SIX2 protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

SIX2

SIX homeobox 2. (291 aa)

Predicted Functional Partners:

EYA1

0.813

EYA2

0.779

EYA3

0.697

SALL1

0.681

PAX2

0.578

WNT9B

0.518

EYA4

0.503

WT1

0.503

LHX1

0.498

MYOG

0.483

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EYA1	EYA2	ENSPPYP00000020937	ENSPPYP00000012403	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.400
EYA1	EYA3	ENSPPYP00000020937	ENSPPYP00000001904	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.405
EYA1	EYA4	ENSPPYP00000020937	ENSPPYP00000019059	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.426
EYA1	LHX1	ENSPPYP00000020937	ENSPPYP00000009230	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	LHX1 isoform 1.	0.411
EYA1	MYOG	ENSPPYP00000020937	ENSPPYP00000000374	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	MYOG isoform 1.	0.483
EYA1	PAX2	ENSPPYP00000020937	ENSPPYP00000002985	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	PAX2 isoform 3.	0.674
EYA1	SALL1	ENSPPYP00000020937	ENSPPYP00000008295	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	SALL1 isoform 2.	0.652
EYA1	SIX2	ENSPPYP00000020937	ENSPPYP00000013900	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	SIX homeobox 2.	0.813
EYA2	EYA1	ENSPPYP00000012403	ENSPPYP00000020937	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.400
EYA2	EYA3	ENSPPYP00000012403	ENSPPYP00000001904	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.517
EYA2	EYA4	ENSPPYP00000012403	ENSPPYP00000019059	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.404
EYA2	MYOG	ENSPPYP00000012403	ENSPPYP00000000374	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	MYOG isoform 1.	0.574
EYA2	SIX2	ENSPPYP00000012403	ENSPPYP00000013900	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	SIX homeobox 2.	0.779
EYA3	EYA1	ENSPPYP00000001904	ENSPPYP00000020937	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.405
EYA3	EYA2	ENSPPYP00000001904	ENSPPYP00000012403	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.517
EYA3	EYA4	ENSPPYP00000001904	ENSPPYP00000019059	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.403
EYA3	SIX2	ENSPPYP00000001904	ENSPPYP00000013900	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	SIX homeobox 2.	0.697
EYA4	EYA1	ENSPPYP00000019059	ENSPPYP00000020937	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.426
EYA4	EYA2	ENSPPYP00000019059	ENSPPYP00000012403	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.404
EYA4	EYA3	ENSPPYP00000019059	ENSPPYP00000001904	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.403