| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CAMKMT | DOT1L | ENSPPYP00000013903 | ENSPPYP00000010482 | CAMKMT isoform 1. | Histone-lysine N-methyltransferase, H3 lysine-79 specific. | 0.751 |
| CAMKMT | EHMT2 | ENSPPYP00000013903 | ENSPPYP00000018412 | CAMKMT isoform 1. | EHMT2 isoform 5. | 0.759 |
| CAMKMT | PLOD1 | ENSPPYP00000013903 | ENSPPYP00000002169 | CAMKMT isoform 1. | Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1; Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linkling of collagen fibrils (By similarity). Forms hydroxylysine residues in -Xaa-Lys- Gly- sequences in collagens (By similarity). These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links (By similarity). | 0.900 |
| CAMKMT | PLOD2 | ENSPPYP00000013903 | ENSPPYP00000023968 | CAMKMT isoform 1. | PLOD2 isoform 2. | 0.900 |
| CAMKMT | PLOD3 | ENSPPYP00000013903 | ENSPPYP00000019555 | CAMKMT isoform 1. | Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3; Multifunctional enzyme that catalyzes a series of post- translational modifications on Lys residues in procollagen. Plays a redundant role in catalyzing the formation of hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens (By similarity). Plays a redundant role in catalyzing the transfer of galactose onto hydroxylysine groups, giving rise to galactosyl 5-hydroxylysine (By similarity). Has an essential role by catalyzing the subsequent transfer of glucose moieties, giving rise to 1,2-glucosylgalactosy [...] | 0.900 |
| CAMKMT | PREPL | ENSPPYP00000013903 | ENSPPYP00000013906 | CAMKMT isoform 1. | Prolyl endopeptidase-like; Serine peptidase whose precise substrate specificity remains unclear (By similarity). Does not cleave peptides after a arginine or lysine residue (By similarity). Regulates trans-Golgi network morphology and sorting by regulating the membrane binding of the AP-1 complex (By similarity). May play a role in the regulation of synaptic vesicle exocytosis (By similarity). | 0.729 |
| CAMKMT | SETD7 | ENSPPYP00000013903 | ENSPPYP00000016839 | CAMKMT isoform 1. | Histone-lysine N-methyltransferase SETD7; Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes. | 0.746 |
| CAMKMT | SETDB1 | ENSPPYP00000013903 | ENSPPYP00000001036 | CAMKMT isoform 1. | SETDB1 isoform 4. | 0.738 |
| CAMKMT | SMYD2 | ENSPPYP00000013903 | ENSPPYP00000000230 | CAMKMT isoform 1. | SMYD2 isoform 1. | 0.747 |
| CAMKMT | SUV39H1 | ENSPPYP00000013903 | ENSPPYP00000022743 | CAMKMT isoform 1. | Histone-lysine N-methyltransferase SUV39H1; Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric re [...] | 0.746 |
| DOT1L | CAMKMT | ENSPPYP00000010482 | ENSPPYP00000013903 | Histone-lysine N-methyltransferase, H3 lysine-79 specific. | CAMKMT isoform 1. | 0.751 |
| DOT1L | EHMT2 | ENSPPYP00000010482 | ENSPPYP00000018412 | Histone-lysine N-methyltransferase, H3 lysine-79 specific. | EHMT2 isoform 5. | 0.469 |
| DOT1L | PLOD1 | ENSPPYP00000010482 | ENSPPYP00000002169 | Histone-lysine N-methyltransferase, H3 lysine-79 specific. | Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1; Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linkling of collagen fibrils (By similarity). Forms hydroxylysine residues in -Xaa-Lys- Gly- sequences in collagens (By similarity). These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links (By similarity). | 0.650 |
| DOT1L | PLOD2 | ENSPPYP00000010482 | ENSPPYP00000023968 | Histone-lysine N-methyltransferase, H3 lysine-79 specific. | PLOD2 isoform 2. | 0.650 |
| DOT1L | PLOD3 | ENSPPYP00000010482 | ENSPPYP00000019555 | Histone-lysine N-methyltransferase, H3 lysine-79 specific. | Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3; Multifunctional enzyme that catalyzes a series of post- translational modifications on Lys residues in procollagen. Plays a redundant role in catalyzing the formation of hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens (By similarity). Plays a redundant role in catalyzing the transfer of galactose onto hydroxylysine groups, giving rise to galactosyl 5-hydroxylysine (By similarity). Has an essential role by catalyzing the subsequent transfer of glucose moieties, giving rise to 1,2-glucosylgalactosy [...] | 0.650 |
| DOT1L | SETD7 | ENSPPYP00000010482 | ENSPPYP00000016839 | Histone-lysine N-methyltransferase, H3 lysine-79 specific. | Histone-lysine N-methyltransferase SETD7; Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes. | 0.449 |
| DOT1L | SMYD2 | ENSPPYP00000010482 | ENSPPYP00000000230 | Histone-lysine N-methyltransferase, H3 lysine-79 specific. | SMYD2 isoform 1. | 0.457 |
| DOT1L | SUV39H1 | ENSPPYP00000010482 | ENSPPYP00000022743 | Histone-lysine N-methyltransferase, H3 lysine-79 specific. | Histone-lysine N-methyltransferase SUV39H1; Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric re [...] | 0.468 |
| EHMT2 | CAMKMT | ENSPPYP00000018412 | ENSPPYP00000013903 | EHMT2 isoform 5. | CAMKMT isoform 1. | 0.759 |
| EHMT2 | DOT1L | ENSPPYP00000018412 | ENSPPYP00000010482 | EHMT2 isoform 5. | Histone-lysine N-methyltransferase, H3 lysine-79 specific. | 0.469 |
