MOB1A protein (Pongo abelii) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LATS1	LATS2	ENSPPYP00000019136	ENSPPYP00000005920	Large tumor suppressor kinase 1.	Non-specific serine/threonine protein kinase.	0.998
LATS1	MOB1A	ENSPPYP00000019136	ENSPPYP00000013698	Large tumor suppressor kinase 1.	MOB kinase activator 1A; Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellu [...]	0.991
LATS1	MOB1B	ENSPPYP00000019136	ENSPPYP00000016542	Large tumor suppressor kinase 1.	MOB kinase activator 1B.	0.997
LATS1	MTUS1	ENSPPYP00000019136	ENSPPYP00000020603	Large tumor suppressor kinase 1.	Microtubule-associated tumor suppressor 1 homolog; Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation (By similarity).	0.650
LATS1	SAV1	ENSPPYP00000019136	ENSPPYP00000006597	Large tumor suppressor kinase 1.	Salvador family WW domain containing protein 1.	0.983
LATS1	STK3	ENSPPYP00000019136	ENSPPYP00000021064	Large tumor suppressor kinase 1.	STK3 isoform 3.	0.996
LATS1	STK4	ENSPPYP00000019136	ENSPPYP00000012335	Large tumor suppressor kinase 1.	STK4 isoform 1.	0.890
LATS2	LATS1	ENSPPYP00000005920	ENSPPYP00000019136	Non-specific serine/threonine protein kinase.	Large tumor suppressor kinase 1.	0.998
LATS2	MOB1A	ENSPPYP00000005920	ENSPPYP00000013698	Non-specific serine/threonine protein kinase.	MOB kinase activator 1A; Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellu [...]	0.984
LATS2	MOB1B	ENSPPYP00000005920	ENSPPYP00000016542	Non-specific serine/threonine protein kinase.	MOB kinase activator 1B.	0.996
LATS2	MTUS1	ENSPPYP00000005920	ENSPPYP00000020603	Non-specific serine/threonine protein kinase.	Microtubule-associated tumor suppressor 1 homolog; Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation (By similarity).	0.650
LATS2	SAV1	ENSPPYP00000005920	ENSPPYP00000006597	Non-specific serine/threonine protein kinase.	Salvador family WW domain containing protein 1.	0.984
LATS2	STK3	ENSPPYP00000005920	ENSPPYP00000021064	Non-specific serine/threonine protein kinase.	STK3 isoform 3.	0.989
LATS2	STK4	ENSPPYP00000005920	ENSPPYP00000012335	Non-specific serine/threonine protein kinase.	STK4 isoform 1.	0.919
MOB1A	LATS1	ENSPPYP00000013698	ENSPPYP00000019136	MOB kinase activator 1A; Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellu [...]	Large tumor suppressor kinase 1.	0.991
MOB1A	LATS2	ENSPPYP00000013698	ENSPPYP00000005920	MOB kinase activator 1A; Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellu [...]	Non-specific serine/threonine protein kinase.	0.984
MOB1A	MOB1B	ENSPPYP00000013698	ENSPPYP00000016542	MOB kinase activator 1A; Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellu [...]	MOB kinase activator 1B.	0.999
MOB1A	MTUS1	ENSPPYP00000013698	ENSPPYP00000020603	MOB kinase activator 1A; Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellu [...]	Microtubule-associated tumor suppressor 1 homolog; Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation (By similarity).	0.749
MOB1A	PJA2	ENSPPYP00000013698	ENSPPYP00000017525	MOB kinase activator 1A; Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellu [...]	E3 ubiquitin-protein ligase Praja-2; Has E2-dependent E3 ubiquitin-protein ligase activity. Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA-mediated long-term memory processes. Through the ubiquitination of MFHAS1, positively regulates the TLR2 signaling pathway that leads to the activation of the downstream p38 and JNK MAP kinases and promotes the polarization of macrophages toward the pro-inflammatory M1 phenotype.	0.776
MOB1A	SAV1	ENSPPYP00000013698	ENSPPYP00000006597	MOB kinase activator 1A; Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellu [...]	Salvador family WW domain containing protein 1.	0.956