| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACKR3 | ARRB1 | ENSPPYP00000014880 | ENSPPYP00000004214 | Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. | ARRB1 isoform 2. | 0.658 |
| ACKR3 | CXCL12 | ENSPPYP00000014880 | ENSPPYP00000002594 | Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. | CXCL12 isoform 2; Belongs to the intercrine alpha (chemokine CxC) family. | 0.997 |
| ACKR3 | CXCR4 | ENSPPYP00000014880 | ENSPPYP00000014311 | Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. | C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. | 0.993 |
| ARRB1 | ACKR3 | ENSPPYP00000004214 | ENSPPYP00000014880 | ARRB1 isoform 2. | Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. | 0.658 |
| ARRB1 | CXCR4 | ENSPPYP00000004214 | ENSPPYP00000014311 | ARRB1 isoform 2. | C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. | 0.936 |
| ARRB1 | GNB1 | ENSPPYP00000004214 | ENSPPYP00000002307 | ARRB1 isoform 2. | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | 0.817 |
| ARRB1 | GNB2 | ENSPPYP00000004214 | ENSPPYP00000019528 | ARRB1 isoform 2. | GNB2 isoform 1. | 0.487 |
| ARRB1 | GNB3 | ENSPPYP00000004214 | ENSPPYP00000004790 | ARRB1 isoform 2. | G protein subunit beta 3. | 0.519 |
| CXCL12 | ACKR3 | ENSPPYP00000002594 | ENSPPYP00000014880 | CXCL12 isoform 2; Belongs to the intercrine alpha (chemokine CxC) family. | Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. | 0.997 |
| CXCL12 | CXCR4 | ENSPPYP00000002594 | ENSPPYP00000014311 | CXCL12 isoform 2; Belongs to the intercrine alpha (chemokine CxC) family. | C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. | 0.999 |
| CXCL12 | GNAI2 | ENSPPYP00000002594 | ENSPPYP00000015499 | CXCL12 isoform 2; Belongs to the intercrine alpha (chemokine CxC) family. | GNAI2 isoform 1. | 0.510 |
| CXCL12 | GNAI3 | ENSPPYP00000002594 | ENSPPYP00000001241 | CXCL12 isoform 2; Belongs to the intercrine alpha (chemokine CxC) family. | Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...] | 0.493 |
| CXCL12 | GNB1 | ENSPPYP00000002594 | ENSPPYP00000002307 | CXCL12 isoform 2; Belongs to the intercrine alpha (chemokine CxC) family. | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | 0.568 |
| CXCL12 | GNB2 | ENSPPYP00000002594 | ENSPPYP00000019528 | CXCL12 isoform 2; Belongs to the intercrine alpha (chemokine CxC) family. | GNB2 isoform 1. | 0.564 |
| CXCL12 | GNB3 | ENSPPYP00000002594 | ENSPPYP00000004790 | CXCL12 isoform 2; Belongs to the intercrine alpha (chemokine CxC) family. | G protein subunit beta 3. | 0.447 |
| CXCL12 | GNB5 | ENSPPYP00000002594 | ENSPPYP00000007348 | CXCL12 isoform 2; Belongs to the intercrine alpha (chemokine CxC) family. | Guanine nucleotide-binding protein subunit beta-5; Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (Probable). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (By similarity). May play an important role in neuronal signaling, incl [...] | 0.418 |
| CXCL12 | GNG4 | ENSPPYP00000002594 | ENSPPYP00000000094 | CXCL12 isoform 2; Belongs to the intercrine alpha (chemokine CxC) family. | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | 0.696 |
| CXCR4 | ACKR3 | ENSPPYP00000014311 | ENSPPYP00000014880 | C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. | Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. | 0.993 |
| CXCR4 | ARRB1 | ENSPPYP00000014311 | ENSPPYP00000004214 | C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. | ARRB1 isoform 2. | 0.936 |
| CXCR4 | CXCL12 | ENSPPYP00000014311 | ENSPPYP00000002594 | C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. | CXCL12 isoform 2; Belongs to the intercrine alpha (chemokine CxC) family. | 0.999 |
