STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PKP4PKP4 isoform 2. (1192 aa)    
Predicted Functional Partners:
ERBIN
Erbb2 interacting protein.
    
 
 0.874
CTNNB1
CTNNB1 isoform 2.
   
 0.794
DSP
DSP isoform 1.
    
 0.783
CDH17
CDH17 isoform 1.
    
 0.719
CDH5
CDH5 isoform 2; Cadherins are calcium-dependent cell adhesion proteins.
    
 0.701
CTNNA3
CTNNA3 isoform 1.
   
 0.686
JUP
JUP isoform 1.
   
 0.682
CTNNA2
Catenin alpha-2; May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system. Required for proper regulation of cortical neuronal migration and neurite growth. It acts as negative regulator of Arp2/3 complex activity and Arp2/3-mediated actin polymerization. It thereby suppresses excessive actin branching which would impair neurite growth and stability. Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of star [...]
   
 0.680
CTNNA1
CTNNA1 isoform 1.
   
 0.680
ECT2
ECT2 isoform 4.
    
 
 0.654
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.