| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CCDC22 | CCDC93 | ENSPPYP00000022770 | ENSPPYP00000014278 | CCDC22 isoform 1. | Coiled-coil domain containing 93. | 0.974 |
| CCDC22 | COMMD2 | ENSPPYP00000022770 | ENSPPYP00000015880 | CCDC22 isoform 1. | COMM domain-containing protein 2; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF-kappa-B. | 0.983 |
| CCDC22 | COMMD5 | ENSPPYP00000022770 | ENSPPYP00000021301 | CCDC22 isoform 1. | COMM domain containing 5. | 0.982 |
| CCDC22 | COMMD8 | ENSPPYP00000022770 | ENSPPYP00000016432 | CCDC22 isoform 1. | COMM domain containing 8. | 0.983 |
| CCDC22 | COMMD9 | ENSPPYP00000022770 | ENSPPYP00000003848 | CCDC22 isoform 1. | COMM domain containing 9. | 0.983 |
| CCDC22 | CR201_G0003257 | ENSPPYP00000022770 | ENSPPYP00000013806 | CCDC22 isoform 1. | COMMD1 isoform 4. | 0.983 |
| CCDC22 | CR201_G0007515 | ENSPPYP00000022770 | ENSPPYP00000006172 | CCDC22 isoform 1. | COMMD6 isoform 1. | 0.981 |
| CCDC22 | VPS26C | ENSPPYP00000022770 | ENSPPYP00000012737 | CCDC22 isoform 1. | Vacuolar protein sorting-associated protein 26C; Acts as component of the retriever complex. The retriever complex is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos such as integrin alpha-5/beta-1 (ITGA5:ITGB1). The recruitment of the retriever complex to the endosomal membrane involves CCC and WASH complexes. In the endosomes, drives the retriever and recycling of NxxY-motif-containing cargo proteins by coupling to SNX17, a cargo essential for the homeostatic maintenance of nu [...] | 0.969 |
| CCDC22 | VPS29 | ENSPPYP00000022770 | ENSPPYP00000005648 | CCDC22 isoform 1. | Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans- Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for carg [...] | 0.961 |
| CCDC22 | VPS35L | ENSPPYP00000022770 | ENSPPYP00000008083 | CCDC22 isoform 1. | VPS35 endosomal protein sorting factor-like; Acts as component of the retriever complex. The retriever complex is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos such as integrin alpha-5/beta-1 (ITGA5:ITGB1). The recruitment of the retriever complex to the endosomal membrane involves CCC and WASH complexes. In the endosomes, drives the retrieval and recycling of NxxY-motif-containing cargo proteins by coupling to SNX17, a cargo essential for the homeostatic maintenance of numero [...] | 0.976 |
| CCDC93 | CCDC22 | ENSPPYP00000014278 | ENSPPYP00000022770 | Coiled-coil domain containing 93. | CCDC22 isoform 1. | 0.974 |
| CCDC93 | COMMD2 | ENSPPYP00000014278 | ENSPPYP00000015880 | Coiled-coil domain containing 93. | COMM domain-containing protein 2; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF-kappa-B. | 0.966 |
| CCDC93 | COMMD5 | ENSPPYP00000014278 | ENSPPYP00000021301 | Coiled-coil domain containing 93. | COMM domain containing 5. | 0.966 |
| CCDC93 | COMMD8 | ENSPPYP00000014278 | ENSPPYP00000016432 | Coiled-coil domain containing 93. | COMM domain containing 8. | 0.966 |
| CCDC93 | COMMD9 | ENSPPYP00000014278 | ENSPPYP00000003848 | Coiled-coil domain containing 93. | COMM domain containing 9. | 0.963 |
| CCDC93 | CR201_G0003257 | ENSPPYP00000014278 | ENSPPYP00000013806 | Coiled-coil domain containing 93. | COMMD1 isoform 4. | 0.967 |
| CCDC93 | CR201_G0007515 | ENSPPYP00000014278 | ENSPPYP00000006172 | Coiled-coil domain containing 93. | COMMD6 isoform 1. | 0.964 |
| CCDC93 | VPS26C | ENSPPYP00000014278 | ENSPPYP00000012737 | Coiled-coil domain containing 93. | Vacuolar protein sorting-associated protein 26C; Acts as component of the retriever complex. The retriever complex is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos such as integrin alpha-5/beta-1 (ITGA5:ITGB1). The recruitment of the retriever complex to the endosomal membrane involves CCC and WASH complexes. In the endosomes, drives the retriever and recycling of NxxY-motif-containing cargo proteins by coupling to SNX17, a cargo essential for the homeostatic maintenance of nu [...] | 0.967 |
| CCDC93 | VPS29 | ENSPPYP00000014278 | ENSPPYP00000005648 | Coiled-coil domain containing 93. | Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans- Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for carg [...] | 0.962 |
| CCDC93 | VPS35L | ENSPPYP00000014278 | ENSPPYP00000008083 | Coiled-coil domain containing 93. | VPS35 endosomal protein sorting factor-like; Acts as component of the retriever complex. The retriever complex is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos such as integrin alpha-5/beta-1 (ITGA5:ITGB1). The recruitment of the retriever complex to the endosomal membrane involves CCC and WASH complexes. In the endosomes, drives the retrieval and recycling of NxxY-motif-containing cargo proteins by coupling to SNX17, a cargo essential for the homeostatic maintenance of numero [...] | 0.969 |
