| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADSS1 | ADSS2 | ENSPPYP00000007034 | ENSPPYP00000000054 | Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | 0.901 |
| ADSS1 | ASS1 | ENSPPYP00000007034 | ENSPPYP00000022070 | Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | ASS1 isoform 1. | 0.930 |
| ADSS1 | CAD | ENSPPYP00000007034 | ENSPPYP00000014025 | Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. | 0.942 |
| ADSS1 | DHODH | ENSPPYP00000007034 | ENSPPYP00000008492 | Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | Dihydroorotate dehydrogenase (quinone), mitochondrial; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. | 0.478 |
| ADSS1 | PPAT | ENSPPYP00000007034 | ENSPPYP00000023924 | Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | Amidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.655 |
| ADSS2 | ADSS1 | ENSPPYP00000000054 | ENSPPYP00000007034 | Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | 0.901 |
| ADSS2 | ASS1 | ENSPPYP00000000054 | ENSPPYP00000022070 | Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | ASS1 isoform 1. | 0.930 |
| ADSS2 | CAD | ENSPPYP00000000054 | ENSPPYP00000014025 | Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. | 0.942 |
| ADSS2 | DHODH | ENSPPYP00000000054 | ENSPPYP00000008492 | Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | Dihydroorotate dehydrogenase (quinone), mitochondrial; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. | 0.478 |
| ADSS2 | PPAT | ENSPPYP00000000054 | ENSPPYP00000023924 | Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | Amidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.705 |
| ASS1 | ADSS1 | ENSPPYP00000022070 | ENSPPYP00000007034 | ASS1 isoform 1. | Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | 0.930 |
| ASS1 | ADSS2 | ENSPPYP00000022070 | ENSPPYP00000000054 | ASS1 isoform 1. | Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | 0.930 |
| ASS1 | CAD | ENSPPYP00000022070 | ENSPPYP00000014025 | ASS1 isoform 1. | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. | 0.971 |
| ASS1 | OTC | ENSPPYP00000022070 | ENSPPYP00000022656 | ASS1 isoform 1. | Ornithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. | 0.992 |
| CAD | ADSS1 | ENSPPYP00000014025 | ENSPPYP00000007034 | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. | Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | 0.942 |
| CAD | ADSS2 | ENSPPYP00000014025 | ENSPPYP00000000054 | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. | Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | 0.942 |
| CAD | ASS1 | ENSPPYP00000014025 | ENSPPYP00000022070 | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. | ASS1 isoform 1. | 0.971 |
| CAD | DHODH | ENSPPYP00000014025 | ENSPPYP00000008492 | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. | Dihydroorotate dehydrogenase (quinone), mitochondrial; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. | 0.984 |
| CAD | GFPT1 | ENSPPYP00000014025 | ENSPPYP00000013761 | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. | GFPT1 isoform 1. | 0.925 |
| CAD | GFPT2 | ENSPPYP00000014025 | ENSPPYP00000018051 | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. | GFPT2 isoform 1. | 0.925 |
