node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CR201_G0028793 | GRHL1 | ENSPPYP00000007772 | ENSPPYP00000014134 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | Grainyhead-like protein 1 homolog; Transcription factor involved in epithelial development. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3'. Important regulator of DSG1 in the context of hair anchorage and epidermal differentiation, participates in the maintenance of the skin barrier. There is no genetic interaction with GRHL3, no functional cooperativity due to diverse target gene selectivity during epithelia development. Belongs to the grh/CP2 family. Grainyhead subfamily. | 0.458 |
ENSPPYP00000012819 | GLIS2 | ENSPPYP00000012819 | ENSPPYP00000007980 | annotation not available | GLIS family zinc finger 2. | 0.542 |
ENSPPYP00000012819 | GRHL1 | ENSPPYP00000012819 | ENSPPYP00000014134 | annotation not available | Grainyhead-like protein 1 homolog; Transcription factor involved in epithelial development. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3'. Important regulator of DSG1 in the context of hair anchorage and epidermal differentiation, participates in the maintenance of the skin barrier. There is no genetic interaction with GRHL3, no functional cooperativity due to diverse target gene selectivity during epithelia development. Belongs to the grh/CP2 family. Grainyhead subfamily. | 0.498 |
ESRP1 | GRHL1 | ENSPPYP00000021034 | ENSPPYP00000014134 | ESRP1 isoform 2. | Grainyhead-like protein 1 homolog; Transcription factor involved in epithelial development. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3'. Important regulator of DSG1 in the context of hair anchorage and epidermal differentiation, participates in the maintenance of the skin barrier. There is no genetic interaction with GRHL3, no functional cooperativity due to diverse target gene selectivity during epithelia development. Belongs to the grh/CP2 family. Grainyhead subfamily. | 0.499 |
GLIS2 | ENSPPYP00000012819 | ENSPPYP00000007980 | ENSPPYP00000012819 | GLIS family zinc finger 2. | annotation not available | 0.542 |
GLIS2 | GRHL1 | ENSPPYP00000007980 | ENSPPYP00000014134 | GLIS family zinc finger 2. | Grainyhead-like protein 1 homolog; Transcription factor involved in epithelial development. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3'. Important regulator of DSG1 in the context of hair anchorage and epidermal differentiation, participates in the maintenance of the skin barrier. There is no genetic interaction with GRHL3, no functional cooperativity due to diverse target gene selectivity during epithelia development. Belongs to the grh/CP2 family. Grainyhead subfamily. | 0.550 |
GRHL1 | CR201_G0028793 | ENSPPYP00000014134 | ENSPPYP00000007772 | Grainyhead-like protein 1 homolog; Transcription factor involved in epithelial development. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3'. Important regulator of DSG1 in the context of hair anchorage and epidermal differentiation, participates in the maintenance of the skin barrier. There is no genetic interaction with GRHL3, no functional cooperativity due to diverse target gene selectivity during epithelia development. Belongs to the grh/CP2 family. Grainyhead subfamily. | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | 0.458 |
GRHL1 | ENSPPYP00000012819 | ENSPPYP00000014134 | ENSPPYP00000012819 | Grainyhead-like protein 1 homolog; Transcription factor involved in epithelial development. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3'. Important regulator of DSG1 in the context of hair anchorage and epidermal differentiation, participates in the maintenance of the skin barrier. There is no genetic interaction with GRHL3, no functional cooperativity due to diverse target gene selectivity during epithelia development. Belongs to the grh/CP2 family. Grainyhead subfamily. | annotation not available | 0.498 |
GRHL1 | ESRP1 | ENSPPYP00000014134 | ENSPPYP00000021034 | Grainyhead-like protein 1 homolog; Transcription factor involved in epithelial development. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3'. Important regulator of DSG1 in the context of hair anchorage and epidermal differentiation, participates in the maintenance of the skin barrier. There is no genetic interaction with GRHL3, no functional cooperativity due to diverse target gene selectivity during epithelia development. Belongs to the grh/CP2 family. Grainyhead subfamily. | ESRP1 isoform 2. | 0.499 |
