| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DR1 | ENY2 | ENSPPYP00000001327 | ENSPPYP00000023516 | Down-regulator of transcription 1. | Transcription and mRNA export factor ENY2; Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for trans [...] | 0.529 |
| DR1 | MBIP | ENSPPYP00000001327 | ENSPPYP00000006532 | Down-regulator of transcription 1. | MBIP isoform 1. | 0.992 |
| DR1 | SUPT3H | ENSPPYP00000001327 | ENSPPYP00000018640 | Down-regulator of transcription 1. | SPT3 homolog, SAGA and STAGA complex component. | 0.605 |
| DR1 | TADA3 | ENSPPYP00000001327 | ENSPPYP00000015293 | Down-regulator of transcription 1. | Transcriptional adapter 3; Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex. Also known as a coactivator for p53/TP53- dependent transcriptional activation (By similarity). Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (By similarity). | 0.991 |
| DR1 | TAF10 | ENSPPYP00000001327 | ENSPPYP00000004055 | Down-regulator of transcription 1. | Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. | 0.576 |
| DR1 | TAF12 | ENSPPYP00000001327 | ENSPPYP00000001889 | Down-regulator of transcription 1. | TAF12 isoform 2. | 0.629 |
| DR1 | TAF1B | ENSPPYP00000001327 | ENSPPYP00000014136 | Down-regulator of transcription 1. | TAF1B isoform 1. | 0.773 |
| DR1 | TAF6 | ENSPPYP00000001327 | ENSPPYP00000019499 | Down-regulator of transcription 1. | TAF6 isoform 4. | 0.447 |
| DR1 | TAF9B | ENSPPYP00000001327 | ENSPPYP00000022945 | Down-regulator of transcription 1. | Transcription initiation factor TFIID subunit 9B; Essential for cell viability. TAF9 and TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. May have a role in gene regulation associated with apoptosis. TAFs are components of the transcription factor IID (TFIID) complex, the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TFIID or TFTC are essential for the regulation of RNA polymerase II-mediated transcription (By similarity). | 0.524 |
| DR1 | TRRAP | ENSPPYP00000001327 | ENSPPYP00000019457 | Down-regulator of transcription 1. | Transformation/transcription domain associated protein; Belongs to the PI3/PI4-kinase family. | 0.582 |
| ENY2 | DR1 | ENSPPYP00000023516 | ENSPPYP00000001327 | Transcription and mRNA export factor ENY2; Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for trans [...] | Down-regulator of transcription 1. | 0.529 |
| ENY2 | MBIP | ENSPPYP00000023516 | ENSPPYP00000006532 | Transcription and mRNA export factor ENY2; Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for trans [...] | MBIP isoform 1. | 0.478 |
| ENY2 | SUPT3H | ENSPPYP00000023516 | ENSPPYP00000018640 | Transcription and mRNA export factor ENY2; Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for trans [...] | SPT3 homolog, SAGA and STAGA complex component. | 0.945 |
| ENY2 | TADA3 | ENSPPYP00000023516 | ENSPPYP00000015293 | Transcription and mRNA export factor ENY2; Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for trans [...] | Transcriptional adapter 3; Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex. Also known as a coactivator for p53/TP53- dependent transcriptional activation (By similarity). Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (By similarity). | 0.951 |
| ENY2 | TAF10 | ENSPPYP00000023516 | ENSPPYP00000004055 | Transcription and mRNA export factor ENY2; Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for trans [...] | Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. | 0.952 |
| ENY2 | TAF12 | ENSPPYP00000023516 | ENSPPYP00000001889 | Transcription and mRNA export factor ENY2; Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for trans [...] | TAF12 isoform 2. | 0.953 |
| ENY2 | TAF1B | ENSPPYP00000023516 | ENSPPYP00000014136 | Transcription and mRNA export factor ENY2; Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for trans [...] | TAF1B isoform 1. | 0.826 |
| ENY2 | TAF6 | ENSPPYP00000023516 | ENSPPYP00000019499 | Transcription and mRNA export factor ENY2; Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for trans [...] | TAF6 isoform 4. | 0.930 |
| ENY2 | TAF9B | ENSPPYP00000023516 | ENSPPYP00000022945 | Transcription and mRNA export factor ENY2; Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for trans [...] | Transcription initiation factor TFIID subunit 9B; Essential for cell viability. TAF9 and TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. May have a role in gene regulation associated with apoptosis. TAFs are components of the transcription factor IID (TFIID) complex, the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TFIID or TFTC are essential for the regulation of RNA polymerase II-mediated transcription (By similarity). | 0.943 |
| ENY2 | TRRAP | ENSPPYP00000023516 | ENSPPYP00000019457 | Transcription and mRNA export factor ENY2; Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for trans [...] | Transformation/transcription domain associated protein; Belongs to the PI3/PI4-kinase family. | 0.950 |
