00000020603 | MOB kinase activator 1A; Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellu [...] | Microtubule-associated tumor suppressor 1 homolog; Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation (By similarity). | 0.830 |
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