MAP3K2 protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Edges represent protein-protein associations

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co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

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Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MAP2K3	MAP2K6	ENSPPYP00000009080	ENSPPYP00000009634	Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily.	0.997
MAP2K3	MAP3K2	ENSPPYP00000009080	ENSPPYP00000014245	Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily.	MAP3K2 isoform 1.	0.923
MAP2K3	MAP3K3	ENSPPYP00000009080	ENSPPYP00000009577	Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase kinase kinase 3.	0.935
MAP2K3	TRAF6	ENSPPYP00000009080	ENSPPYP00000003845	Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.656
MAP2K5	MAP3K2	ENSPPYP00000007469	ENSPPYP00000014245	MAP2K5 isoform 1; Belongs to the protein kinase superfamily.	MAP3K2 isoform 1.	0.987
MAP2K5	MAP3K3	ENSPPYP00000007469	ENSPPYP00000009577	MAP2K5 isoform 1; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase kinase kinase 3.	0.993
MAP2K5	SQSTM1	ENSPPYP00000007469	ENSPPYP00000018045	MAP2K5 isoform 1; Belongs to the protein kinase superfamily.	Sequestosome-1; Autophagy receptor required for selective macroautophagy (aggrephagy). Functions as a bridge between polyubiquitinated cargo and autophagosomes. Interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. Required both for the formation and autophagic degradation of polyubiquitin- containing bodies, called ALIS (aggresome-like induced structures) and links ALIS to the autophagic machinery. Involved in midbody ring degradation (By similarity). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and [...]	0.786
MAP2K5	SRC	ENSPPYP00000007469	ENSPPYP00000012270	MAP2K5 isoform 1; Belongs to the protein kinase superfamily.	Tyrosine-protein kinase.	0.404
MAP2K6	MAP2K3	ENSPPYP00000009634	ENSPPYP00000009080	Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily.	0.997
MAP2K6	MAP3K2	ENSPPYP00000009634	ENSPPYP00000014245	Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily.	MAP3K2 isoform 1.	0.920
MAP2K6	MAP3K3	ENSPPYP00000009634	ENSPPYP00000009577	Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase kinase kinase 3.	0.924
MAP2K6	TRAF6	ENSPPYP00000009634	ENSPPYP00000003845	Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.660
MAP3K2	MAP2K3	ENSPPYP00000014245	ENSPPYP00000009080	MAP3K2 isoform 1.	Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily.	0.923
MAP3K2	MAP2K5	ENSPPYP00000014245	ENSPPYP00000007469	MAP3K2 isoform 1.	MAP2K5 isoform 1; Belongs to the protein kinase superfamily.	0.987
MAP3K2	MAP2K6	ENSPPYP00000014245	ENSPPYP00000009634	MAP3K2 isoform 1.	Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily.	0.920
MAP3K2	MAP3K3	ENSPPYP00000014245	ENSPPYP00000009577	MAP3K2 isoform 1.	Mitogen-activated protein kinase kinase kinase 3.	0.958
MAP3K2	PAK1	ENSPPYP00000014245	ENSPPYP00000004237	MAP3K2 isoform 1.	Non-specific serine/threonine protein kinase.	0.932
MAP3K2	PAK2	ENSPPYP00000014245	ENSPPYP00000016156	MAP3K2 isoform 1.	Non-specific serine/threonine protein kinase.	0.932
MAP3K2	SMYD3	ENSPPYP00000014245	ENSPPYP00000000044	MAP3K2 isoform 1.	SMYD3 isoform 2.	0.949
MAP3K2	SQSTM1	ENSPPYP00000014245	ENSPPYP00000018045	MAP3K2 isoform 1.	Sequestosome-1; Autophagy receptor required for selective macroautophagy (aggrephagy). Functions as a bridge between polyubiquitinated cargo and autophagosomes. Interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. Required both for the formation and autophagic degradation of polyubiquitin- containing bodies, called ALIS (aggresome-like induced structures) and links ALIS to the autophagic machinery. Involved in midbody ring degradation (By similarity). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and [...]	0.850