| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CUL3 | GLI1 | ENSPPYP00000014786 | ENSPPYP00000005342 | CUL3 isoform 1; Belongs to the cullin family. | GLI family zinc finger 1. | 0.956 |
| CUL3 | GLI2 | ENSPPYP00000014786 | ENSPPYP00000014260 | CUL3 isoform 1; Belongs to the cullin family. | GLI2 isoform 1. | 0.968 |
| CUL3 | GLI3 | ENSPPYP00000014786 | ENSPPYP00000019741 | CUL3 isoform 1; Belongs to the cullin family. | GLI3 isoform 3. | 0.961 |
| CUL3 | RBX1 | ENSPPYP00000014786 | ENSPPYP00000013235 | CUL3 isoform 1; Belongs to the cullin family. | RBX1 isoform 1. | 0.998 |
| CUL3 | SPOP | ENSPPYP00000014786 | ENSPPYP00000010012 | CUL3 isoform 1; Belongs to the cullin family. | Speckle-type POZ protein; Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. In complex with CUL3, involved in ubiquitination and proteasomal degradation of BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. In complex with CUL3, involved in ubiquitination of MACROH2A1 and BMI1; this does not lead to their proteasomal degradation. Inhibits transcriptional activation of PDX1/IPF1 targets, such as insulin, by promoting PDX1/IPF1 degradation. The cullin-RING- [...] | 0.998 |
| CUL3 | SPOPL | ENSPPYP00000014786 | ENSPPYP00000014314 | CUL3 isoform 1; Belongs to the cullin family. | Speckle type BTB/POZ protein like. | 0.992 |
| CUL3 | SUFU | ENSPPYP00000014786 | ENSPPYP00000003030 | CUL3 isoform 1; Belongs to the cullin family. | Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] | 0.953 |
| GLI1 | CUL3 | ENSPPYP00000005342 | ENSPPYP00000014786 | GLI family zinc finger 1. | CUL3 isoform 1; Belongs to the cullin family. | 0.956 |
| GLI1 | GLI2 | ENSPPYP00000005342 | ENSPPYP00000014260 | GLI family zinc finger 1. | GLI2 isoform 1. | 0.991 |
| GLI1 | GLI3 | ENSPPYP00000005342 | ENSPPYP00000019741 | GLI family zinc finger 1. | GLI3 isoform 3. | 0.987 |
| GLI1 | RBX1 | ENSPPYP00000005342 | ENSPPYP00000013235 | GLI family zinc finger 1. | RBX1 isoform 1. | 0.432 |
| GLI1 | SPOP | ENSPPYP00000005342 | ENSPPYP00000010012 | GLI family zinc finger 1. | Speckle-type POZ protein; Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. In complex with CUL3, involved in ubiquitination and proteasomal degradation of BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. In complex with CUL3, involved in ubiquitination of MACROH2A1 and BMI1; this does not lead to their proteasomal degradation. Inhibits transcriptional activation of PDX1/IPF1 targets, such as insulin, by promoting PDX1/IPF1 degradation. The cullin-RING- [...] | 0.968 |
| GLI1 | SPOPL | ENSPPYP00000005342 | ENSPPYP00000014314 | GLI family zinc finger 1. | Speckle type BTB/POZ protein like. | 0.967 |
| GLI1 | SUFU | ENSPPYP00000005342 | ENSPPYP00000003030 | GLI family zinc finger 1. | Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] | 0.999 |
| GLI2 | CUL3 | ENSPPYP00000014260 | ENSPPYP00000014786 | GLI2 isoform 1. | CUL3 isoform 1; Belongs to the cullin family. | 0.968 |
| GLI2 | GLI1 | ENSPPYP00000014260 | ENSPPYP00000005342 | GLI2 isoform 1. | GLI family zinc finger 1. | 0.991 |
| GLI2 | GLI3 | ENSPPYP00000014260 | ENSPPYP00000019741 | GLI2 isoform 1. | GLI3 isoform 3. | 0.984 |
| GLI2 | RBX1 | ENSPPYP00000014260 | ENSPPYP00000013235 | GLI2 isoform 1. | RBX1 isoform 1. | 0.630 |
| GLI2 | SPOP | ENSPPYP00000014260 | ENSPPYP00000010012 | GLI2 isoform 1. | Speckle-type POZ protein; Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. In complex with CUL3, involved in ubiquitination and proteasomal degradation of BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. In complex with CUL3, involved in ubiquitination of MACROH2A1 and BMI1; this does not lead to their proteasomal degradation. Inhibits transcriptional activation of PDX1/IPF1 targets, such as insulin, by promoting PDX1/IPF1 degradation. The cullin-RING- [...] | 0.990 |
| GLI2 | SPOPL | ENSPPYP00000014260 | ENSPPYP00000014314 | GLI2 isoform 1. | Speckle type BTB/POZ protein like. | 0.983 |
