STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ITGB6Integrin beta; Belongs to the integrin beta chain family. (714 aa)    
Predicted Functional Partners:
ITGAV
ITGAV isoform 2; Belongs to the integrin alpha chain family.
   
 0.997
TGFB1
Transforming growth factor beta; Belongs to the TGF-beta family.
   
 0.972
TNC
TNC isoform 1.
   
0.953
PTK2
PTK2 isoform 11; Belongs to the protein kinase superfamily. Tyr protein kinase family.
   
 0.948
TNN
TNN isoform 1.
   
0.943
SRC
Tyrosine-protein kinase.
   
 0.936
FN1
FN1 isoform 4.
   
 
 0.933
ACTB
Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.
   
 0.922
ACTG1
ACTG1 isoform 10.
   
 0.920
TLN1
TLN1 isoform 1.
   
 0.920
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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