| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CR201_G0024533 | LIMK1 | ENSPPYP00000013085 | ENSPPYP00000019606 | LIMK2 isoform 3. | LIMK1 isoform 2. | 0.994 |
| CR201_G0024533 | RHOA | ENSPPYP00000013085 | ENSPPYP00000015522 | LIMK2 isoform 3. | Transforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...] | 0.459 |
| CR201_G0024533 | ROCK1 | ENSPPYP00000013085 | ENSPPYP00000010161 | LIMK2 isoform 3. | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. | 0.966 |
| CR201_G0024533 | ROCK2 | ENSPPYP00000013085 | ENSPPYP00000014119 | LIMK2 isoform 3. | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. | 0.953 |
| CTNNB1 | RHOA | ENSPPYP00000015644 | ENSPPYP00000015522 | CTNNB1 isoform 2. | Transforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...] | 0.651 |
| CTNNB1 | ROCK1 | ENSPPYP00000015644 | ENSPPYP00000010161 | CTNNB1 isoform 2. | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. | 0.951 |
| CTNNB1 | ROCK2 | ENSPPYP00000015644 | ENSPPYP00000014119 | CTNNB1 isoform 2. | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. | 0.948 |
| LIMK1 | CR201_G0024533 | ENSPPYP00000019606 | ENSPPYP00000013085 | LIMK1 isoform 2. | LIMK2 isoform 3. | 0.994 |
| LIMK1 | RHOA | ENSPPYP00000019606 | ENSPPYP00000015522 | LIMK1 isoform 2. | Transforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...] | 0.628 |
| LIMK1 | ROCK1 | ENSPPYP00000019606 | ENSPPYP00000010161 | LIMK1 isoform 2. | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. | 0.955 |
| LIMK1 | ROCK2 | ENSPPYP00000019606 | ENSPPYP00000014119 | LIMK1 isoform 2. | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. | 0.956 |
| MYL12B | MYL2 | ENSPPYP00000010135 | ENSPPYP00000005656 | Myosin light chain 12B. | MYL2 isoform 2. | 0.930 |
| MYL12B | MYL9 | ENSPPYP00000010135 | ENSPPYP00000012253 | Myosin light chain 12B. | Myosin regulatory light polypeptide 9; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion. | 0.997 |
| MYL12B | PPP1R12A | ENSPPYP00000010135 | ENSPPYP00000005469 | Myosin light chain 12B. | Protein phosphatase 1 regulatory subunit. | 0.961 |
| MYL12B | PPP1R12B | ENSPPYP00000010135 | ENSPPYP00000000384 | Myosin light chain 12B. | Protein phosphatase 1 regulatory subunit. | 0.810 |
| MYL12B | RHOA | ENSPPYP00000010135 | ENSPPYP00000015522 | Myosin light chain 12B. | Transforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...] | 0.569 |
| MYL12B | ROCK1 | ENSPPYP00000010135 | ENSPPYP00000010161 | Myosin light chain 12B. | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. | 0.953 |
| MYL12B | ROCK2 | ENSPPYP00000010135 | ENSPPYP00000014119 | Myosin light chain 12B. | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. | 0.951 |
| MYL2 | MYL12B | ENSPPYP00000005656 | ENSPPYP00000010135 | MYL2 isoform 2. | Myosin light chain 12B. | 0.930 |
| MYL2 | MYL9 | ENSPPYP00000005656 | ENSPPYP00000012253 | MYL2 isoform 2. | Myosin regulatory light polypeptide 9; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion. | 0.930 |