GRHL1 | GLIS2 | ENSPPYP00000014134 | ENSPPYP00000007980 | Grainyhead-like protein 1 homolog; Transcription factor involved in epithelial development. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3'. Important regulator of DSG1 in the context of hair anchorage and epidermal differentiation, participates in the maintenance of the skin barrier. There is no genetic interaction with GRHL3, no functional cooperativity due to diverse target gene selectivity during epithelia development. Belongs to the grh/CP2 family. Grainyhead subfamily. | GLIS family zinc finger 2. | 0.550 |
GRHL1 | HSPA12A | ENSPPYP00000014134 | ENSPPYP00000003135 | Grainyhead-like protein 1 homolog; Transcription factor involved in epithelial development. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3'. Important regulator of DSG1 in the context of hair anchorage and epidermal differentiation, participates in the maintenance of the skin barrier. There is no genetic interaction with GRHL3, no functional cooperativity due to diverse target gene selectivity during epithelia development. Belongs to the grh/CP2 family. Grainyhead subfamily. | HSPA12A isoform 1. | 0.456 |
GRHL1 | IKZF2 | ENSPPYP00000014134 | ENSPPYP00000014682 | Grainyhead-like protein 1 homolog; Transcription factor involved in epithelial development. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3'. Important regulator of DSG1 in the context of hair anchorage and epidermal differentiation, participates in the maintenance of the skin barrier. There is no genetic interaction with GRHL3, no functional cooperativity due to diverse target gene selectivity during epithelia development. Belongs to the grh/CP2 family. Grainyhead subfamily. | IKZF2 isoform 3. | 0.425 |
GRHL1 | KLF11 | ENSPPYP00000014134 | ENSPPYP00000014132 | Grainyhead-like protein 1 homolog; Transcription factor involved in epithelial development. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3'. Important regulator of DSG1 in the context of hair anchorage and epidermal differentiation, participates in the maintenance of the skin barrier. There is no genetic interaction with GRHL3, no functional cooperativity due to diverse target gene selectivity during epithelia development. Belongs to the grh/CP2 family. Grainyhead subfamily. | Kruppel like factor 11. | 0.478 |
GRHL1 | MBOAT1 | ENSPPYP00000014134 | ENSPPYP00000018192 | Grainyhead-like protein 1 homolog; Transcription factor involved in epithelial development. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3'. Important regulator of DSG1 in the context of hair anchorage and epidermal differentiation, participates in the maintenance of the skin barrier. There is no genetic interaction with GRHL3, no functional cooperativity due to diverse target gene selectivity during epithelia development. Belongs to the grh/CP2 family. Grainyhead subfamily. | Membrane bound O-acyltransferase domain containing 1; Belongs to the membrane-bound acyltransferase family. | 0.497 |
GRHL1 | SHTN1 | ENSPPYP00000014134 | ENSPPYP00000003137 | Grainyhead-like protein 1 homolog; Transcription factor involved in epithelial development. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3'. Important regulator of DSG1 in the context of hair anchorage and epidermal differentiation, participates in the maintenance of the skin barrier. There is no genetic interaction with GRHL3, no functional cooperativity due to diverse target gene selectivity during epithelia development. Belongs to the grh/CP2 family. Grainyhead subfamily. | Shootin-1; Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1- dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth. Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone. Pl [...] | 0.440 |
HSPA12A | GRHL1 | ENSPPYP00000003135 | ENSPPYP00000014134 | HSPA12A isoform 1. | Grainyhead-like protein 1 homolog; Transcription factor involved in epithelial development. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3'. Important regulator of DSG1 in the context of hair anchorage and epidermal differentiation, participates in the maintenance of the skin barrier. There is no genetic interaction with GRHL3, no functional cooperativity due to diverse target gene selectivity during epithelia development. Belongs to the grh/CP2 family. Grainyhead subfamily. | 0.456 |
HSPA12A | IKZF2 | ENSPPYP00000003135 | ENSPPYP00000014682 | HSPA12A isoform 1. | IKZF2 isoform 3. | 0.431 |
HSPA12A | KLF11 | ENSPPYP00000003135 | ENSPPYP00000014132 | HSPA12A isoform 1. | Kruppel like factor 11. | 0.436 |
HSPA12A | MBOAT1 | ENSPPYP00000003135 | ENSPPYP00000018192 | HSPA12A isoform 1. | Membrane bound O-acyltransferase domain containing 1; Belongs to the membrane-bound acyltransferase family. | 0.685 |
HSPA12A | SHTN1 | ENSPPYP00000003135 | ENSPPYP00000003137 | HSPA12A isoform 1. | Shootin-1; Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1- dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth. Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone. Pl [...] | 0.746 |