Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
NCOA1Nuclear receptor coactivator. (1293 aa)    
Predicted Functional Partners:
NCOA2
Nuclear receptor coactivator.
  
0.992
ESR1
Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.
    
 0.986
EP300
EP300 isoform 1.
   
 0.984
CREBBP
CREBBP isoform 1.
   
 0.983
NCOA3
Nuclear receptor coactivator.
   
0.982
ESR2
ESR2 isoform 12.
    
 0.980
RXRA
RXRA isoform 2.
   
 0.969
PGR
PGR isoform 1.
    
 0.968
KAT2B
Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily.
   
 0.965
JUN
JUN isoform 1; Belongs to the bZIP family.
    
 0.938
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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